Annotations: 7CEE

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	alpha/beta-Hydrolases	8102701	3000102	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	alpha/beta-Hydrolases	8102701	3000102	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	COesterase	e7ceeA1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: COesterase	ECOD (1.6)
B	COesterase	e7ceeB1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: COesterase	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Neuroligin-3	cell adhesion molecule binding protein binding binding signaling receptor binding neurexin family protein binding	regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation presynapse organization regulation of terminal button organization terminal button organization cellular component organization regulation of synapse organization cell junction organization regulation of presynapse organization cellular process regulation of synapse structure or activity synapse organization regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation presynapse organization regulation of terminal button organization terminal button organization cellular component organization regulation of synapse organization cell junction organization regulation of presynapse organization cellular process regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication positive regulation of response to stimulus synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction positive regulation of cellular process trans-synaptic signaling regulation of signaling cell surface receptor signaling pathway nervous system process cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication excitatory postsynaptic potential regulation of membrane potential positive regulation of signaling rhythmic synaptic transmission positive regulation of nervous system development positive regulation of cellular component organization regulation of developmental process regulation of nervous system development positive regulation of developmental process cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly anatomical structure development regulation of synapse assembly system development developmental process regulation of multicellular organismal development positive regulation of cellular component biogenesis nervous system development regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly positive regulation of multicellular organismal process synapse assembly positive regulation of synapse assembly cellular developmental process neurogenesis central nervous system development gliogenesis oligodendrocyte differentiation glial cell differentiation cell differentiation regulation of localization transport regulation of signaling receptor activity monoatomic ion transmembrane transport regulation of AMPA receptor activity regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of transporter activity positive regulation of molecular function localization positive regulation of monoatomic ion transport positive regulation of transmembrane transport monoatomic ion transport positive regulation of monoatomic ion transmembrane transport regulation of monoatomic ion transmembrane transporter activity regulation of transport positive regulation of signaling receptor activity regulation of monoatomic ion transport establishment of localization transmembrane transport regulation of molecular function positive regulation of AMPA receptor activity regulation of transmembrane transport positive regulation of transport positive regulation of transporter activity regulation of neurotransmitter receptor activity positive regulation of ion transmembrane transporter activity long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of long-term synaptic potentiation cell projection organization neuron projection development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendritic spine morphogenesis dendritic spine development postsynapse organization dendritic spine organization regulation of cell projection organization regulation of postsynapse organization generation of neurons regulation of neuron projection development plasma membrane bounded cell projection morphogenesis cell development cell morphogenesis dendrite development regulation of anatomical structure morphogenesis plasma membrane bounded cell projection organization dendrite morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron development regulation of dendritic spine morphogenesis neuron projection organization regulation of plasma membrane bounded cell projection organization synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic positive regulation of synaptic transmission, glutamatergic membrane organization membrane biogenesis presynaptic membrane assembly membrane assembly presynaptic membrane organization presynapse assembly regulation of NMDA receptor activity respiratory gaseous exchange by respiratory system respiratory system process regulation of respiratory gaseous exchange regulation of respiratory system process regulation of respiratory gaseous exchange by nervous system process vesicle localization cellular localization synaptic vesicle clustering synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse organelle localization establishment of localization in cell positive regulation of synaptic vesicle clustering regulation of synaptic vesicle clustering synaptic vesicle localization response to light stimulus learning learning or memory visual learning visual behavior cognition associative learning behavior response to radiation response to abiotic stimulus glutamate receptor signaling pathway positive regulation of glutamate receptor signaling pathway regulation of glutamate receptor signaling pathway negative regulation of biological process negative regulation of dendritic spine morphogenesis negative regulation of cellular component organization negative regulation of dendritic spine development regulation of dendritic spine development negative regulation of cellular process negative regulation of cell projection organization negative regulation of developmental process negative regulation of neuron projection development cell adhesion cell-cell adhesion neuron cell-cell adhesion inhibitory postsynaptic potential biological process involved in intraspecies interaction between organisms social behavior negative regulation of excitatory postsynaptic potential postsynaptic membrane assembly postsynapse assembly postsynaptic membrane organization axon extension axonogenesis developmental growth cell growth neuron projection extension developmental cell growth growth axon development developmental growth involved in morphogenesis import into cell receptor-mediated endocytosis endocytosis	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell surface membrane-bounded organelle intracellular anatomical structure intracellular vesicle cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane cell surface membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle endocytic vesicle excitatory synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002018	Carboxylesterase, type B	Domain
A, B	IPR019819	Carboxylesterase type B, conserved site	Conserved Site
A, B	IPR000460	Neuroligin	Family
A, B	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
A, B	IPR051093	Neuroligin and Bile salt-activated lipase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.