5HFF

The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant) in complex with a mutant C-terminal peptide derived from CRIPT (T-2F)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PDZ domain-like	8032563	3000388	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ	e5hffA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Disks large homolog 4	structural constituent of postsynapse structural molecule activity structural constituent of postsynaptic density structural constituent of synapse structural constituent of postsynaptic specialization beta-2 adrenergic receptor binding protein binding binding adrenergic receptor binding signaling receptor binding G protein-coupled receptor binding frizzled binding protein phosphatase binding phosphatase binding structural constituent of postsynapse structural molecule activity structural constituent of postsynaptic density structural constituent of synapse structural constituent of postsynaptic specialization beta-2 adrenergic receptor binding protein binding binding adrenergic receptor binding signaling receptor binding G protein-coupled receptor binding frizzled binding protein phosphatase binding phosphatase binding enzyme binding protein-containing complex binding D1 dopamine receptor binding dopamine receptor binding cytoskeletal protein binding kinesin binding PDZ domain binding protein domain specific binding glutamate receptor binding scaffold protein binding ionotropic glutamate receptor binding kinase binding acetylcholine receptor binding protein kinase binding beta-1 adrenergic receptor binding neuroligin family protein binding P2Y1 nucleotide receptor binding G protein-coupled nucleotide receptor binding	protein localization protein localization to postsynaptic specialization membrane cellular localization protein localization to postsynaptic membrane protein localization to cell periphery protein localization to synapse biological regulation localization within membrane protein localization to membrane protein-containing complex localization neurotransmitter receptor localization to postsynaptic specialization membrane localization regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to organelle cellular macromolecule localization protein localization protein localization to postsynaptic specialization membrane cellular localization protein localization to postsynaptic membrane protein localization to cell periphery protein localization to synapse biological regulation localization within membrane protein localization to membrane protein-containing complex localization neurotransmitter receptor localization to postsynaptic specialization membrane localization regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to organelle cellular macromolecule localization macromolecule localization cellular process protein localization to postsynapse regulation of biological quality protein localization to cell junction receptor localization to synapse cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication positive regulation of response to stimulus synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction positive regulation of cellular process trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication excitatory postsynaptic potential regulation of membrane potential positive regulation of signaling positive regulation of AMPA glutamate receptor clustering regulation of localization regulation of postsynaptic membrane organization positive regulation of cellular component organization regulation of cellular component organization regulation of protein localization regulation of AMPA glutamate receptor clustering positive regulation of postsynaptic membrane organization cellular component organization receptor clustering cellular component organization or biogenesis synapse organization regulation of receptor clustering postsynaptic membrane organization regulation of protein localization to membrane membrane organization postsynapse organization positive regulation of receptor clustering AMPA glutamate receptor clustering positive regulation of protein localization to membrane glutamate receptor clustering neurotransmitter-gated ion channel clustering regulation of glutamate receptor clustering cell junction organization regulation of cellular localization positive regulation of protein localization neurotransmitter receptor diffusion trapping receptor diffusion trapping postsynaptic neurotransmitter receptor diffusion trapping cellular response to metal ion cellular response to chemical stimulus response to metal ion response to potassium ion response to chemical cellular response to potassium ion import into cell receptor internalization transport negative regulation of biological process negative regulation of transport negative regulation of endocytosis regulation of receptor internalization vesicle-mediated transport negative regulation of cellular process regulation of endocytosis negative regulation of cellular component organization regulation of transport negative regulation of receptor-mediated endocytosis regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization endocytosis receptor-mediated endocytosis negative regulation of receptor internalization regulation of behavior behavior regulation of grooming behavior grooming behavior regulation of neuronal synaptic plasticity regulation of synaptic plasticity regulation of long-term neuronal synaptic plasticity developmental process head development forebrain development animal organ development brain development nervous system development pallium development cerebral cortex development multicellular organism development central nervous system development anatomical structure development telencephalon development system development dendritic spine organization plasma membrane bounded cell projection organization cell projection organization neuron projection organization cellular developmental process plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation dendritic spine morphogenesis dendritic spine development dendrite morphogenesis cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development ligand-gated ion channel signaling pathway ionotropic glutamate receptor signaling pathway glutamate receptor signaling pathway NMDA selective glutamate receptor signaling pathway regulation of developmental process regulation of neuron projection arborization regulation of cell morphogenesis positive regulation of developmental process positive regulation of cell projection organization regulation of anatomical structure morphogenesis regulation of cell projection organization positive regulation of neuron projection arborization neuron projection arborization positive regulation of synaptic transmission positive regulation of cytosolic calcium ion concentration cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly positive regulation of nervous system development regulation of nervous system development cell junction assembly regulation of synapse structure or activity regulation of synapse assembly regulation of multicellular organismal development positive regulation of cellular component biogenesis regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly regulation of synapse organization positive regulation of multicellular organismal process synapse assembly positive regulation of synapse assembly establishment of protein localization regulation of signaling receptor activity regulation of transmembrane transporter activity regulation of transporter activity regulation of NMDA receptor activity regulation of monoatomic ion transmembrane transporter activity transmembrane transport regulation of molecular function regulation of transmembrane transport regulation of neurotransmitter receptor activity neuromuscular process neuromuscular process controlling balance locomotory behavior exploration behavior locomotory exploration behavior developmental maturation neuronal ion channel clustering anatomical structure maturation neuron maturation cell maturation biological process involved in intraspecies interaction between organisms social behavior cell adhesion cell-cell adhesion vocalization behavior regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of dendrite morphogenesis positive regulation of cell development positive regulation of cell morphogenesis regulation of dendrite development regulation of neuron projection development positive regulation of cell differentiation positive regulation of neurogenesis positive regulation of dendrite morphogenesis regulation of plasma membrane bounded cell projection organization vesicle organization synaptic vesicle maturation organelle organization establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment or maintenance of apical/basal cell polarity establishment or maintenance of cell polarity	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region somatodendritic compartment cell projection dendritic branch dendrite dendritic tree neuron projection plasma membrane bounded cell projection axon main axon juxtaparanode region of axon cell-cell junction anchoring junction protein-containing complex plasma membrane protein complex membrane protein complex transporter complex receptor complex AMPA glutamate receptor complex ionotropic glutamate receptor complex neurotransmitter receptor complex transmembrane transporter complex plasma membrane signaling receptor complex monoatomic ion channel complex proximal dendrite intracellular anatomical structure cytoplasm cytosol basal part of cell basal plasma membrane basolateral plasma membrane glutamatergic synapse neuromuscular junction neuron spine dendritic spine membrane-bounded organelle transport vesicle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle presynapse cytoplasmic vesicle synaptic vesicle secretory vesicle vesicle exocytic vesicle cell cortex cortical cytoskeleton intracellular membraneless organelle cytoskeleton membraneless organelle neuron projection cytoplasm cytoplasmic region plasma membrane bounded cell projection cytoplasm dendrite cytoplasm neuron projection terminus excitatory synapse cerebellar mossy fiber endoplasmic reticulum
B	Cysteine-rich PDZ-binding protein	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding protein-containing complex binding PDZ domain binding protein domain specific binding scaffold protein binding	RNA splicing RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process biosynthetic process metabolic process cellular process RNA processing RNA splicing RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization multicellular organismal process regulation of cellular component organization regulation of cellular process regulation of postsynaptic specialization assembly cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly regulation of excitatory synapse assembly postsynaptic density organization anatomical structure development regulation of synapse structure or activity synapse organization regulation of biological quality regulation of synapse assembly regulation of postsynaptic density organization system development developmental process regulation of biological process postsynapse organization organelle assembly postsynaptic specialization assembly postsynapse assembly biological regulation regulation of postsynapse organization nervous system development regulation of cellular component biogenesis regulation of organelle organization excitatory synapse assembly regulation of cell junction assembly regulation of synapse organization cell junction organization regulation of organelle assembly postsynaptic specialization organization synapse assembly postsynaptic density assembly regulation of postsynaptic density assembly protein localization to microtubule cytoskeleton protein localization protein localization to microtubule localization cellular localization protein localization to cytoskeleton protein localization to organelle cellular macromolecule localization macromolecule localization regulation of localization regulation of protein localization postsynaptic density protein 95 clustering regulation of postsynaptic density protein 95 clustering regulation of protein localization to membrane postsynaptic membrane organization membrane organization localization within membrane protein localization to membrane regulation of cellular localization mRNA processing mRNA metabolic process	somatodendritic compartment cell projection cellular anatomical structure dendrite dendritic tree neuron projection dendritic shaft plasma membrane bounded cell projection neuron spine synapse dendritic spine postsynapse cell junction membrane-bounded organelle somatodendritic compartment cell projection cellular anatomical structure dendrite dendritic tree neuron projection dendritic shaft plasma membrane bounded cell projection neuron spine synapse dendritic spine postsynapse cell junction membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex cell body neuronal cell body postsynaptic density, intracellular component postsynaptic specialization intracellular membraneless organelle postsynaptic specialization, intracellular component postsynaptic density neuron to neuron synapse membraneless organelle asymmetric synapse cytoplasm glutamatergic synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR020590	Guanylate kinase, conserved site	Conserved Site
A	IPR019583	Disks large homolog 1-4, PDZ-associated domain	Domain
A	IPR016313	Disks large 1-like	Family
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR050614	Synaptic Scaffolding LAP/MAGUK Families	Family
A	IPR001452	SH3 domain	Domain
A	IPR019590	Disks large homologue 1, N-terminal PEST domain	Domain
A	IPR008144	Guanylate kinase-like domain	Domain
A	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain
B	IPR019367	PDZ-binding protein, CRIPT	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.