6EUY
Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | Flu_PB2_4th | e6euyB1 | A: alpha arrays | X: Helical domain in PB2 (From Topology) | H: Helical domain in PB2 (From Topology) | T: Helical domain in PB2 | F: Flu_PB2_4th | ECOD (1.6) |
B | Flu_PB2_5th | e6euyB2 | A: a+b three layers | X: Polymerase basic protein 2 cap-binding domain (From Topology) | H: Polymerase basic protein 2 cap-binding domain (From Topology) | T: Polymerase basic protein 2 cap-binding domain | F: Flu_PB2_5th | ECOD (1.6) |
A | Flu_PB2_4th | e6euyA2 | A: alpha arrays | X: Helical domain in PB2 (From Topology) | H: Helical domain in PB2 (From Topology) | T: Helical domain in PB2 | F: Flu_PB2_4th | ECOD (1.6) |
A | Flu_PB2_5th | e6euyA1 | A: a+b three layers | X: Polymerase basic protein 2 cap-binding domain (From Topology) | H: Polymerase basic protein 2 cap-binding domain (From Topology) | T: Polymerase basic protein 2 cap-binding domain | F: Flu_PB2_5th | ECOD (1.6) |
C | Flu_PB2_4th | e6euyC1 | A: alpha arrays | X: Helical domain in PB2 (From Topology) | H: Helical domain in PB2 (From Topology) | T: Helical domain in PB2 | F: Flu_PB2_4th | ECOD (1.6) |
C | Flu_PB2_5th | e6euyC2 | A: a+b three layers | X: Polymerase basic protein 2 cap-binding domain (From Topology) | H: Polymerase basic protein 2 cap-binding domain (From Topology) | T: Polymerase basic protein 2 cap-binding domain | F: Flu_PB2_5th | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00604 | Influenza RNA polymerase PB2 CAP binding domain (Flu_PB2_5th) | Influenza RNA polymerase PB2 CAP binding domain | Influenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase ... | Domain |