5K18

The NatB Acetyltransferase Complex Bound To bisubstrate inhibitor

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Acetyltransf_10_5	e5k18B1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_5	ECOD (1.6)
D	Acetyltransf_10_5	e5k18D1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_5	ECOD (1.6)
A	NatB_MDM20	e5k18A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: NatB_MDM20	ECOD (1.6)
C	NatB_MDM20	e5k18C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: NatB_MDM20	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D	PF00583	Acetyltransferase (GNAT) family (Acetyltransf_1)	Acetyltransferase (GNAT) family	-	Family
A, C	PF09797	N-acetyltransferase B complex (NatB) non catalytic subunit (NatB_MDM20)	N-acetyltransferase B complex (NatB) non catalytic subunit	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, D	N-terminal acetyltransferase B complex subunit NAT3	acetyltransferase activity N-acetyltransferase activity acyltransferase activity peptide alpha-N-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity peptide N-acetyltransferase activity catalytic activity N-acyltransferase activity	primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation biosynthetic process peptidyl-methionine modification N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation peptidyl-amino acid modification metabolic process cellular process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation biosynthetic process peptidyl-methionine modification N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation peptidyl-amino acid modification metabolic process cellular process N-terminal peptidyl-methionine acetylation protein metabolic process macromolecule metabolic process protein modification process	NatB complex protein-containing complex intracellular anatomical structure catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex cellular anatomical structure protein acetyltransferase complex cytoplasm intracellular protein-containing complex
E [auth F], F [auth E]	Bisubstrate inhibitor	-	-	-
A, C	Uncharacterized protein	-	primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation biosynthetic process peptidyl-methionine modification N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation peptidyl-amino acid modification metabolic process cellular process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation biosynthetic process peptidyl-methionine modification N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation peptidyl-amino acid modification metabolic process cellular process N-terminal peptidyl-methionine acetylation protein metabolic process macromolecule metabolic process protein modification process	NatB complex protein-containing complex intracellular anatomical structure catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex cellular anatomical structure protein acetyltransferase complex cytoplasm intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
B, D	IPR000182	GNAT domain	Domain
B, D	IPR051646	N-terminal NatB acetyltransferase catalytic subunit	Family
A, C	IPR019183	N-alpha-acetyltransferase 25, NatB auxiliary subunit	Family
A, C	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
E [auth F], F [auth E]	ACE	RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 PSI-MOD : N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.