Annotations: 6RV6

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TSP_1	e6rv6A2	A: few secondary structure elements	X: TSP-1 type 1 repeat (From Topology)	H: TSP-1 type 1 repeat (From Topology)	T: TSP-1 type 1 repeat	F: TSP_1	ECOD (1.6)
A	EUF08747	e6rv6A3	A: few secondary structure elements	X: TSP-1 type 1 repeat (From Topology)	H: TSP-1 type 1 repeat (From Topology)	T: TSP-1 type 1 repeat	F: EUF08747	ECOD (1.6)
B	TSP1	e6rv6B2	A: few secondary structure elements	X: TSP-1 type 1 repeat (From Topology)	H: TSP-1 type 1 repeat (From Topology)	T: TSP-1 type 1 repeat	F: TSP1	ECOD (1.6)
B	TSP_1	e6rv6B1	A: few secondary structure elements	X: TSP-1 type 1 repeat (From Topology)	H: TSP-1 type 1 repeat (From Topology)	T: TSP-1 type 1 repeat	F: TSP_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00090	Thrombospondin type 1 domain (TSP_1)	Thrombospondin type 1 domain	-	Domain
A	PF18487	Thrombospondin type 1 repeat (TSR)	Thrombospondin type 1 repeat	-	Repeat
B	PF00090	Thrombospondin type 1 domain (TSP_1)	Thrombospondin type 1 domain	-	Domain
B	PF22195	CFP-like, C-terminal thrombospondin type 1 domain (TSP1_CFP_C)	CFP-like, C-terminal thrombospondin type 1 domain	This domain is found at the C-terminal end of human Properdin (CFP, for Complement factor P) and similar animal proteins. CFP is a positive regulator of the alternate pathway (AP) of complement. It contains six thrombospondin repeat type I (TSP 1-6 d ...	This domain is found at the C-terminal end of human Properdin (CFP, for Complement factor P) and similar animal proteins. CFP is a positive regulator of the alternate pathway (AP) of complement. It contains six thrombospondin repeat type I (TSP 1-6 domains and an N-terminal domain (Pfam:PF18487). This entry represents the last TSP type I domain, which binds to the first TSP type I domain (Pfam:PF00090), contributing to multimerisation [1-5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Properdin	-	regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process regulation of immune effector process import into cell regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process regulation of immune effector process import into cell regulation of localization regulation of cellular process positive regulation of cellular component organization regulation of cellular component organization transport vesicle-mediated transport cellular component organization opsonization localization positive regulation of endocytosis positive regulation of immune effector process phagocytosis cell recognition cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of opsonization regulation of opsonization immune effector process phagocytosis, recognition positive regulation of phagocytosis positive regulation of transport cellular process endocytosis humoral immune response biological process involved in interspecies interaction between organisms complement activation, alternative pathway response to biotic stimulus complement activation response to stress innate immune response response to external biotic stimulus response to other organism defense response defense response to symbiont response to external stimulus defense response to other organism activation of immune response defense response to bacterium response to bacterium	membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle cellular anatomical structure organelle lumen cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle cellular anatomical structure organelle lumen cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle endoplasmic reticulum lumen endoplasmic reticulum extracellular region Golgi membrane Golgi apparatus cytoplasmic side of membrane membrane cytoplasmic side of Golgi membrane side of membrane bounding membrane of organelle organelle membrane vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule extracellular space
B	Properdin	-	regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process regulation of immune effector process import into cell regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process regulation of immune effector process import into cell regulation of localization regulation of cellular process positive regulation of cellular component organization regulation of cellular component organization transport vesicle-mediated transport cellular component organization opsonization localization positive regulation of endocytosis positive regulation of immune effector process phagocytosis cell recognition cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of opsonization regulation of opsonization immune effector process phagocytosis, recognition positive regulation of phagocytosis positive regulation of transport cellular process endocytosis humoral immune response biological process involved in interspecies interaction between organisms complement activation, alternative pathway response to biotic stimulus complement activation response to stress innate immune response response to external biotic stimulus response to other organism defense response defense response to symbiont response to external stimulus defense response to other organism activation of immune response defense response to bacterium response to bacterium	membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle cellular anatomical structure organelle lumen cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle cellular anatomical structure organelle lumen cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle endoplasmic reticulum lumen endoplasmic reticulum extracellular region Golgi membrane Golgi apparatus cytoplasmic side of membrane membrane cytoplasmic side of Golgi membrane side of membrane bounding membrane of organelle organelle membrane vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
A	IPR052065	Complement and asymmetry regulator	Family
A	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily
A	IPR054019	Properdin, thrombospondin type 1 C-terminal	Repeat
A	IPR049536	Properdin, thrombospondin type 1 repeat 0	Repeat
B	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
B	IPR052065	Complement and asymmetry regulator	Family
B	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily
B	IPR054019	Properdin, thrombospondin type 1 C-terminal	Repeat
B	IPR049536	Properdin, thrombospondin type 1 repeat 0	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P27918	properdin deficiency, X-linked meningococcal meningitis Liver Cirrhosis, Experimental atypical hemolytic-uremic syndrome intellectual disability lung adenocarcinoma MALT lymphoma B-cell chronic lymphocytic leukemia interstitial cystitis lung cancer non-small cell lung carcinoma hepatocellular carcinoma osteosarcoma
B	Pharos: P27918	properdin deficiency, X-linked meningococcal meningitis Liver Cirrhosis, Experimental atypical hemolytic-uremic syndrome intellectual disability lung adenocarcinoma MALT lymphoma B-cell chronic lymphocytic leukemia interstitial cystitis lung cancer non-small cell lung carcinoma hepatocellular carcinoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.