5V42
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM3
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Hydrolase_4_1 | e5v42A1 | A: a/b three-layered sandwiches | X: alpha/beta-Hydrolases (From Topology) | H: alpha/beta-Hydrolases (From Topology) | T: alpha/beta-Hydrolases | F: Hydrolase_4_1 | ECOD (1.6) |
B | Hydrolase_4_1 | e5v42B1 | A: a/b three-layered sandwiches | X: alpha/beta-Hydrolases (From Topology) | H: alpha/beta-Hydrolases (From Topology) | T: alpha/beta-Hydrolases | F: Hydrolase_4_1 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00975 | Thioesterase domain (Thioesterase) | Thioesterase domain | Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of v ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR016035 | Acyl transferase/acyl hydrolase/lysophospholipase | Homologous Superfamily | |
IPR014031 | Beta-ketoacyl synthase, C-terminal | Domain | |
IPR032821 | Polyketide synthase, C-terminal extension | Domain | |
IPR009081 | Phosphopantetheine binding ACP domain | Domain | |
IPR053778 | Polyketide synthase Pks13 | Family | |
IPR020806 | Polyketide synthase-like, phosphopantetheine-binding domain | Domain | |
IPR029058 | Alpha/Beta hydrolase fold | Homologous Superfamily | |
IPR016039 | Thiolase-like | Homologous Superfamily | |
IPR001227 | Acyl transferase domain superfamily | Homologous Superfamily | |
IPR016036 | Malonyl-CoA ACP transacylase, ACP-binding | Homologous Superfamily | |
IPR050091 | Polyketide and Nonribosomal Peptide Biosynthesis Enzymes | Family | |
IPR018201 | Beta-ketoacyl synthase, active site | Active Site | |
IPR014030 | Beta-ketoacyl synthase-like, N-terminal | Domain | |
IPR020841 | Polyketide synthase, beta-ketoacyl synthase domain | Domain | |
IPR036736 | ACP-like superfamily | Homologous Superfamily | |
IPR014043 | Acyl transferase domain | Domain | |
IPR001031 | Thioesterase | Domain |