6IOL | pdb_00006iol

Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
AMR Gene: CARD Annotation
AMR Gene Family: CARD Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth I]	SCOP2B Superfamily	HlyD C-terminal domain-like	8092210	3002572	SCOP2B (2022-06-29)
A [auth I]	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
A [auth I]	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
B [auth J]	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
B [auth J]	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
B [auth J]	SCOP2B Superfamily	HlyD C-terminal domain-like	8092210	3002572	SCOP2B (2022-06-29)
C [auth K]	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
C [auth K]	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
C [auth K]	SCOP2B Superfamily	HlyD C-terminal domain-like	8092210	3002572	SCOP2B (2022-06-29)
D [auth L]	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
D [auth L]	SCOP2B Superfamily	HlyD C-terminal domain-like	8092210	3002572	SCOP2B (2022-06-29)
D [auth L]	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
E [auth M]	SCOP2B Superfamily	HlyD C-terminal domain-like	8092210	3002572	SCOP2B (2022-06-29)
E [auth M]	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
E [auth M]	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
F [auth N]	SCOP2B Superfamily	HlyD beta-barrel domain-like	8041312	3002000	SCOP2B (2022-06-29)
F [auth N]	SCOP2B Superfamily	HlyD C-terminal domain-like	8092210	3002572	SCOP2B (2022-06-29)
F [auth N]	SCOP2B Superfamily	Single hybrid motif	8055550	3001880	SCOP2B (2022-06-29)
G [auth A]	SCOP2B Superfamily	Outer membrane efflux proteins (OEP)	8043654	3000246	SCOP2B (2022-06-29)
H [auth B]	SCOP2B Superfamily	Outer membrane efflux proteins (OEP)	8043654	3000246	SCOP2B (2022-06-29)
I [auth C]	SCOP2B Superfamily	Outer membrane efflux proteins (OEP)	8043654	3000246	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth I]	PRK15030_2nd	e6iolI2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PRK15030_2nd	ECOD (1.6)
A [auth I]	HlyD_D23_C_1	e6iolI1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
A [auth I]	PRK15030_1st	e6iolI4	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
A [auth I]	HlyD_1st	e6iolI3	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
B [auth J]	PRK15030_2nd	e6iolJ3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PRK15030_2nd	ECOD (1.6)
B [auth J]	HlyD_D23_C_1	e6iolJ4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
B [auth J]	PRK15030_1st	e6iolJ1	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
B [auth J]	HlyD_1st	e6iolJ2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
C [auth K]	PRK15030_2nd	e6iolK3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PRK15030_2nd	ECOD (1.6)
C [auth K]	HlyD_D23_C_1	e6iolK4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
C [auth K]	PRK15030_1st	e6iolK1	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
C [auth K]	HlyD_1st	e6iolK2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
D [auth L]	PRK15030_2nd	e6iolL2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PRK15030_2nd	ECOD (1.6)
D [auth L]	HlyD_D23_C_1	e6iolL3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
D [auth L]	PRK15030_1st	e6iolL1	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
D [auth L]	HlyD_1st	e6iolL4	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
E [auth M]	PRK15030_2nd	e6iolM2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PRK15030_2nd	ECOD (1.6)
E [auth M]	HlyD_D23_C_1	e6iolM4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
E [auth M]	PRK15030_1st	e6iolM3	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
E [auth M]	HlyD_1st	e6iolM1	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
F [auth N]	PRK15030_2nd	e6iolN1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PRK15030_2nd	ECOD (1.6)
F [auth N]	HlyD_D23_C_1	e6iolN2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: HlyD_D23_C_1	ECOD (1.6)
F [auth N]	PRK15030_1st	e6iolN3	A: alpha bundles	X: helical hairpin of HlyD-like secretion proteins (From Topology)	H: helical hairpin of HlyD-like secretion proteins (From Topology)	T: helical hairpin of HlyD-like secretion proteins	F: PRK15030_1st	ECOD (1.6)
F [auth N]	HlyD_1st	e6iolN4	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: HlyD_1st	ECOD (1.6)
G [auth A]	OEP	e6iolA1	A: a+b duplicates or obligate multimers	X: Outer membrane efflux proteins (OEP) (From Topology)	H: Outer membrane efflux proteins (OEP) (From Topology)	T: Outer membrane efflux proteins (OEP)	F: OEP	ECOD (1.6)
H [auth B]	OEP	e6iolB1	A: a+b duplicates or obligate multimers	X: Outer membrane efflux proteins (OEP) (From Topology)	H: Outer membrane efflux proteins (OEP) (From Topology)	T: Outer membrane efflux proteins (OEP)	F: OEP	ECOD (1.6)
I [auth C]	OEP	e6iolC1	A: a+b duplicates or obligate multimers	X: Outer membrane efflux proteins (OEP) (From Topology)	H: Outer membrane efflux proteins (OEP) (From Topology)	T: Outer membrane efflux proteins (OEP)	F: OEP	ECOD (1.6)
J [auth F]	ACR_tran_4th	e6iolF5	A: alpha bundles	X: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	T: Multidrug efflux transporter AcrB transmembrane domain	F: ACR_tran_4th	ECOD (1.6)
J [auth F]	ACR_tran_1st	e6iolF4	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: ACR_tran_1st	ECOD (1.6)
J [auth F]	ACR_tran_5th	e6iolF7	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: ACR_tran_5th	ECOD (1.6)
J [auth F]	ACR_tran_3rd	e6iolF2	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: ACR_tran_3rd	ECOD (1.6)
J [auth F]	ACR_tran_6th	e6iolF3	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: ACR_tran_6th	ECOD (1.6)
J [auth F]	ACR_tran_2nd	e6iolF8	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB TolC docking domain	F: ACR_tran_2nd	ECOD (1.6)
J [auth F]	ACR_tran_6th_1	e6iolF1	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB TolC docking domain	F: ACR_tran_6th_1	ECOD (1.6)
K [auth G]	ACR_tran_4th	e6iolG7	A: alpha bundles	X: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	T: Multidrug efflux transporter AcrB transmembrane domain	F: ACR_tran_4th	ECOD (1.6)
K [auth G]	ACR_tran_1st	e6iolG6	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: ACR_tran_1st	ECOD (1.6)
K [auth G]	ACR_tran_5th	e6iolG4	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: ACR_tran_5th	ECOD (1.6)
K [auth G]	ACR_tran_3rd	e6iolG5	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: ACR_tran_3rd	ECOD (1.6)
K [auth G]	ACR_tran_6th	e6iolG1	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: ACR_tran_6th	ECOD (1.6)
K [auth G]	ACR_tran_2nd	e6iolG8	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB TolC docking domain	F: ACR_tran_2nd	ECOD (1.6)
K [auth G]	ACR_tran_6th_1	e6iolG2	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB TolC docking domain	F: ACR_tran_6th_1	ECOD (1.6)
L [auth E]	ACR_tran_4th	e6iolE7	A: alpha bundles	X: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	T: Multidrug efflux transporter AcrB transmembrane domain	F: ACR_tran_4th	ECOD (1.6)
L [auth E]	ACR_tran_1st	e6iolE6	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: ACR_tran_1st	ECOD (1.6)
L [auth E]	ACR_tran_5th	e6iolE5	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: ACR_tran_5th	ECOD (1.6)
L [auth E]	ACR_tran_3rd	e6iolE3	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: ACR_tran_3rd	ECOD (1.6)
L [auth E]	ACR_tran_6th	e6iolE4	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: ACR_tran_6th	ECOD (1.6)
L [auth E]	ACR_tran_2nd	e6iolE1	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB TolC docking domain	F: ACR_tran_2nd	ECOD (1.6)
L [auth E]	ACR_tran_6th_1	e6iolE2	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB TolC docking domain	F: ACR_tran_6th_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth J]	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (utative)
C [auth K]	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (utative)
E [auth M]	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (utative)
G [auth A]	1.20.1600.10	Mainly Alpha	Up-down Bundle	Outer membrane efflux proteins (OEP)	Outer membrane efflux proteins (OEP)	CATH (utative)
G [auth A]	2.20.200.10	Mainly Beta	Single Sheet	Outer membrane efflux proteins (OEP)	Outer membrane efflux proteins (OEP)	CATH (utative)
H [auth B]	1.20.1600.10	Mainly Alpha	Up-down Bundle	Outer membrane efflux proteins (OEP)	Outer membrane efflux proteins (OEP)	CATH (utative)
H [auth B]	2.20.200.10	Mainly Beta	Single Sheet	Outer membrane efflux proteins (OEP)	Outer membrane efflux proteins (OEP)	CATH (utative)
I [auth C]	1.20.1600.10	Mainly Alpha	Up-down Bundle	Outer membrane efflux proteins (OEP)	Outer membrane efflux proteins (OEP)	CATH (utative)
I [auth C]	2.20.200.10	Mainly Beta	Single Sheet	Outer membrane efflux proteins (OEP)	Outer membrane efflux proteins (OEP)	CATH (utative)
J [auth F]	3.30.2090.10	Alpha Beta	2-Layer Sandwich	Multidrug efflux transporter AcrB TolC docking domain	DN and DC subdomains	CATH (utative)
K [auth G]	3.30.2090.10	Alpha Beta	2-Layer Sandwich	Multidrug efflux transporter AcrB TolC docking domain	DN and DC subdomains	CATH (utative)
L [auth E]	3.30.2090.10	Alpha Beta	2-Layer Sandwich	Multidrug efflux transporter AcrB TolC docking domain	DN and DC subdomains	CATH (utative)

AMR Gene: CARD Annotation CARD Database Homepage

Chains	Accession	Short Name	Description	Provenance Source (Version)
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N]	ARO:3000377	MexA	MexA is the membrane fusion protein of the MexAB-OprM multidrug efflux complex.	CARD (4.0.0)
G [auth A], H [auth B], I [auth C]	ARO:3000379	OprM	OprM is an outer membrane factor protein found in Pseudomonas aeruginosa and Burkholderia vietnamiensis. It is part of the MexAB-OprM, MexVW-OprM, MexXY-OprM and the AmrAB-OprM complex.	CARD (4.0.0)
J [auth F], K [auth G], L [auth E]	ARO:3000378	MexB	MexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM.	CARD (4.0.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

Chains	Accession	Gene Family	Drug Class	Resistance Machanism	Provenance Source (Version)
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N]	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic, fluoroquinolone antibiotic, monobactam, carbapenem, cephalosporin, penicillin beta-lactam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, phenicol antibiotic	antibiotic efflux	CARD (4.0.0)
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N]	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic, fluoroquinolone antibiotic, monobactam, carbapenem, cephalosporin, penicillin beta-lactam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, phenicol antibiotic	antibiotic efflux	CARD (4.0.0)
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N]	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic, fluoroquinolone antibiotic, monobactam, carbapenem, cephalosporin, penicillin beta-lactam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, phenicol antibiotic	antibiotic efflux	CARD (4.0.0)
G [auth A], H [auth B], I [auth C]	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic, fluoroquinolone antibiotic, monobactam, aminoglycoside antibiotic, carbapenem, cephalosporin, penicillin beta-lactam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, phenicol antibiotic, disinfecting agents and antiseptics	antibiotic efflux	CARD (4.0.0)
G [auth A], H [auth B], I [auth C]	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic, fluoroquinolone antibiotic, monobactam, aminoglycoside antibiotic, carbapenem, cephalosporin, penicillin beta-lactam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, phenicol antibiotic, disinfecting agents and antiseptics	antibiotic efflux	CARD (4.0.0)
G [auth A], H [auth B], I [auth C]	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic, fluoroquinolone antibiotic, monobactam, aminoglycoside antibiotic, carbapenem, cephalosporin, penicillin beta-lactam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, phenicol antibiotic, disinfecting agents and antiseptics	antibiotic efflux	CARD (4.0.0)
J [auth F], K [auth G], L [auth E]	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic, fluoroquinolone antibiotic, monobactam, carbapenem, cephalosporin, penicillin beta-lactam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, phenicol antibiotic	antibiotic efflux	CARD (4.0.0)
J [auth F], K [auth G], L [auth E]	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic, fluoroquinolone antibiotic, monobactam, carbapenem, cephalosporin, penicillin beta-lactam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, phenicol antibiotic	antibiotic efflux	CARD (4.0.0)
J [auth F], K [auth G], L [auth E]	ARO:0010004	resistance-nodulation-cell division (RND) antibiotic efflux pump	macrolide antibiotic, fluoroquinolone antibiotic, monobactam, carbapenem, cephalosporin, penicillin beta-lactam, tetracycline antibiotic, peptide antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, sulfonamide antibiotic, phenicol antibiotic	antibiotic efflux	CARD (4.0.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N]	PF00529	Cation efflux system protein CusB domain 1 (CusB_dom_1)	Cation efflux system protein CusB domain 1	-	Family
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N]	PF16576	Barrel-sandwich domain of CusB or HlyD membrane-fusion (HlyD_D23)	Barrel-sandwich domain of CusB or HlyD membrane-fusion	This entry represents a domain comprising the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD. It is formed by a barrel-sandwich domain which is inserted in a RIFT-like domain. The barrel-sandwich domain, itself, contains an in ...	This entry represents a domain comprising the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD. It is formed by a barrel-sandwich domain which is inserted in a RIFT-like domain. The barrel-sandwich domain, itself, contains an insert of a three-helical bundle subdomain. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.	Domain
G [auth A], H [auth B], I [auth C]	PF02321	Outer membrane efflux protein (OEP)	Outer membrane efflux protein	-	Family
J [auth F], K [auth G], L [auth E]	PF00873	AcrB/AcrD/AcrF family (ACR_tran)	AcrB/AcrD/AcrF family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N]	Multidrug resistance protein MexA	efflux transmembrane transporter activity transporter activity transmembrane transporter activity identical protein binding protein binding binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis transmembrane transport localization transport establishment of localization response to stimulus cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis transmembrane transport localization transport establishment of localization response to stimulus response to chemical response to antibiotic	cell periphery cellular anatomical structure plasma membrane membrane
G [auth A], H [auth B], I [auth C]	Outer membrane protein OprM	efflux transmembrane transporter activity transporter activity transmembrane transporter activity	transmembrane transport localization transport cellular process establishment of localization response to stimulus response to chemical response to antibiotic	cellular anatomical structure membrane cell periphery cell outer membrane external encapsulating structure cell envelope outer membrane
J [auth F], K [auth G], L [auth E]	Multidrug resistance protein MexB	efflux transmembrane transporter activity transporter activity transmembrane transporter activity xenobiotic transmembrane transporter activity	transmembrane transport localization transport cellular process establishment of localization response to stimulus response to chemical response to antibiotic	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N]	IPR051160	Membrane Fusion Protein (MFP) Efflux	Family
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N]	IPR006143	RND efflux pump, membrane fusion protein	Family
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N]	IPR032317	RND efflux pump, membrane fusion protein, barrel-sandwich domain	Domain
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N]	IPR043602	Cation efflux system protein CusB-like, domain 1	Domain
G [auth A], H [auth B], I [auth C]	IPR003423	Outer membrane efflux protein	Family
G [auth A], H [auth B], I [auth C]	IPR050737	Outer Membrane Factor (OMF)	Family
G [auth A], H [auth B], I [auth C]	IPR010131	RND efflux system, outer membrane lipoprotein, NodT	Family
J [auth F], K [auth G], L [auth E]	IPR001036	Acriflavin resistance protein	Family
J [auth F], K [auth G], L [auth E]	IPR004764	Multidrug resistance protein MdtF-like	Family
J [auth F], K [auth G], L [auth E]	IPR027463	Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains	Homologous Superfamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M] A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N], G [auth A], H [auth B], I [auth C], J [auth F], K [auth G], L [auth E]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth I], B [auth J], C [auth K], D [auth L], E [auth M] A [auth I], B [auth J], C [auth K], D [auth L], E [auth M], F [auth N], G [auth A], H [auth B], I [auth C], J [auth F], K [auth G], L [auth E]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Multi-Drug Efflux Transporters	MexAB-OprM tripartite efflux pump, 0 degree state