6VQ7 | pdb_00006vq7

Mammalian V-ATPase from rat brain - composite model of rotational state 2 bound to ADP and SidK (built from focused refinement models)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
G	SCOP2B Superfamily	Vacuolar ATP synthase subunit C	8099588	3001744	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ATP-synt_ab_N	e6vq7A2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
A	ATP-synt_ab_C	e6vq7A4	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
A	ATP-synt_ab_Xtn	e6vq7A1	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: ATP-synt_ab_Xtn	ECOD (1.6)
A	ATP-synt_ab	e6vq7A3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
B	ATP-synt_ab_N	e6vq7B3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
B	ATP-synt_ab_C	e6vq7B1	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
B	ATP-synt_ab_Xtn	e6vq7B4	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: ATP-synt_ab_Xtn	ECOD (1.6)
B	ATP-synt_ab	e6vq7B2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
C	ATP-synt_ab_N	e6vq7C2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
C	ATP-synt_ab_C	e6vq7C4	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
C	ATP-synt_ab_Xtn	e6vq7C1	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: ATP-synt_ab_Xtn	ECOD (1.6)
C	ATP-synt_ab	e6vq7C3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
V [auth d]	vATP-synt_AC39_3rd	e6vq7d1	A: alpha bundles	X: V-type ATP synthase subunit C	H: V-type ATP synthase subunit C (From Topology)	T: V-type ATP synthase subunit C	F: vATP-synt_AC39_3rd	ECOD (1.6)
V [auth d]	vATP-synt_AC39_1st	e6vq7d2	A: alpha bundles	X: V-type ATP synthase subunit C	H: V-type ATP synthase subunit C (From Topology)	T: V-type ATP synthase subunit C	F: vATP-synt_AC39_1st	ECOD (1.6)
AA [auth i]	ATP-synt_C	e6vq7i1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
BA [auth j]	ATP-synt_C	e6vq7j2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
CA [auth k]	ATP-synt_C	e6vq7k1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
DA [auth l]	ATP-synt_C	e6vq7l1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
EA [auth m]	ATP-synt_C	e6vq7m1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
FA [auth n]	ATP-synt_C	e6vq7n2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
GA [auth o]	ATP-synt_C	e6vq7o1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
Y [auth g]	ATP-synt_C	e6vq7g2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
Z [auth h]	ATP-synt_C	e6vq7h2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
D	ATP-synt_ab_N	e6vq7D3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
D	ATP-synt_ab_C	e6vq7D1	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
D	ATP-synt_ab	e6vq7D2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
E	ATP-synt_ab_N	e6vq7E1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
E	ATP-synt_ab_C	e6vq7E2	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
E	ATP-synt_ab	e6vq7E3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
F	ATP-synt_ab_N	e6vq7F2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: ATP-synt_ab_N	ECOD (1.6)
F	ATP-synt_ab_C	e6vq7F3	A: alpha superhelices	X: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	H: C-terminal domain of alpha and beta subunits of F1 ATP synthase (From Topology)	T: C-terminal domain of alpha and beta subunits of F1 ATP synthase	F: ATP-synt_ab_C	ECOD (1.6)
F	ATP-synt_ab	e6vq7F1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ATP-synt_ab	ECOD (1.6)
G	V-ATPase_C_1st	e6vq7G1	A: alpha bundles	X: helical bundle domain in vacuolar ATP synthase subunit C (From Topology)	H: helical bundle domain in vacuolar ATP synthase subunit C (From Topology)	T: helical bundle domain in vacuolar ATP synthase subunit C	F: V-ATPase_C_1st	ECOD (1.6)
G	F_UNCLASSIFIED	e6vq7G3	A: a+b two layers	X: Alpha-beta plaits	H: ferredoxin-like domain in vacuolar ATP synthase subunit C (From Topology)	T: ferredoxin-like domain in vacuolar ATP synthase subunit C	F: F_UNCLASSIFIED	ECOD (1.6)
G	V-ATPase_C_2nd	e6vq7G2	A: a+b two layers	X: Alpha-beta plaits	H: ferredoxin-like domain in vacuolar ATP synthase subunit C (From Topology)	T: ferredoxin-like domain in vacuolar ATP synthase subunit C	F: V-ATPase_C_2nd	ECOD (1.6)
H	ATP-synt_D	e6vq7H1	A: alpha bundles	X: V-type proton ATPase subunit D (From Topology)	H: V-type proton ATPase subunit D (From Topology)	T: V-type proton ATPase subunit D	F: ATP-synt_D	ECOD (1.6)
I	vATP-synt_E_C	e6vq7I1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: vATP-synt_E_C	ECOD (1.6)
I	vATP-synt_E_N	e6vq7I2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: vATP-synt_E_N	ECOD (1.6)
J	vATP-synt_E_C	e6vq7J2	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: vATP-synt_E_C	ECOD (1.6)
J	vATP-synt_E_N	e6vq7J1	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: vATP-synt_E_N	ECOD (1.6)
K	vATP-synt_E_C	e6vq7K1	A: a+b two layers	X: FwdE/GAPDH domain-like	H: V-type ATPase subunit E (From Topology)	T: V-type ATPase subunit E	F: vATP-synt_E_C	ECOD (1.6)
K	vATP-synt_E_N	e6vq7K2	A: extended segments	X: Helical region in V-type proton ATPase subunit E (From Topology)	H: Helical region in V-type proton ATPase subunit E (From Topology)	T: Helical region in V-type proton ATPase subunit E	F: vATP-synt_E_N	ECOD (1.6)
L	ATP-synt_F	e6vq7L1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: AtpF-like (From Topology)	T: AtpF-like	F: ATP-synt_F	ECOD (1.6)
M	V-ATPase_G	e6vq7M1	A: extended segments	X: V-type proton ATPase subunit G (From Topology)	H: V-type proton ATPase subunit G (From Topology)	T: V-type proton ATPase subunit G	F: V-ATPase_G	ECOD (1.6)
N	V-ATPase_G	e6vq7N1	A: extended segments	X: V-type proton ATPase subunit G (From Topology)	H: V-type proton ATPase subunit G (From Topology)	T: V-type proton ATPase subunit G	F: V-ATPase_G	ECOD (1.6)
O	V-ATPase_G	e6vq7O1	A: extended segments	X: V-type proton ATPase subunit G (From Topology)	H: V-type proton ATPase subunit G (From Topology)	T: V-type proton ATPase subunit G	F: V-ATPase_G	ECOD (1.6)
P [auth Q]	UNK_F_TYPE	e6vq7Q1	A: alpha superhelices	X: Effector protein SidK (From Topology)	H: Effector protein SidK (From Topology)	T: Effector protein SidK	F: UNK_F_TYPE	ECOD (1.6)
Q [auth R]	UNK_F_TYPE	e6vq7R1	A: alpha superhelices	X: Effector protein SidK (From Topology)	H: Effector protein SidK (From Topology)	T: Effector protein SidK	F: UNK_F_TYPE	ECOD (1.6)
R [auth S]	UNK_F_TYPE	e6vq7S1	A: alpha superhelices	X: Effector protein SidK (From Topology)	H: Effector protein SidK (From Topology)	T: Effector protein SidK	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
A	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (utative)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
B	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (utative)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
C	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (utative)
D	3.40.50.12240	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (utative)
E	3.40.50.12240	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (utative)
F	3.40.50.12240	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (utative)
G	1.20.1460.10	Mainly Alpha	Up-down Bundle	subunit c (vma5p) of the yeast v-atpase, domain 2	subunit c (vma5p) of the yeast v-atpase, domain 2	CATH (utative)
G	3.30.70.100	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (utative)
H	1.10.287.3240	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (utative)
I	3.30.2320.30	Alpha Beta	2-Layer Sandwich	hypothetical protein PF0899 fold	ATP synthase, E subunit, C-terminal	CATH (utative)
J	3.30.2320.30	Alpha Beta	2-Layer Sandwich	hypothetical protein PF0899 fold	ATP synthase, E subunit, C-terminal	CATH (utative)
K	3.30.2320.30	Alpha Beta	2-Layer Sandwich	hypothetical protein PF0899 fold	ATP synthase, E subunit, C-terminal	CATH (utative)
L	3.40.50.10580	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	ATPase, V1 complex, subunit F	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00006	ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)	ATP synthase alpha/beta family, nucleotide-binding domain	This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	Domain
A, B, C	PF20520	V0 complex accessory subunit Ac45/VOA1 transmembrane domain (Ac45-VOA1_TM)	V0 complex accessory subunit Ac45/VOA1 transmembrane domain	This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homologue V0 assembly protein 1 (VOA1) whic ...	This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homologue V0 assembly protein 1 (VOA1) which are essential for V0 ATPase assembly, stability and function [1,2]. In humans, mutations of ATP6AP1 cause immunodeficiency with hypogammaglobulinemia, hepatopathy and neurocognitive abnormalities [3]. This entry also includes ER membrane BIG1 proteins from yeast, involved in cell wall biogenesis.	Domain
A, B, C	PF22919	C-terminal domain of V and A type ATP synthase (ATP-synt_VA_C)	C-terminal domain of V and A type ATP synthase	This entry represents a small alpha helical domain found at the C-terminus of a variety of ATP synthases.	Domain
A, B, C	PF16886	ATPsynthase alpha/beta subunit barrel-sandwich domain (ATP-synt_ab_Xtn)	ATPsynthase alpha/beta subunit barrel-sandwich domain	This barrel-sandwich domain is found in the alpha-beta catalytic subunit of VATA or V-type proton ATPase catalytic subunit at the N-terminal end. This domain has a circularly permuted topology compared to other barrel-sandwich domains. In VATA barrel ...	This barrel-sandwich domain is found in the alpha-beta catalytic subunit of VATA or V-type proton ATPase catalytic subunit at the N-terminal end. This domain has a circularly permuted topology compared to other barrel-sandwich domains. In VATA barrel-sandwich domain the C-terminal strand is circularly permuted and occupies the spatial position of the N-terminal strand in other hybrid domains.	Domain
A, B, C	PF01496	V-type ATPase 116kDa subunit family (V_ATPase_I)	V-type ATPase 116kDa subunit family	-	Family
A, B, C	PF02874	ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)	ATP synthase alpha/beta family, beta-barrel domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	Domain
A, B, C	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
D, E, F	PF05493	ATP synthase subunit H (ATP_synt_H)	ATP synthase subunit H	-	Family
D, E, F	PF00006	ATP synthase alpha/beta family, nucleotide-binding domain (ATP-synt_ab)	ATP synthase alpha/beta family, nucleotide-binding domain	This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	Domain
D, E, F	PF22919	C-terminal domain of V and A type ATP synthase (ATP-synt_VA_C)	C-terminal domain of V and A type ATP synthase	This entry represents a small alpha helical domain found at the C-terminus of a variety of ATP synthases.	Domain
D, E, F	PF01992	ATP synthase (C/AC39) subunit (vATP-synt_AC39)	ATP synthase (C/AC39) subunit	-	Family
D, E, F	PF02874	ATP synthase alpha/beta family, beta-barrel domain (ATP-synt_ab_N)	ATP synthase alpha/beta family, beta-barrel domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	Domain
G	PF03223	V-ATPase subunit C (V-ATPase_C)	V-ATPase subunit C	-	Family
G	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
H	PF01813	ATP synthase subunit D (ATP-synt_D)	ATP synthase subunit D	-	Family
H	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
I, J, K	PF01991	ATP synthase (E/31 kDa) subunit (vATP-synt_E)	ATP synthase (E/31 kDa) subunit	-	Family
I, J, K	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
L	PF01990	ATP synthase (F/14-kDa) subunit (ATP-synt_F)	ATP synthase (F/14-kDa) subunit	-	Family
L	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
M, N, O	PF03179	Vacuolar (H+)-ATPase G subunit (V-ATPase_G)	Vacuolar (H+)-ATPase G subunit	-	Coiled-coil
M, N, O	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	ATPase H+-transporting V1 subunit A	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic ion channel activity proton channel activity proton-transporting ATP synthase activity, rotational mechanism monoatomic cation channel activity passive transmembrane transporter activity channel activity catalytic activity ligase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular response to stimulus cellular response to chemical stimulus response to stimulus cellular response to oxygen levels response to chemical response to oxygen levels response to abiotic stimulus cellular response to increased oxygen levels response to increased oxygen levels synaptic vesicle maturation cellular localization synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse vesicle organization cellular component organization establishment of localization in cell cellular component organization or biogenesis synaptic vesicle lumen acidification developmental process developmental maturation organelle organization neuron cellular homeostasis	ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase, V1 domain proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain transmembrane transporter complex ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase, V1 domain proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain transmembrane transporter complex membrane-bounded organelle intracellular anatomical structure vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle bounding membrane of organelle vacuolar membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex organelle cytoplasm organelle membrane cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane cytosol intracellular vesicle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle vesicle extrinsic component of synaptic vesicle membrane synapse transport vesicle membrane extrinsic component of organelle membrane presynapse vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane extrinsic component of membrane exocytic vesicle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane cell projection actin-based cell projection microvillus plasma membrane bounded cell projection
T [auth b]	ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	-	ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex, proton-transporting domain cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V0 domain ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex, proton-transporting domain cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V0 domain membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle coated vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane clathrin-coated vesicle coated vesicle organelle membrane clathrin-coated vesicle membrane
U [auth c]	V-type proton ATPase subunit S1	small GTPase binding protein binding binding enzyme binding GTPase binding transporter activator activity molecular function activator activity molecular function regulator activity transporter activity transporter regulator activity ATPase activator activity ATPase regulator activity ATP-dependent activity	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis biological regulation regulation of pH regulation of cellular pH synaptic vesicle maturation intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis biological regulation regulation of pH regulation of cellular pH synaptic vesicle maturation cellular localization transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization neuron cellular homeostasis cellular process cellular response to stimulus cellular response to chemical stimulus response to stimulus cellular response to oxygen levels response to chemical response to oxygen levels response to abiotic stimulus cellular response to increased oxygen levels response to increased oxygen levels multicellular organismal process myeloid leukocyte differentiation cellular developmental process hemopoiesis animal organ development cell development osteoclast development multicellular organism development skeletal system development myeloid cell differentiation cell differentiation bone cell development osteoclast differentiation anatomical structure development myeloid cell development bone development system development leukocyte differentiation protein localization establishment of protein localization nitrogen compound transport establishment of protein localization to plasma membrane endocytic recycling cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane intracellular transport localization within membrane protein localization to membrane endosomal transport vesicle-mediated transport to the plasma membrane endosome to plasma membrane protein transport protein transport macromolecule localization intracellular protein transport	cellular anatomical structure membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex membrane-bounded organelle intracellular anatomical structure cellular anatomical structure membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex membrane-bounded organelle intracellular anatomical structure intracellular membrane-bounded organelle intracellular organelle bounding membrane of organelle organelle endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment cytoplasm organelle membrane endosome membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle synapse transport vesicle membrane presynapse synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane secretory vesicle exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane
V [auth d]	V-type proton ATPase subunit	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity protein-containing complex binding binding	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis localization cellular localization transport establishment of localization in cell intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis localization cellular localization transport establishment of localization in cell vacuolar transport intracellular transport cellular process establishment of localization synaptic vesicle maturation monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation inorganic cation transmembrane transport transmembrane transport organelle organization neuron cellular homeostasis cellular response to stimulus cellular response to chemical stimulus response to stimulus cellular response to oxygen levels response to chemical response to oxygen levels response to abiotic stimulus cellular response to increased oxygen levels response to increased oxygen levels biological regulation intracellular pH reduction regulation of intracellular pH vacuolar acidification regulation of pH regulation of biological quality regulation of cellular pH	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle ATPase dependent transmembrane transport complex membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex, proton-transporting domain cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex proton-transporting V-type ATPase, V0 domain cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane centrosome microtubule organizing center cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton plasma membrane protein complex plasma membrane proton-transporting V-type ATPase complex bounding membrane of organelle vacuolar membrane vacuole vacuolar proton-transporting V-type ATPase complex organelle membrane synapse transport vesicle membrane presynapse vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle exocytic vesicle axon neuron projection axon terminus plasma membrane bounded cell projection cell projection distal axon neuron projection terminus
W [auth e]	V-type proton ATPase subunit e 2	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport synaptic vesicle maturation cellular localization transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport synaptic vesicle maturation cellular localization homeostatic process synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse vesicle organization cellular component organization establishment of localization in cell cellular component organization or biogenesis synaptic vesicle lumen acidification developmental process developmental maturation organelle organization cellular homeostasis neuron cellular homeostasis	membrane-bounded organelle intracellular anatomical structure synapse intracellular vesicle transport vesicle membrane endomembrane system intracellular organelle presynapse cellular anatomical structure bounding membrane of organelle cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane membrane-bounded organelle intracellular anatomical structure synapse intracellular vesicle transport vesicle membrane endomembrane system intracellular organelle presynapse cellular anatomical structure bounding membrane of organelle cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle membrane exocytic vesicle membrane intracellular membrane-bounded organelle cytoplasmic vesicle membrane organelle secretory vesicle cytoplasm organelle membrane exocytic vesicle ATPase dependent transmembrane transport complex protein-containing complex ATPase complex vacuolar proton-transporting V-type ATPase, V0 domain membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex proton-transporting V-type ATPase, V0 domain vacuolar membrane catalytic complex vacuole proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
X [auth f]	Ribonuclease K	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity identical protein binding protein binding binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vesicle organization cellular component organization organelle organization cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis endosome organization intracellular chemical homeostasis cellular component organization or biogenesis regulation of biological quality endosomal lumen acidification monoatomic cation homeostasis endomembrane system organization regulation of cellular pH intracellular monoatomic ion homeostasis import into cell receptor-mediated endocytosis endocytosis vesicle-mediated transport receptor-mediated endocytosis of virus by host cell biological process involved in interspecies interaction between organisms viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell viral process symbiont entry into host endocytosis involved in viral entry into host cell	cellular anatomical structure membrane membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex MLL1/2 complex intracellular membrane-bounded organelle transferase complex intracellular organelle lumen cellular anatomical structure membrane membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex MLL1/2 complex intracellular membrane-bounded organelle transferase complex intracellular organelle lumen intracellular organelle MLL1 complex nucleoplasm organelle lumen organelle methyltransferase complex nuclear lumen ATPase complex intracellular membraneless organelle chromatin chromosome NURF complex ISWI-type complex membraneless organelle SWI/SNF superfamily-type complex
AA [auth i], BA [auth j], CA [auth k], DA [auth l], EA [auth m], AA [auth i], BA [auth j], CA [auth k], DA [auth l], EA [auth m], FA [auth n], GA [auth o], Y [auth g], Z [auth h]	V-type proton ATPase 16 kDa proteolipid subunit	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding	regulation of biological process autophagic cell death regulation of cellular process negative regulation of programmed cell death regulation of autophagic cell death biological regulation negative regulation of biological process negative regulation of autophagic cell death regulation of programmed cell death cell death negative regulation of cellular process cellular process programmed cell death cellular response to stimulus regulation of biological process autophagic cell death regulation of cellular process negative regulation of programmed cell death regulation of autophagic cell death biological regulation negative regulation of biological process negative regulation of autophagic cell death regulation of programmed cell death cell death negative regulation of cellular process cellular process programmed cell death cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of cellular process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling intracellular signal transduction positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade synaptic vesicle maturation cellular localization homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization cellular homeostasis neuron cellular homeostasis	cellular anatomical structure membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex membrane-bounded organelle intracellular anatomical structure cellular anatomical structure membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex membrane-bounded organelle intracellular anatomical structure vacuolar proton-transporting V-type ATPase, V0 domain intracellular organelle bounding membrane of organelle proton-transporting V-type ATPase, V0 domain vacuolar membrane vacuole intracellular membrane-bounded organelle proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex organelle cytoplasm organelle membrane synapse intracellular vesicle transport vesicle membrane endomembrane system presynapse cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
HA [auth p]	Renin receptor	molecular transducer activity signaling receptor activity	regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process peptide hormone processing regulation of systemic arterial blood pressure mediated by a chemical signal system process signaling receptor ligand precursor processing protein maturation circulatory system process proteolysis amide metabolic process protein metabolic process regulation of biological quality blood circulation regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process peptide hormone processing regulation of systemic arterial blood pressure mediated by a chemical signal system process signaling receptor ligand precursor processing protein maturation circulatory system process proteolysis amide metabolic process protein metabolic process regulation of biological quality blood circulation regulation of blood pressure regulation of hormone levels biological regulation regulation of systemic arterial blood pressure by circulatory renin-angiotensin primary metabolic process gene expression macromolecule biosynthetic process hormone metabolic process regulation of systemic arterial blood pressure endocrine process biosynthetic process regulation of angiotensin levels in blood protein processing metabolic process cellular process macromolecule metabolic process angiotensin maturation developmental process anatomical structure morphogenesis head development anatomical structure development head morphogenesis body morphogenesis regulation of transforming growth factor beta production transforming growth factor beta1 production regulation of cellular process positive regulation of biological process regulation of transforming growth factor beta1 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process positive regulation of transforming growth factor beta1 production transforming growth factor beta production positive regulation of cellular process regulation of biosynthetic process regulation of biological process regulation of macromolecule metabolic process regulation of gene expression positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of transforming growth factor beta production positive regulation of cytokine production regulation of metabolic process cellular response to stimulus regulation of signaling response to stimulus signaling regulation of signal transduction regulation of MAPK cascade intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette MAPK cascade regulation of cell communication signal transduction homeostatic process intracellular pH reduction regulation of intracellular pH cellular component organization lysosome organization vacuolar acidification lysosomal lumen acidification intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis cellular component organization or biogenesis monoatomic cation homeostasis regulation of lysosomal lumen pH regulation of cellular pH intracellular monoatomic ion homeostasis vacuole organization lytic vacuole organization organelle organization cellular homeostasis chemical homeostasis positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway Wnt signaling pathway cell surface receptor signaling pathway regulation of Wnt signaling pathway positive regulation of signaling synaptic vesicle maturation cellular localization transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization localization establishment of localization in cell monoatomic ion transport synaptic vesicle lumen acidification monoatomic cation transport proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport neuron cellular homeostasis epithelium development neural tube development tube development chordate embryonic development anterior/posterior pattern specification pattern specification process nervous system development embryo development tissue development regionalization multicellular organism development embryo development ending in birth or egg hatching rostrocaudal neural tube patterning neural tube patterning system development regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway central nervous system maturation central nervous system development anatomical structure maturation pigmentation eye pigmentation developmental pigmentation	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell surface external side of plasma membrane side of membrane apical part of cell cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell surface external side of plasma membrane side of membrane apical part of cell apical plasma membrane ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex transporter complex intracellular organelle bounding membrane of organelle proton-transporting two-sector ATPase complex vacuolar membrane catalytic complex vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle cytoplasm organelle membrane lytic vacuole lysosome intracellular vesicle coated vesicle membrane cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle clathrin-coated vesicle coated vesicle vesicle clathrin-coated vesicle membrane organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane autophagosome membrane autophagosome lytic vacuole membrane lysosomal membrane vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain dendritic spine somatodendritic compartment neuron projection membrane dendrite membrane dendritic tree cell leading edge neuron spine neuron projection leading edge membrane plasma membrane bounded cell projection dendritic spine membrane cell projection dendrite cell projection membrane endosome membrane endosome transport vesicle membrane presynapse synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane secretory vesicle exocytic vesicle axon cell body extracellular region extracellular space
D, E, F	V-type proton ATPase subunit B, brain isoform	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	nucleoside phosphate metabolic process ribose phosphate metabolic process purine nucleoside triphosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process nucleoside phosphate metabolic process ribose phosphate metabolic process purine nucleoside triphosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process homeostatic process biological regulation cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis synaptic vesicle maturation cellular localization transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization neuron cellular homeostasis intracellular pH reduction regulation of intracellular pH vacuolar acidification regulation of biological quality	ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain vacuolar membrane catalytic complex membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle cytoplasm organelle membrane pigment granule intracellular vesicle melanosome cytoplasmic vesicle vesicle cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane ruffle cell projection cell leading edge plasma membrane bounded cell projection cytosol actin-based cell projection microvillus extrinsic component of synaptic vesicle membrane synapse transport vesicle membrane extrinsic component of organelle membrane endomembrane system presynapse vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle extrinsic component of membrane exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
G	V-type proton ATPase subunit C 1	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	synaptic vesicle maturation cellular localization homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport synaptic vesicle maturation cellular localization homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization cellular homeostasis neuron cellular homeostasis cellular process	ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase, V1 domain proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain transmembrane transporter complex ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane membrane protein complex proton-transporting V-type ATPase, V1 domain proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex cellular anatomical structure proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain transmembrane transporter complex cell periphery plasma membrane membrane-bounded organelle intracellular anatomical structure vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle bounding membrane of organelle vacuolar membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex organelle cytoplasm organelle membrane apical part of cell extrinsic component of synaptic vesicle membrane synapse intracellular vesicle transport vesicle membrane extrinsic component of organelle membrane endomembrane system presynapse cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle extrinsic component of membrane exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
H	ATPase H+-transporting V1 subunit D	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	protein localization localization cellular localization protein localization to cilium protein localization to organelle cellular macromolecule localization macromolecule localization cellular process synaptic vesicle maturation homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport protein localization localization cellular localization protein localization to cilium protein localization to organelle cellular macromolecule localization macromolecule localization cellular process synaptic vesicle maturation homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization cellular homeostasis neuron cellular homeostasis organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly cilium assembly cilium organization cell projection assembly	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cell periphery plasma membrane extrinsic component of synaptic vesicle membrane synapse intracellular vesicle transport vesicle membrane extrinsic component of organelle membrane endomembrane system presynapse bounding membrane of organelle cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle exocytic vesicle membrane intracellular membrane-bounded organelle cytoplasmic vesicle membrane secretory vesicle cytoplasm organelle membrane extrinsic component of membrane exocytic vesicle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
I, J, K	V-type proton ATPase subunit E 1	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity ATPase binding protein binding binding enzyme binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport synaptic vesicle maturation cellular localization transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport synaptic vesicle maturation cellular localization homeostatic process synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse vesicle organization cellular component organization establishment of localization in cell cellular component organization or biogenesis synaptic vesicle lumen acidification developmental process developmental maturation organelle organization cellular homeostasis neuron cellular homeostasis	ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex proton-transporting V-type ATPase, V1 domain transporter complex vacuolar proton-transporting V-type ATPase, V1 domain intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex, catalytic domain vacuolar membrane catalytic complex membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle cytoplasm organelle membrane cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle vesicle cytosol cell projection actin-based cell projection microvillus plasma membrane bounded cell projection extrinsic component of synaptic vesicle membrane synapse transport vesicle membrane extrinsic component of organelle membrane presynapse vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle extrinsic component of membrane exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
L	V-type proton ATPase subunit F	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	synaptic vesicle maturation cellular localization homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport synaptic vesicle maturation cellular localization homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization cellular homeostasis neuron cellular homeostasis cellular process	ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex transporter complex intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex vacuolar membrane catalytic complex ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex transporter complex intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex vacuolar membrane catalytic complex membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle cytoplasm organelle membrane proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex, catalytic domain extrinsic component of synaptic vesicle membrane synapse intracellular vesicle transport vesicle membrane extrinsic component of organelle membrane endomembrane system presynapse cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle extrinsic component of membrane exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane
M, N, O	V-type proton ATPase subunit G	monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled ion transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport synaptic vesicle maturation cellular localization transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport synaptic vesicle maturation cellular localization homeostatic process synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse vesicle organization cellular component organization establishment of localization in cell cellular component organization or biogenesis synaptic vesicle lumen acidification developmental process developmental maturation organelle organization cellular homeostasis neuron cellular homeostasis	ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex transporter complex intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex vacuolar membrane catalytic complex ATPase dependent transmembrane transport complex membrane-bounded organelle protein-containing complex ATPase complex intracellular anatomical structure membrane protein complex proton-transporting V-type ATPase complex transporter complex intracellular organelle cellular anatomical structure bounding membrane of organelle proton-transporting two-sector ATPase complex vacuolar membrane catalytic complex membrane vacuole intracellular membrane-bounded organelle vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle cytoplasm organelle membrane synapse intracellular vesicle transport vesicle membrane endomembrane system presynapse cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle exocytic vesicle proton-transporting V-type ATPase, V1 domain vacuolar proton-transporting V-type ATPase, V1 domain proton-transporting two-sector ATPase complex, catalytic domain extrinsic component of synaptic vesicle membrane extrinsic component of organelle membrane extrinsic component of membrane
P [auth Q], Q [auth R], R [auth S]	Effector protein SidK	-	-	-
S [auth a]	V-type proton ATPase 116 kDa subunit a isoform 1	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity ATPase binding protein binding binding enzyme binding	regulation of biological process catabolic process regulation of cellular process macroautophagy autophagy biological regulation regulation of catabolic process regulation of autophagy regulation of macroautophagy cellular process metabolic process process utilizing autophagic mechanism regulation of metabolic process synaptic vesicle maturation regulation of biological process catabolic process regulation of cellular process macroautophagy autophagy biological regulation regulation of catabolic process regulation of autophagy regulation of macroautophagy cellular process metabolic process process utilizing autophagic mechanism regulation of metabolic process synaptic vesicle maturation cellular localization homeostatic process transport monoatomic ion transmembrane transport synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse monoatomic cation transmembrane transport vesicle organization cellular component organization localization establishment of localization in cell monoatomic ion transport cellular component organization or biogenesis synaptic vesicle lumen acidification monoatomic cation transport developmental process proton transmembrane transport inorganic ion transmembrane transport developmental maturation establishment of localization inorganic cation transmembrane transport transmembrane transport organelle organization cellular homeostasis neuron cellular homeostasis intracellular pH reduction regulation of intracellular pH vacuolar acidification chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle axon cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle axon synapse neuron projection axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon terminal bouton cell junction neuron projection terminus ATPase dependent transmembrane transport complex protein-containing complex ATPase complex vacuolar proton-transporting V-type ATPase, V0 domain membrane protein complex proton-transporting V-type ATPase complex transporter complex bounding membrane of organelle proton-transporting two-sector ATPase complex proton-transporting V-type ATPase, V0 domain vacuolar membrane catalytic complex vacuole proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex organelle membrane perinuclear region of cytoplasm cell periphery plasma membrane transport vesicle membrane endomembrane system vesicle membrane synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle exocytic vesicle coated vesicle membrane clathrin-coated vesicle coated vesicle clathrin-coated vesicle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR022878	V-type ATP synthase catalytic alpha chain	Family
A, B, C	IPR024034	ATPase, F1/V1 complex, beta/alpha subunit, C-terminal	Homologous Superfamily
A, B, C	IPR036121	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily	Homologous Superfamily
A, B, C	IPR031686	ATPsynthase alpha/beta subunit, barrel-sandwich domain	Domain
A, B, C	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
A, B, C	IPR005725	ATPase, V1 complex, subunit A	Family
A, B, C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B, C	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	Domain
A, B, C	IPR023366	ATP synthase subunit alpha, N-terminal domain-like superfamily	Homologous Superfamily
A, B, C	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
A, B, C	IPR055190	ATP synthase A/B type, C-terminal domain	Domain
T [auth b]	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
T [auth b]	IPR000245	V-ATPase proteolipid subunit	Family
T [auth b]	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
U [auth c]	IPR046755	V-type proton ATPase subunit S1, luminal domain	Domain
U [auth c]	IPR008388	V0 complex accessory subunit Ac45	Family
U [auth c]	IPR046756	V-type proton ATPase subunit S1/VOA1, transmembrane domain	Domain
V [auth d]	IPR036079	V-type ATP synthase subunit c/d subunit superfamily	Homologous Superfamily
V [auth d]	IPR035067	V-type ATPase subunit C/d	Homologous Superfamily
V [auth d]	IPR044911	V-type ATP synthase c/d subunit, domain 3 superfamily	Homologous Superfamily
V [auth d]	IPR016727	ATPase, V0 complex, subunit d	Family
V [auth d]	IPR002843	ATPase, V0 complex, c/d subunit	Family
W [auth e]	IPR017385	ATPase, V0 complex, subunit e1/e2, metazoa	Family
W [auth e]	IPR008389	ATPase, V0 complex, subunit e1/e2	Family
X [auth f]	IPR026770	Ribonuclease kappa	Family
AA [auth i], BA [auth j], CA [auth k], DA [auth l], EA [auth m], AA [auth i], BA [auth j], CA [auth k], DA [auth l], EA [auth m], FA [auth n], GA [auth o], Y [auth g], Z [auth h]	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
AA [auth i], BA [auth j], CA [auth k], DA [auth l], EA [auth m], AA [auth i], BA [auth j], CA [auth k], DA [auth l], EA [auth m], FA [auth n], GA [auth o], Y [auth g], Z [auth h]	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
AA [auth i], BA [auth j], CA [auth k], DA [auth l], EA [auth m], AA [auth i], BA [auth j], CA [auth k], DA [auth l], EA [auth m], FA [auth n], GA [auth o], Y [auth g], Z [auth h]	IPR011555	V-ATPase proteolipid subunit C, eukaryotic	Family
AA [auth i], BA [auth j], CA [auth k], DA [auth l], EA [auth m], AA [auth i], BA [auth j], CA [auth k], DA [auth l], EA [auth m], FA [auth n], GA [auth o], Y [auth g], Z [auth h]	IPR000245	V-ATPase proteolipid subunit	Family
HA [auth p]	IPR012493	Renin receptor-like	Family
D, E, F	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	Domain
D, E, F	IPR005723	ATPase, V1 complex, subunit B	Family
D, E, F	IPR022879	V-type ATP synthase regulatory subunit B/beta	Family
D, E, F	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	Active Site
D, E, F	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	Domain
D, E, F	IPR055190	ATP synthase A/B type, C-terminal domain	Domain
D, E, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
G	IPR004907	ATPase, V1 complex, subunit C	Family
G	IPR036132	Vacuolar ATP synthase subunit C superfamily	Homologous Superfamily
H	IPR002699	ATPase, V1 complex, subunit D	Family
I, J, K	IPR038495	V-type ATPase subunit E, C-terminal domain superfamily	Homologous Superfamily
I, J, K	IPR002842	V-type ATPase subunit E	Family
L	IPR005772	ATPase, V1 complex, subunit F, eukaryotic	Family
L	IPR036906	ATPase, V1 complex, subunit F superfamily	Homologous Superfamily
L	IPR008218	ATPase, V1 complex, subunit F	Family
M, N, O	IPR005124	Vacuolar (H+)-ATPase G subunit	Family
S [auth a]	IPR026028	ATPase, V0 complex, subunit 116kDa, eukaryotic	Family
S [auth a]	IPR002490	V-type ATPase, V0 complex, 116kDa subunit family	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
AA [auth i], BA [auth j], CA [auth k], D, DA [auth l] AA [auth i], BA [auth j], CA [auth k], D, DA [auth l], E, EA [auth m], F, FA [auth n], G, GA [auth o], HA [auth p], I, J, K, L, S [auth a], T [auth b], U [auth c], W [auth e], X [auth f], Y [auth g], Z [auth h]	OPM	Transmembrane	Alpha-helical polytopic	Proton or Sodium translocating F-type, V-type and A-type ATPases	V-type and F-type ATPases

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
AA [auth i], BA [auth j], CA [auth k], D, DA [auth l] AA [auth i], BA [auth j], CA [auth k], D, DA [auth l], E, EA [auth m], F, FA [auth n], G, GA [auth o], HA [auth p], I, J, K, L, S [auth a], T [auth b], U [auth c], W [auth e], X [auth f], Y [auth g], Z [auth h]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
AA [auth i], BA [auth j], CA [auth k], D, DA [auth l] AA [auth i], BA [auth j], CA [auth k], D, DA [auth l], E, EA [auth m], F, FA [auth n], G, GA [auth o], HA [auth p], I, J, K, L, S [auth a], T [auth b], U [auth c], W [auth e], X [auth f], Y [auth g], Z [auth h]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Vacuolar ATPase (V-ATPase)	V-ATPase, composite model rotational state 1 bound to ADP & SidK