6KS1

Crystal structure of the human adiponectin receptor 2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth H]	d6ks1h_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C [auth L]	d6ks1l_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HlyIII	e6ks1A1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: HlyIII	ECOD (1.6)
B [auth H]	V-set_8	e6ks1H1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
C [auth L]	V-set	e6ks1L1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B [auth H]	-	VH	Mus musculus (house mouse)	IGHV1-1801, IGHJ301	V-DOMAIN VH	IG	FV-HEAVY_KAPPA	IMGT (202448-0)
C [auth L]	-	V-KAPPA	Mus musculus (house mouse)	IGKV12-4102, IGKV12-4101, IGKJ2*01	V-DOMAIN V-KAPPA	IG	FV-HEAVY_KAPPA	IMGT (202448-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth H]	Heavy Chain	IGHV1	-	adiponectin receptor protein 2	SAbDab (2024-12-06)
C [auth L]	Light Chain	IGKV12	Kappa	adiponectin receptor protein 2	SAbDab (2024-12-06)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03006	Haemolysin-III related (HlyIII)	Haemolysin-III related	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Adiponectin receptor protein 2	molecular transducer activity signaling receptor activity protein-hormone receptor activity adipokinetic hormone receptor activity protein binding binding adiponectin binding hormone binding cation binding ion binding metal ion binding small molecule binding identical protein binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling response to endogenous stimulus biological regulation adiponectin-activated signaling pathway response to cytokine hormone-mediated signaling pathway cytokine-mediated signaling pathway cell communication response to peptide cellular response to endogenous stimulus cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling response to endogenous stimulus biological regulation adiponectin-activated signaling pathway response to cytokine hormone-mediated signaling pathway cytokine-mediated signaling pathway cell communication response to peptide cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular response to cytokine stimulus cellular process signal transduction cellular response to hormone stimulus multicellular organismal process homeostatic process positive regulation of biological process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process metabolic process regulation of multicellular organismal process regulation of metabolic process positive regulation of cellular process fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process lipid modification primary metabolic process organic acid metabolic process fatty acid oxidation small molecule metabolic process lipid oxidation monocarboxylic acid metabolic process lipid metabolic process developmental process wound healing blood vessel morphogenesis tube development angiogenesis involved in wound healing angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis vascular wound healing response to stress anatomical structure development anatomical structure formation involved in morphogenesis response to wounding blood vessel development system development chemical homeostasis glucose homeostasis carbohydrate homeostasis	cell periphery cellular anatomical structure plasma membrane membrane
B [auth H]	The heavy chain variable domain (Antibody)	-	-	-
C [auth L]	The light chain variable domain (Antibody)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004254	AdipoR/Haemolysin-III-related	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q86V24	female infertility DOID:0081062 malignant mesothelioma spina bifida Down syndrome obesity disorder ductal breast carcinoma in situ inborn carbohydrate metabolic disorder ovarian cancer type 2 diabetes mellitus

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Adiponectin Receptors	AdipoR1 adiponectin 1 receptor, D208A mutant

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.