6D5H
Ras:SOS:Ras in complex with a small molecule activator
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
- Protein Modification Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C | d6d5hc1 | Alpha and beta proteins (a/b) | P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | G proteins | cH-p21 Ras protein | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
C | d6d5hc2 | Artifacts | Tags | Tags | Tags | N-terminal Tags | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
A | d6d5ha_ | Alpha and beta proteins (a/b) | P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | G proteins | cH-p21 Ras protein | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d6d5hb1 | All alpha proteins | Ras GEF | Ras GEF | Ras GEF | Son of sevenless protein homolog 1 (sos-1) | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d6d5hb2 | Artifacts | Tags | Tags | Tags | N-terminal Tags | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
C | SCOP2B Superfamily | Ras-like P-loop GTPases | 8019405 | 3002022 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Ras-like P-loop GTPases | 8019405 | 3002022 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Ras GEF | 8057967 | 3000128 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | ENTH/VHS domain-like | 8057961 | 3000164 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C | Ras | e6d5hC1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: Ras | ECOD (1.6) |
A | Ras | e6d5hA1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: Ras | ECOD (1.6) |
B | RasGEF | e6d5hB1 | A: alpha superhelices | X: Repetitive alpha hairpins | H: Ras GEF (From Topology) | T: Ras GEF | F: RasGEF | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
C | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (4.3.0) |
A | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (4.3.0) |
B | 1.20.870.10 | Mainly Alpha | Up-down Bundle | Son of sevenless (SoS) protein | Chain S, domain 1 | CATH (4.3.0) |
B | 1.10.840.10 | Mainly Alpha | Orthogonal Bundle | Son of Sevenless (SoS) protein | Chain S, domain 2 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00071 | Ras family (Ras) | Ras family | Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ... | Domain | |
PF00071 | Ras family (Ras) | Ras family | Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ... | Domain | |
PF00617 | RasGEF domain (RasGEF) | RasGEF domain | - | Family | |
PF00618 | RasGEF N-terminal motif (RasGEF_N) | RasGEF N-terminal motif | A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain. | Domain |