6J02 | pdb_00006j02

Crystal structure of the SRCR domain of mouse SCARA1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6j02a_	Alpha and beta proteins (a+b)	SRCR-like	SRCR-like	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d6j02b_	Alpha and beta proteins (a+b)	SRCR-like	SRCR-like	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Scavenger receptor cysteine-rich (SRCR) domain	8095390	4002525	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SRCR-like	8095391	3001377	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	SRCR-like	8095391	3001377	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SRCR	e6j02A1	A: a+b complex topology	X: SRCR-like	H: SRCR-like (From Topology)	T: SRCR-like	F: SRCR	ECOD (1.6)
B	SRCR	e6j02B1	A: a+b complex topology	X: SRCR-like	H: SRCR-like (From Topology)	T: SRCR-like	F: SRCR	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.250.10	Alpha Beta	Roll	Mac-2 Binding Protein	SRCR-like domain	CATH (utative)
B	3.10.250.10	Alpha Beta	Roll	Mac-2 Binding Protein	SRCR-like domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00530	Scavenger receptor cysteine-rich domain (SRCR)	Scavenger receptor cysteine-rich domain	These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Macrophage scavenger receptor types I and II	amide binding amyloid-beta binding binding peptide binding lipoprotein particle binding protein-containing complex binding protein-lipid complex binding low-density lipoprotein particle binding cargo receptor activity scavenger receptor activity	protein localization establishment of protein localization cellular localization nitrogen compound transport transport lipoprotein transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process lipoprotein localization cholesterol storage protein localization establishment of protein localization cellular localization nitrogen compound transport transport lipoprotein transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process lipoprotein localization cholesterol storage regulation of localization regulation of biological process regulation of cellular process lipid storage biological regulation positive regulation of biological process lipid localization positive regulation of lipid localization regulation of lipid storage regulation of lipid localization positive regulation of cholesterol storage nutrient storage regulation of cholesterol storage positive regulation of lipid storage positive regulation of cellular process membrane organization import into cell vesicle-mediated transport cellular component organization phagocytosis, engulfment membrane invagination phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination multicellular organismal process amyloid-beta clearance cholesterol transport lipid transport sterol transport organic hydroxy compound transport regulation of biosynthetic process negative regulation of metabolic process negative regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of cellular process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process negative regulation of macromolecule metabolic process plasma lipoprotein particle clearance regulation of plasma lipoprotein particle levels developmental process regulation of developmental process cellular developmental process macrophage derived foam cell differentiation regulation of cell differentiation positive regulation of developmental process foam cell differentiation positive regulation of cell differentiation cell differentiation regulation of macrophage derived foam cell differentiation positive regulation of macrophage derived foam cell differentiation receptor-mediated endocytosis establishment of localization in cell	protein-containing complex collagen trimer cellular anatomical structure low-density lipoprotein particle extracellular region plasma lipoprotein particle extracellular space lipoprotein particle protein-lipid complex cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR008160	Collagen triple helix repeat	Repeat
A, B	IPR003543	Macrophage scavenger receptor, Class A-I/II	Family
A, B	IPR001190	SRCR domain	Domain
A, B	IPR036772	SRCR-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.