Annotations: 7M1Z

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	HMG-CoA_reductase_classII	e7m1zC3	A: alpha arrays	X: RuvA-C	H: HMG-CoA reductase flap domain (From Topology)	T: HMG-CoA reductase flap domain	F: HMG-CoA_reductase_classII	ECOD (1.6)
C	HMG-CoA_red_2nd	e7m1zC1	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: NAD-binding domain of HMG-CoA reductase	F: HMG-CoA_red_2nd	ECOD (1.6)
C	HMG-CoA_red_1st	e7m1zC2	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: Substrate-binding domain of HMG-CoA reductase	F: HMG-CoA_red_1st	ECOD (1.6)
A	HMG-CoA_red_2nd	e7m1zA1	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: NAD-binding domain of HMG-CoA reductase	F: HMG-CoA_red_2nd	ECOD (1.6)
A	HMG-CoA_red_1st	e7m1zA2	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: Substrate-binding domain of HMG-CoA reductase	F: HMG-CoA_red_1st	ECOD (1.6)
B	HMG-CoA_reductase_classII	e7m1zB3	A: alpha arrays	X: RuvA-C	H: HMG-CoA reductase flap domain (From Topology)	T: HMG-CoA reductase flap domain	F: HMG-CoA_reductase_classII	ECOD (1.6)
B	HMG-CoA_red_2nd	e7m1zB1	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: NAD-binding domain of HMG-CoA reductase	F: HMG-CoA_red_2nd	ECOD (1.6)
B	HMG-CoA_red_1st	e7m1zB2	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: Substrate-binding domain of HMG-CoA reductase	F: HMG-CoA_red_1st	ECOD (1.6)
D	HMG-CoA_red_2nd	e7m1zD2	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: NAD-binding domain of HMG-CoA reductase	F: HMG-CoA_red_2nd	ECOD (1.6)
D	HMG-CoA_red_1st	e7m1zD1	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: Substrate-binding domain of HMG-CoA reductase	F: HMG-CoA_red_1st	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00368	Hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA_red)	Hydroxymethylglutaryl-coenzyme A reductase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Hydroxymethylglutaryl-CoA reductase, degradative	binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors hydroxymethylglutaryl-CoA reductase (NADPH) activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors hydroxymethylglutaryl-CoA reductase (NADPH) activity cation binding ion binding metal ion binding	nucleoside phosphate metabolic process primary metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process cellular process sulfur compound metabolic process small molecule metabolic process amide metabolic process phosphorus metabolic process coenzyme A metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR009023	Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR002155	Thiolase	Family
A, B, C, D	IPR004553	Hydroxymethylglutaryl-CoA reductase, bacterial-type	Family
A, B, C, D	IPR016039	Thiolase-like	Homologous Superfamily
A, B, C, D	IPR009029	Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR023074	Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily	Homologous Superfamily
A, B, C, D	IPR020617	Thiolase, C-terminal	Domain
A, B, C, D	IPR020616	Thiolase, N-terminal	Domain
A, B, C, D	IPR020610	Thiolase, active site	Active Site
A, B, C, D	IPR020615	Thiolase, acyl-enzyme intermediate active site	Active Site
A, B, C, D	IPR002202	Hydroxymethylglutaryl-CoA reductase, class I/II	Family
A, B, C, D	IPR023076	Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.