6QN4

Death-associated Protein Kinase 1 (DAPK1) catalytic and auto-regulatory domains with S289E and S308E mutations

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e6qn4A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (utative)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Death-associated protein kinase 1	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity calcium/calmodulin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups syntaxin-1 binding protein binding binding SNARE binding syntaxin binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity calcium/calmodulin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups syntaxin-1 binding protein binding binding SNARE binding syntaxin binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine kinase activity adenyl ribonucleotide binding adenyl nucleotide binding ATP binding calmodulin binding histone H2AS1 kinase activity histone modifying activity histone H2A kinase activity histone kinase activity identical protein binding	response to tumor cell response to stimulus defense response response to stress defense response to tumor cell response to biotic stimulus regulation of cellular process negative regulation of biological process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process response to tumor cell response to stimulus defense response response to stress defense response to tumor cell response to biotic stimulus regulation of cellular process negative regulation of biological process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process cellular response to stimulus cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound response to oxidative stress cellular response to chemical stimulus cellular response to stress response to chemical response to hydroperoxide cellular response to hydroperoxide negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death regulation of localization signaling transport regulation of signaling receptor activity regulation of transmembrane transporter activity regulation of signal transduction cell communication regulation of transporter activity localization signal transduction regulation of NMDA receptor activity regulation of monoatomic ion transmembrane transporter activity regulation of signaling regulation of transport establishment of localization transmembrane transport regulation of molecular function regulation of transmembrane transport regulation of response to stimulus regulation of neurotransmitter receptor activity regulation of cell communication positive regulation of programmed cell death positive regulation of biological process positive regulation of apoptotic process positive regulation of cellular process extrinsic apoptotic signaling pathway via death domain receptors cell surface receptor signaling pathway extrinsic apoptotic signaling pathway apoptotic signaling pathway protein phosphorylation protein autophosphorylation phosphorylation macromolecule modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process biological process involved in interspecies interaction between organisms immune response response to other organism response to type II interferon response to cytokine defense response to symbiont response to external stimulus cellular response to type II interferon response to peptide immune system process defense response to other organism innate immune response cellular response to cytokine stimulus response to external biotic stimulus autophagic cell death regulation of autophagic cell death positive regulation of autophagic cell death regulation of response to biotic stimulus regulation of response to tumor cell catabolic process autophagy regulation of catabolic process regulation of autophagy process utilizing autophagic mechanism intracellular signal transduction positive regulation of autophagy positive regulation of catabolic process positive regulation of metabolic process	protein kinase complex transferase complex, transferring phosphorus-containing groups DAPK1-calmodulin complex protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle protein kinase complex transferase complex, transferring phosphorus-containing groups DAPK1-calmodulin complex protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cell periphery plasma membrane membrane cytoplasm synapse cell junction glutamatergic synapse postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A	IPR000719	Protein kinase domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR002110	Ankyrin repeat	Repeat
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR000488	Death domain	Domain
A	IPR020676	Death-associated protein kinase 1, catalytic domain	Domain
A	IPR020859	Roc domain	Domain
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P53355	acute myeloid leukemia non-small cell lung carcinoma renal cell carcinoma myelodysplastic syndrome transitional cell carcinoma peripheral nervous system disease juvenile idiopathic arthritis adenocarcinoma adenoid cystic carcinoma peripheral neuropathy salivary gland adenoid cystic carcinoma sarcomatoid renal cell carcinoma Neoplasms, Second Primary papillary renal cell carcinoma granular cell carcinoma acute myeloid leukemia non-small cell lung carcinoma renal cell carcinoma myelodysplastic syndrome transitional cell carcinoma peripheral nervous system disease juvenile idiopathic arthritis adenocarcinoma adenoid cystic carcinoma peripheral neuropathy salivary gland adenoid cystic carcinoma sarcomatoid renal cell carcinoma Neoplasms, Second Primary papillary renal cell carcinoma granular cell carcinoma tubular adenocarcinoma chromophobe renal cell carcinoma collecting duct carcinoma cystic fibrosis primary myelofibrosis renal carcinoma large cell medulloblastoma medulloblastoma atypical teratoid rhabdoid tumor chronic obstructive pulmonary disease pancreatic intraductal papillary-mucinous neoplasm cribriform carcinoma glioblastoma psoriasis invasive ductal breast carcinoma lung benign neoplasm malignant ependymoma tuberculosis adrenoleukodystrophy oligodendroglioma clear cell renal carcinoma conjunctival disorder pilocytic astrocytoma cribriform carcinoma of breast respiratory system disease lung cancer salivary gland cancer malignant glioma astrocytic tumor brain cancer ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.