5QRE

PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z117233350

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2B Superfamily	PLP-dependent transferases	8078139	3000954	SCOP2B (2022-06-29)
A [auth B]	SCOP2B Superfamily	PLP-dependent transferases	8078139	3000954	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	Aminotran_1_2_C_9	e5qreA1	A: a+b two layers	X: C-terminal domain in some PLP-dependent transferases (From Topology)	H: C-terminal domain in some PLP-dependent transferases (From Topology)	T: C-terminal domain in some PLP-dependent transferases	F: Aminotran_1_2_C_9	ECOD (1.6)
B [auth A]	Aminotran_5_N	e5qreA2	A: a/b three-layered sandwiches	X: PLP-dependent transferases (From Topology)	H: PLP-dependent transferases (From Topology)	T: PLP-dependent transferases	F: Aminotran_5_N	ECOD (1.6)
A [auth B]	Aminotran_1_2_C_9	e5qreB1	A: a+b two layers	X: C-terminal domain in some PLP-dependent transferases (From Topology)	H: C-terminal domain in some PLP-dependent transferases (From Topology)	T: C-terminal domain in some PLP-dependent transferases	F: Aminotran_1_2_C_9	ECOD (1.6)
A [auth B]	Aminotran_5_N	e5qreB2	A: a/b three-layered sandwiches	X: PLP-dependent transferases (From Topology)	H: PLP-dependent transferases (From Topology)	T: PLP-dependent transferases	F: Aminotran_5_N	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF00155	Aminotransferase class I and II (Aminotran_1_2)	Aminotransferase class I and II	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	5-aminolevulinate synthase, erythroid-specific, mitochondrial	vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding N-succinyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity succinyltransferase activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding N-succinyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity succinyltransferase activity catalytic activity 5-aminolevulinate synthase activity N-acyltransferase activity	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis hemoglobin biosynthetic process biosynthetic process metabolic process cellular process intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis hemoglobin biosynthetic process biosynthetic process metabolic process cellular process primary metabolic process macromolecule metabolic process protein metabolic process macromolecule biosynthetic process hemoglobin metabolic process developmental process multicellular organismal process erythrocyte development cellular developmental process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process cell differentiation anatomical structure development myeloid cell development homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis response to decreased oxygen levels response to stimulus response to hypoxia response to stress response to oxygen levels response to abiotic stimulus pigment metabolic process heme metabolic process porphyrin-containing compound biosynthetic process tetrapyrrole metabolic process heme biosynthetic process pigment biosynthetic process tetrapyrrole biosynthetic process porphyrin-containing compound metabolic process protoporphyrinogen IX metabolic process protoporphyrinogen IX biosynthetic process intracellular oxygen homeostasis	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR015118	5-aminolevulinate synthase presequence	Domain
A [auth B], B [auth A]	IPR001917	Aminotransferase, class-II, pyridoxal-phosphate binding site	Binding Site
A [auth B], B [auth A]	IPR015421	Pyridoxal phosphate-dependent transferase, major domain	Homologous Superfamily
A [auth B], B [auth A]	IPR015422	Pyridoxal phosphate-dependent transferase, small domain	Homologous Superfamily
A [auth B], B [auth A]	IPR015424	Pyridoxal phosphate-dependent transferase	Homologous Superfamily
A [auth B], B [auth A]	IPR010961	Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase	Domain
A [auth B], B [auth A]	IPR004839	Aminotransferase, class I/classII, large domain	Domain
A [auth B], B [auth A]	IPR050087	8-amino-7-oxononanoate synthase class-II	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth A]	Pharos: P22557	X-linked sideroblastic anemia 1 sideroblastic anemia inherited porphyria Liver Neoplasms, Experimental X-linked erythropoietic protoporphyria androgenetic alopecia breast carcinoma dermatomyositis MALT lymphoma ovarian cancer tuberculosis aplastic anemia congenital anemia erythropoietic protoporphyria medulloblastoma X-linked sideroblastic anemia 1 sideroblastic anemia inherited porphyria Liver Neoplasms, Experimental X-linked erythropoietic protoporphyria androgenetic alopecia breast carcinoma dermatomyositis MALT lymphoma ovarian cancer tuberculosis aplastic anemia congenital anemia erythropoietic protoporphyria medulloblastoma inborn errors of metabolism lung adenocarcinoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.