6P5X | pdb_00006p5x

Sirohydrochlorin-bound S. typhimurium siroheme synthase


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6p5xa1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Siroheme synthase N-terminal domain-like Siroheme synthase CysG, domain 1 (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)
Ad6p5xa3 Alpha and beta proteins (a/b) Tetrapyrrole methylase Tetrapyrrole methylase Tetrapyrrole methylase Siroheme synthase CysG, domains 4 and 5 (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)
Ad6p5xa2 Multi-domain proteins (alpha and beta) Siroheme synthase middle domains-like Siroheme synthase middle domains-like Siroheme synthase middle domains-like Siroheme synthase CysG, domains 2 and 3 (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)
Bd6p5xb1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Siroheme synthase N-terminal domain-like Siroheme synthase CysG, domain 1 (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)
Bd6p5xb3 Alpha and beta proteins (a/b) Tetrapyrrole methylase Tetrapyrrole methylase Tetrapyrrole methylase Siroheme synthase CysG, domains 4 and 5 (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)
Bd6p5xb2 Multi-domain proteins (alpha and beta) Siroheme synthase middle domains-like Siroheme synthase middle domains-like Siroheme synthase middle domains-like Siroheme synthase CysG, domains 2 and 3 (Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyTetrapyrrole methylase 8001041 3000017 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyCysG/Met8-like 8057834 3000045 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCysG/Met8-like 8057834 3000045 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyTetrapyrrole methylase 8001041 3000017 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ACysG_dimerisere6p5xA3 A: alpha superhelicesX: alpha-helical domain in siroheme synthase middle domains-like (From Topology)H: alpha-helical domain in siroheme synthase middle domains-like (From Topology)T: alpha-helical domain in siroheme synthase middle domains-likeF: CysG_dimeriserECOD (1.6)
ATP_methylase_Ce6p5xA2 A: a+b two layersX: Tetrapyrrole methylase C-terminal domain-likeH: Tetrapyrrole methylase C-terminal domain (From Topology)T: Tetrapyrrole methylase C-terminal domainF: TP_methylase_CECOD (1.6)
ASirohm_synth_Me6p5xA5 A: a+b duplicates or obligate multimersX: SSH domain in siroheme synthase middle domains-like (From Topology)H: SSH domain in siroheme synthase middle domains-like (From Topology)T: SSH domain in siroheme synthase middle domains-likeF: Sirohm_synth_MECOD (1.6)
ANAD_binding_7e6p5xA1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: NAD_binding_7ECOD (1.6)
ATP_methylase_Ne6p5xA4 A: a/b three-layered sandwichesX: Tetrapyrrole methylase N-terminal domain (From Topology)H: Tetrapyrrole methylase N-terminal domain (From Topology)T: Tetrapyrrole methylase N-terminal domainF: TP_methylase_NECOD (1.6)
BCysG_dimerisere6p5xB3 A: alpha superhelicesX: alpha-helical domain in siroheme synthase middle domains-like (From Topology)H: alpha-helical domain in siroheme synthase middle domains-like (From Topology)T: alpha-helical domain in siroheme synthase middle domains-likeF: CysG_dimeriserECOD (1.6)
BTP_methylase_Ce6p5xB4 A: a+b two layersX: Tetrapyrrole methylase C-terminal domain-likeH: Tetrapyrrole methylase C-terminal domain (From Topology)T: Tetrapyrrole methylase C-terminal domainF: TP_methylase_CECOD (1.6)
BSirohm_synth_Me6p5xB5 A: a+b duplicates or obligate multimersX: SSH domain in siroheme synthase middle domains-like (From Topology)H: SSH domain in siroheme synthase middle domains-like (From Topology)T: SSH domain in siroheme synthase middle domains-likeF: Sirohm_synth_MECOD (1.6)
BNAD_binding_7e6p5xB2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: NAD_binding_7ECOD (1.6)
BTP_methylase_Ne6p5xB1 A: a/b three-layered sandwichesX: Tetrapyrrole methylase N-terminal domain (From Topology)H: Tetrapyrrole methylase N-terminal domain (From Topology)T: Tetrapyrrole methylase N-terminal domainF: TP_methylase_NECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF14824Sirohaem biosynthesis protein central (Sirohm_synth_M)Sirohaem biosynthesis protein centralThis is the central domain of a multifunctional enzyme which catalyses the biosynthesis of sirohaem. Both of the catalytic activities of this enzyme (precorrin-2 dehydrogenase EC:1.3.1.76) and sirohydrochlorin ferrochelatase (EC:4.99.1.4) are located ...Domain
A, B
PF00590Tetrapyrrole (Corrin/Porphyrin) Methylases (TP_methylase)Tetrapyrrole (Corrin/Porphyrin) MethylasesThis family uses S-AdoMet in the methylation of diverse substrates. This family includes a related group of bacterial proteins of unknown function, including Swiss:P45528. This family includes the methylase Dipthine synthase. Domain
A, B
PF13241Putative NAD(P)-binding (NAD_binding_7)Putative NAD(P)-bindingThis domain is found in fungi, plants, archaea and bacteria. Domain
A, B
PF10414Sirohaem synthase dimerisation region (CysG_dimeriser)Sirohaem synthase dimerisation regionBacterial sulfur metabolism depends on the iron-containing porphinoid sirohaem. CysG, S-adenosyl-L-methionine (SAM)-dependent bis-methyltransferase, dehydrogenase and ferrochelatase, synthesises sirohaem from uroporphyrinogen III via reactions which ...Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Siroheme synthase -