5LXG

Revised crystal structure of the human adiponectin receptor 1 in an open conformation

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth H]	d5lxgh_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	House mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C [auth L]	d5lxgl_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	House mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HlyIII	e5lxgA1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: HlyIII	ECOD (1.6)
B [auth H]	V-set_8	e5lxgH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
C [auth L]	V-set	e5lxgL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth H]	Heavy Chain	IGHV1	-	adiponectin receptor protein 1	SAbDab (2024-12-06)
C [auth L]	Light Chain	IGKV12	Kappa	adiponectin receptor protein 1	SAbDab (2024-12-06)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03006	Haemolysin-III related (HlyIII)	Haemolysin-III related	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Adiponectin receptor protein 1	molecular transducer activity signaling receptor activity protein-hormone receptor activity adipokinetic hormone receptor activity protein binding binding kinase binding enzyme binding protein kinase binding adiponectin binding hormone binding cation binding ion binding metal ion binding molecular transducer activity signaling receptor activity protein-hormone receptor activity adipokinetic hormone receptor activity protein binding binding kinase binding enzyme binding protein kinase binding adiponectin binding hormone binding cation binding ion binding metal ion binding small molecule binding identical protein binding	cellular response to stimulus cell surface receptor signaling pathway via STAT regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of cellular process regulation of receptor signaling pathway via JAK-STAT signal transduction negative regulation of receptor signaling pathway via JAK-STAT cellular response to stimulus cell surface receptor signaling pathway via STAT regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of cellular process regulation of receptor signaling pathway via JAK-STAT signal transduction negative regulation of receptor signaling pathway via JAK-STAT regulation of biological process regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus biological regulation negative regulation of signal transduction regulation of response to stimulus regulation of cell communication cellular process negative regulation of receptor signaling pathway via STAT regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT cellular response to nitrogen compound positive regulation of cell communication positive regulation of signal transduction response to peptide hormone positive regulation of biological process insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway positive regulation of cellular process cellular response to hormone stimulus positive regulation of cellular response to insulin stimulus response to endogenous stimulus regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to insulin cellular response to insulin stimulus positive regulation of signaling adiponectin-activated signaling pathway response to cytokine hormone-mediated signaling pathway cytokine-mediated signaling pathway response to peptide cellular response to cytokine stimulus multicellular organismal process homeostatic process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process metabolic process regulation of multicellular organismal process regulation of metabolic process negative regulation of locomotion regulation of cell motility tissue migration negative regulation of epithelial cell migration ameboidal-type cell migration regulation of cell migration cell migration epithelial cell migration cell motility regulation of epithelial cell migration locomotion negative regulation of cell migration epithelium migration regulation of locomotion negative regulation of cell motility negative regulation of multicellular organismal process regulation of lipid metabolic process primary metabolic process lipid metabolic process regulation of primary metabolic process positive regulation of receptor signaling pathway via STAT positive regulation of receptor signaling pathway via JAK-STAT regulation of epithelial to mesenchymal transition regulation of developmental process cellular developmental process regulation of cell differentiation mesenchyme development cell differentiation anatomical structure development negative regulation of cell differentiation developmental process negative regulation of developmental process animal organ development tissue development negative regulation of epithelial to mesenchymal transition epithelial to mesenchymal transition mesenchymal cell differentiation fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process lipid modification organic acid metabolic process fatty acid oxidation small molecule metabolic process lipid oxidation monocarboxylic acid metabolic process cellular response to leptin stimulus response to leptin leptin-mediated signaling pathway regulation of growth regulation of cellular component organization growth negative regulation of cell growth regulation of cell growth cell growth cellular component organization negative regulation of growth cellular component organization or biogenesis negative regulation of intracellular signal transduction regulation of non-canonical NF-kappaB signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette negative regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process regulation of small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process glucose metabolic process chemical homeostasis glucose homeostasis carbohydrate homeostasis	cellular anatomical structure membrane cell periphery plasma membrane
B [auth H]	V REGION HEAVY CHAIN	-	-	-
C [auth L]	V REGION LIGHT CHAIN	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004254	AdipoR/Haemolysin-III-related	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96A54	female infertility chronic kidney disease atrial fibrillation invasive ductal breast carcinoma Sjogren syndrome Female sterility obesity disorder inborn carbohydrate metabolic disorder plasma cell myeloma type 2 diabetes mellitus

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	AdipoR/Haemolysin-III-related proteins

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Adiponectin Receptors	AdipoR1 adiponectin 1 receptor in complex with an Fv fragment

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.