7AC8

Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d7ac8c_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	Histidine biosynthesis enzymes	Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
E	d7ac8e_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	Histidine biosynthesis enzymes	Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
A	d7ac8a_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	Histidine biosynthesis enzymes	Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
D	d7ac8d_	Alpha and beta proteins (a/b)	Flavodoxin-like	Class I glutamine amidotransferase-like	Class I glutamine amidotransferases (GAT)	GAT subunit, HisH, (or domain) of imidazoleglycerolphosphate synthase HisF	(Thermotoga maritima MSB8 ) [TaxId: 243274 ],	SCOPe (2.08)
B	d7ac8b_	Alpha and beta proteins (a/b)	Flavodoxin-like	Class I glutamine amidotransferase-like	Class I glutamine amidotransferases (GAT)	GAT subunit, HisH, (or domain) of imidazoleglycerolphosphate synthase HisF	(Thermotoga maritima MSB8 ) [TaxId: 243274 ],	SCOPe (2.08)
F	d7ac8f_	Alpha and beta proteins (a/b)	Flavodoxin-like	Class I glutamine amidotransferase-like	Class I glutamine amidotransferases (GAT)	GAT subunit, HisH, (or domain) of imidazoleglycerolphosphate synthase HisF	(Thermotoga maritima MSB8 ) [TaxId: 243274 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8043236	3000216	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8043236	3000216	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8043236	3000216	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Class I glutamine amidotransferase-like	8037966	3001405	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Class I glutamine amidotransferase-like	8037966	3001405	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Class I glutamine amidotransferase-like	8037966	3001405	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	His_biosynth	e7ac8C1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: His_biosynth	ECOD (1.6)
E	His_biosynth	e7ac8E1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: His_biosynth	ECOD (1.6)
A	His_biosynth	e7ac8A1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: His_biosynth	ECOD (1.6)
D	GATase	e7ac8D1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: GATase	ECOD (1.6)
B	GATase	e7ac8B1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: GATase	ECOD (1.6)
F	GATase	e7ac8F1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: GATase	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E	PF00977	Histidine biosynthesis protein (His_biosynth)	Histidine biosynthesis protein	-	Family
B, D, F	PF00117	Glutamine amidotransferase class-I (GATase)	Glutamine amidotransferase class-I	-	Domain
B, D, F	PF07685	CobB/CobQ-like glutamine amidotransferase domain (GATase_3)	CobB/CobQ-like glutamine amidotransferase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E	Imidazole glycerol phosphate synthase subunit HisF	lyase activity catalytic activity imidazoleglycerol-phosphate synthase activity pentosyltransferase activity glycosyltransferase activity transferase activity	oxoacid metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process imidazole-containing compound metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process small molecule metabolic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process small molecule biosynthetic process L-histidine metabolic process carboxylic acid metabolic process primary metabolic process oxoacid metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process imidazole-containing compound metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process small molecule metabolic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process small molecule biosynthetic process L-histidine metabolic process carboxylic acid metabolic process primary metabolic process L-amino acid biosynthetic process L-amino acid metabolic process proteinogenic amino acid metabolic process amino acid biosynthetic process biosynthetic process L-histidine biosynthetic process proteinogenic amino acid biosynthetic process metabolic process cellular process alpha-amino acid biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm
B, D, F	Imidazole glycerol phosphate synthase subunit HisH	lyase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides glutaminase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds imidazoleglycerol-phosphate synthase activity pentosyltransferase activity glycosyltransferase activity transferase activity	glutamine metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process glutamine family amino acid metabolic process proteinogenic amino acid metabolic process metabolic process cellular process small molecule metabolic process organic acid biosynthetic process glutamine metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process glutamine family amino acid metabolic process proteinogenic amino acid metabolic process metabolic process cellular process small molecule metabolic process organic acid biosynthetic process imidazole-containing compound metabolic process carboxylic acid biosynthetic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process small molecule biosynthetic process L-histidine metabolic process L-amino acid biosynthetic process amino acid biosynthetic process biosynthetic process L-histidine biosynthetic process proteinogenic amino acid biosynthetic process alpha-amino acid biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E	IPR011060	Ribulose-phosphate binding barrel	Homologous Superfamily
A, C, E	IPR004651	Histidine biosynthesis, HisF	Family
A, C, E	IPR050064	Imidazole glycerol phosphate synthase HisA/HisF	Family
A, C, E	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A, C, E	IPR006062	Histidine biosynthesis protein	Family
B, D, F	IPR029062	Class I glutamine amidotransferase-like	Homologous Superfamily
B, D, F	IPR017926	Glutamine amidotransferase	Domain
B, D, F	IPR010139	Imidazole glycerol phosphate synthase, subunit H	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.