Annotations: 7EDX

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Rap30/74 heterodimerisation domain-like	8054050	3000142	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	Core histone-like	8042407	3001387	SCOP2B (2022-06-29)
T [auth d]	SCOP2B Superfamily	Core histone-like	8042407	3001387	SCOP2B (2022-06-29)
D [auth E]	SCOP2B Superfamily	Taf5 N-terminal domain-like	8034920	3001495	SCOP2B (2022-06-29)
U [auth e]	SCOP2B Superfamily	Taf5 N-terminal domain-like	8034920	3001495	SCOP2B (2022-06-29)
E [auth F]	SCOP2B Superfamily	Core histone-like	8081687	3001387	SCOP2B (2022-06-29)
V [auth f]	SCOP2B Superfamily	Core histone-like	8081687	3001387	SCOP2B (2022-06-29)
F [auth G]	SCOP2B Superfamily	Rap30/74 heterodimerisation domain-like	8054049	3000142	SCOP2B (2022-06-29)
G [auth H]	SCOP2B Superfamily	Core histone-like	8053232	3001387	SCOP2B (2022-06-29)
I [auth J]	SCOP2B Superfamily	Core histone-like	8053233	3001387	SCOP2B (2022-06-29)
X [auth j]	SCOP2B Superfamily	Core histone-like	8053233	3001387	SCOP2B (2022-06-29)
J [auth L]	SCOP2B Superfamily	Core histone-like	8042408	3001387	SCOP2B (2022-06-29)
Z [auth l]	SCOP2B Superfamily	Core histone-like	8042408	3001387	SCOP2B (2022-06-29)
K [auth O]	SCOP2B Superfamily	Transcription factor IIA (TFIIA), beta-barrel domain	8037007	3001281	SCOP2B (2022-06-29)
K [auth O]	SCOP2B Superfamily	Transcription factor IIA (TFIIA), alpha-helical domain	8037005	3001887	SCOP2B (2022-06-29)
L [auth P]	SCOP2B Superfamily	TATA-box binding protein-like	8036293	3000705	SCOP2B (2022-06-29)
L [auth P]	SCOP2B Superfamily	TATA-box binding protein-like	8036295	3000705	SCOP2B (2022-06-29)
M [auth Q]	SCOP2B Superfamily	Transcription factor IIA (TFIIA), beta-barrel domain	8037002	3001281	SCOP2B (2022-06-29)
M [auth Q]	SCOP2B Superfamily	Transcription factor IIA (TFIIA), alpha-helical domain	8037001	3001887	SCOP2B (2022-06-29)
N [auth R]	SCOP2B Superfamily	Cyclin-like	8043882	3000768	SCOP2B (2022-06-29)
N [auth R]	SCOP2B Superfamily	Cyclin-like	8043880	3000768	SCOP2B (2022-06-29)
P [auth T]	SCOP2B Superfamily	Rap30/74 heterodimerisation domain-like	8003550	3000142	SCOP2B (2022-06-29)
S [auth c]	SCOP2B Superfamily	Core histone-like	8086844	3001387	SCOP2B (2022-06-29)
Y [auth k]	SCOP2B Superfamily	Core histone-like	8036824	3001387	SCOP2B (2022-06-29)
AA [auth m]	SCOP2B Superfamily	Core histone-like	8036818	3001387	SCOP2B (2022-06-29)
EA [auth r]	SCOP2B Superfamily	HRDC-like	8101241	3000132	SCOP2B (2022-06-29)
GA [auth t]	SCOP2B Superfamily	RPB6/omega subunit-like	8106082	3000189	SCOP2B (2022-06-29)
JA [auth x]	SCOP2B Superfamily	RNA polymerase subunit RPB10	8101287	3001213	SCOP2B (2022-06-29)
KA [auth y]	SCOP2B Superfamily	RBP11-like subunits of RNA polymerase	8080728	3001655	SCOP2B (2022-06-29)
LA [auth z]	SCOP2B Superfamily	RNA polymerase subunits	8103068	3001823	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Peptidase_M1_2	e7edxB3	A: beta sandwiches	X: Baculovirus p35 protein-related (From Topology)	H: Baculovirus p35 protein-related (From Topology)	T: Baculovirus p35 protein-related	F: Peptidase_M1_2	ECOD (1.6)
B	CLASP_N_2	e7edxB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: CLASP_N_2	ECOD (1.6)
B	Peptidase_M1	e7edxB2	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M1	ECOD (1.6)
D [auth E]	ANAPC4_WD40_2	e7edxE1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: ANAPC4_WD40_2	ECOD (1.6)
D [auth E]	TFIID_NTD2	e7edxE2	A: alpha superhelices	X: Taf5 N-terminal domain-like (From Topology)	H: Taf5 N-terminal domain-like (From Topology)	T: Taf5 N-terminal domain-like	F: TFIID_NTD2	ECOD (1.6)
U [auth e]	ANAPC4_WD40_10	e7edxe1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 8-bladed	F: ANAPC4_WD40_10	ECOD (1.6)
U [auth e]	TFIID_NTD2	e7edxe2	A: alpha superhelices	X: Taf5 N-terminal domain-like (From Topology)	H: Taf5 N-terminal domain-like (From Topology)	T: Taf5 N-terminal domain-like	F: TFIID_NTD2	ECOD (1.6)
I [auth J]	TFIID_30kDa	e7edxJ1	A: alpha arrays	X: Histone-like	H: Histone-related	T: Histone	F: TFIID_30kDa	ECOD (1.6)
X [auth j]	TFIID_30kDa	e7edxj1	A: alpha arrays	X: Histone-like	H: Histone-related	T: Histone	F: TFIID_30kDa	ECOD (1.6)
J [auth L]	TFIID_20kDa	e7edxL1	A: alpha arrays	X: Histone-like	H: Histone-related	T: Histone	F: TFIID_20kDa	ECOD (1.6)
K [auth O]	TFIIA_gamma_C	e7edxO2	A: beta duplicates or obligate multimers	X: Transcription factor IIA (TFIIA), beta-barrel domain (From Topology)	H: Transcription factor IIA (TFIIA), beta-barrel domain (From Topology)	T: Transcription factor IIA (TFIIA), beta-barrel domain	F: TFIIA_gamma_C	ECOD (1.6)
K [auth O]	TFIIA_gamma_N	e7edxO1	A: alpha duplicates or obligate multimers	X: TFIIA, alpha-helical domain (From Topology)	H: TFIIA, alpha-helical domain (From Topology)	T: TFIIA, alpha-helical domain	F: TFIIA_gamma_N	ECOD (1.6)
L [auth P]	TBP	e7edxP2	A: a+b two layers	X: TBP-like	H: TATA-box binding protein-like (From Topology)	T: TATA-box binding protein-like	F: TBP	ECOD (1.6)
M [auth Q]	TFIIA_C	e7edxQ1	A: beta duplicates or obligate multimers	X: Transcription factor IIA (TFIIA), beta-barrel domain (From Topology)	H: Transcription factor IIA (TFIIA), beta-barrel domain (From Topology)	T: Transcription factor IIA (TFIIA), beta-barrel domain	F: TFIIA_C	ECOD (1.6)
M [auth Q]	TFIIA_N	e7edxQ2	A: alpha duplicates or obligate multimers	X: TFIIA, alpha-helical domain (From Topology)	H: TFIIA, alpha-helical domain (From Topology)	T: TFIIA, alpha-helical domain	F: TFIIA_N	ECOD (1.6)
N [auth R]	TFIIB	e7edxR3	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: TFIIB	ECOD (1.6)
N [auth R]	TF_Zn_Ribbon	e7edxR1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: TF_Zn_Ribbon	ECOD (1.6)
O [auth S]	TFIIF_alpha_N	e7edxS1	A: beta complex topology	X: triple barrel (From Homology)	H: triple barrel	T: Rap30/74 interaction domains-like	F: TFIIF_alpha_N	ECOD (1.6)
P [auth T]	TFIIF_beta_N_1	e7edxT1	A: beta complex topology	X: triple barrel (From Homology)	H: triple barrel	T: Rap30/74 interaction domains-like	F: TFIIF_beta_N_1	ECOD (1.6)
Y [auth k]	TAFII28	e7edxk1	A: alpha arrays	X: Histone-like	H: Histone-related	T: Histone	F: TAFII28	ECOD (1.6)
BA [auth o]	RNA_pol_Rpb1_2	e7edxo1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: RNA_pol_Rpb1_2	ECOD (1.6)
BA [auth o]	RNA_pol_Rpb1_2_1	e7edxo9	A: a+b two layers	X: MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase (From Topology)	H: MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase (From Topology)	T: MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase	F: RNA_pol_Rpb1_2_1	ECOD (1.6)
BA [auth o]	RNA_pol_Rpb1_7	e7edxo4	A: a+b two layers	X: permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit (From Topology)	H: permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit (From Topology)	T: permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit	F: RNA_pol_Rpb1_7	ECOD (1.6)
BA [auth o]	RNAP_II_Rpb1_C	e7edxo3	A: a+b two layers	X: ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit (From Topology)	H: ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit (From Topology)	T: ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit	F: RNAP_II_Rpb1_C	ECOD (1.6)
BA [auth o]	RNA_pol_Rpb1_1	e7edxo8	A: a+b complex topology	X: N-terminal domain in RNA-polymerase beta-prime subunit (From Topology)	H: N-terminal domain in RNA-polymerase beta-prime subunit (From Topology)	T: N-terminal domain in RNA-polymerase beta-prime subunit	F: RNA_pol_Rpb1_1	ECOD (1.6)
BA [auth o]	RNA_pol_Rpb1_5_3rd	e7edxo5	A: a+b complex topology	X: central helical domain in RNA-polymerase beta-prime subunit (From Topology)	H: central helical domain in RNA-polymerase beta-prime subunit (From Topology)	T: central helical domain in RNA-polymerase beta-prime subunit	F: RNA_pol_Rpb1_5_3rd	ECOD (1.6)
BA [auth o]	RNA_pol_Rpb1_6	e7edxo7	A: a+b complex topology	X: helical domain in yeast RNA-polymerases	H: third helical domain in yeast RNA-polymerase II beta-prime subunit (From Topology)	T: third helical domain in yeast RNA-polymerase II beta-prime subunit	F: RNA_pol_Rpb1_6	ECOD (1.6)
BA [auth o]	RNA_pol_Rpb1_4	e7edxo6	A: a+b complex topology	X: second helical domain in RNA-polymerase beta-prime subunit (From Topology)	H: second helical domain in RNA-polymerase beta-prime subunit (From Topology)	T: second helical domain in RNA-polymerase beta-prime subunit	F: RNA_pol_Rpb1_4	ECOD (1.6)
BA [auth o]	RNA_pol_Rpb1_3	e7edxo2	A: a+b complex topology	X: first helical domain in RNA-polymerase beta-prime subunit (From Topology)	H: first helical domain in RNA-polymerase beta-prime subunit (From Topology)	T: first helical domain in RNA-polymerase beta-prime subunit	F: RNA_pol_Rpb1_3	ECOD (1.6)
CA [auth p]	RNA_pol_Rpb2_6_3rd_2	e7edxp6	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: RNA_pol_Rpb2_6_3rd_2	ECOD (1.6)
CA [auth p]	RNA_pol_Rpb2_6_2nd_1	e7edxp7	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: RNA_pol_Rpb2_6_2nd_1	ECOD (1.6)
CA [auth p]	RNA_pol_Rpb2_3	e7edxp3	A: a+b complex topology	X: N-terminal domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	H: N-terminal domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	T: N-terminal domain in beta subunit of DNA dependent RNA-polymerase	F: RNA_pol_Rpb2_3	ECOD (1.6)
CA [auth p]	RNA_pol_Rpb2_1	e7edxp4	A: a+b complex topology	X: insertion domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	H: insertion domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	T: insertion domain in beta subunit of DNA dependent RNA-polymerase	F: RNA_pol_Rpb2_1	ECOD (1.6)
CA [auth p]	RNA_pol_Rpb2_45_1	e7edxp1	A: a+b complex topology	X: barrel domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	H: barrel domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	T: barrel domain in beta subunit of DNA dependent RNA-polymerase	F: RNA_pol_Rpb2_45_1	ECOD (1.6)
CA [auth p]	RNA_pol_Rpb2_7	e7edxp2	A: a+b complex topology	X: C-terminal domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	H: C-terminal domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	T: C-terminal domain in beta subunit of DNA dependent RNA-polymerase	F: RNA_pol_Rpb2_7	ECOD (1.6)
CA [auth p]	RNA_pol_Rpb2_4	e7edxp5	A: a+b complex topology	X: inserted a+b domain in yeast RNA polymerase beta subunit (From Topology)	H: inserted a+b domain in yeast RNA polymerase beta subunit (From Topology)	T: inserted a+b domain in yeast RNA polymerase beta subunit	F: RNA_pol_Rpb2_4	ECOD (1.6)
DA [auth q]	RNA_pol_L_1	e7edxq1	A: a+b two layers	X: DCoH-like	H: RBP11-like subunits of RNA polymerase (From Topology)	T: RBP11-like subunits of RNA polymerase	F: RNA_pol_L_1	ECOD (1.6)
DA [auth q]	RNA_pol_A_bac_1	e7edxq2	A: a+b complex topology	X: Ribosomal protein TL5/L25 C-terminal domain-like	H: Insert subdomain of RNA polymerase alpha subunit (From Topology)	T: Insert subdomain of RNA polymerase alpha subunit	F: RNA_pol_A_bac_1	ECOD (1.6)
EA [auth r]	RNA_pol_Rpb4	e7edxr1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: RNA_pol_Rpb4	ECOD (1.6)
GA [auth t]	RNA_pol_Rpb6_1	e7edxt1	A: alpha arrays	X: RPB6/omega subunit-like (From Homology)	H: RPB6/omega subunit-like	T: RPB6	F: RNA_pol_Rpb6_1	ECOD (1.6)
HA [auth v]	RNA_pol_Rpb8	e7edxv1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: RNA_pol_Rpb8	ECOD (1.6)
IA [auth w]	RNA_POL_M_15KD	e7edxw1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: RNA_POL_M_15KD	ECOD (1.6)
IA [auth w]	TFIIS_C	e7edxw2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: TFIIS_C	ECOD (1.6)
JA [auth x]	RNA_pol_N	e7edxx1	A: alpha arrays	X: HTH	H: RPB10 (From Topology)	T: RPB10	F: RNA_pol_N	ECOD (1.6)
KA [auth y]	RNA_pol_L_2	e7edxy1	A: a+b two layers	X: DCoH-like	H: RBP11-like subunits of RNA polymerase (From Topology)	T: RBP11-like subunits of RNA polymerase	F: RNA_pol_L_2	ECOD (1.6)
LA [auth z]	DNA_RNApol_7kD	e7edxz1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: DNA_RNApol_7kD	ECOD (1.6)
MA [auth u]	S1_1	e7edxu2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: S1_1	ECOD (1.6)
MA [auth u]	SHS2_Rpb7-N	e7edxu1	A: a+b two layers	X: Dodecin subunit-like	H: Flavin-binding protein dodecin-like (From Topology)	T: Flavin-binding protein dodecin-like	F: SHS2_Rpb7-N	ECOD (1.6)
FA [auth s]	RNA_pol_Rpb5_C	e7edxs1	A: a+b two layers	X: RPB5-like RNA polymerase subunit (From Topology)	H: RPB5-like RNA polymerase subunit (From Topology)	T: RPB5-like RNA polymerase subunit	F: RNA_pol_Rpb5_C	ECOD (1.6)
FA [auth s]	RNA_pol_Rpb5_N	e7edxs2	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Eukaryotic RPB5 N-terminal domain (From Topology)	T: Eukaryotic RPB5 N-terminal domain	F: RNA_pol_Rpb5_N	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF12157	Protein of unknown function (DUF3591) (DUF3591)	Protein of unknown function (DUF3591)	-	Family
D [auth E], U [auth e]	PF04494	WD40 associated region in TFIID subunit, NTD2 domain (TFIID_NTD2)	WD40 associated region in TFIID subunit, NTD2 domain	-	Family
D [auth E], U [auth e]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
E [auth F], V [auth f]	PF07571	TAF6 C-terminal HEAT repeat domain (TAF6_C)	TAF6 C-terminal HEAT repeat domain	-	Repeat
E [auth F], V [auth f]	PF02969	TATA box binding protein associated factor (TAF) (TAF)	TATA box binding protein associated factor (TAF)	TAF proteins adopt a histone-like fold.	Domain
F [auth G]	PF04658	TAFII55 protein conserved region (TAFII55_N)	TAFII55 protein conserved region	-	Family
G [auth H]	PF07524	Bromodomain associated (Bromo_TP)	Bromodomain associated	This domain is predicted to bind DNA [1] and is often found associated with Pfam:PF00439 and in transcription factors. It has a histone-like fold.	Domain
G [auth H]	PF10406	Transcription factor TFIID complex subunit 8 C-term (TAF8_C)	Transcription factor TFIID complex subunit 8 C-term	This is the C-terminal, Delta, part of the TAF8 protein [1]. The N-terminal is generally the histone fold domain, Bromo_TP (Pfam:PF07524). TAF8 is one of the key subunits of the transcription factor for pol II, TFIID. TAF8 is one of the several gener ...	This is the C-terminal, Delta, part of the TAF8 protein [1]. The N-terminal is generally the histone fold domain, Bromo_TP (Pfam:PF07524). TAF8 is one of the key subunits of the transcription factor for pol II, TFIID. TAF8 is one of the several general cofactors which are typically involved in gene activation to bring about the communication between gene-specific transcription factors and components of the general transcription machinery [2].	Domain
I [auth J], X [auth j]	PF03540	Transcription initiation factor TFIID 23-30kDa subunit (TAF10)	Transcription initiation factor TFIID 23-30kDa subunit	-	Family
J [auth L], Z [auth l]	PF03847	Transcription initiation factor TFIID subunit A (TFIID_20kDa)	Transcription initiation factor TFIID subunit A		Domain
K [auth O]	PF02751	Transcription initiation factor IIA, gamma subunit (TFIIA_gamma_C)	Transcription initiation factor IIA, gamma subunit	Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA b ...	Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The C-terminal domain of the gamma subunit is a 12 stranded beta-barrel.	Domain
K [auth O]	PF04997	RNA polymerase Rpb1, domain 1 (RNA_pol_Rpb1_1)	RNA polymerase Rpb1, domain 1	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 1, represents the clamp dom ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 1, represents the clamp domain, which a mobile domain involved in positioning the DNA, maintenance of the transcription bubble and positioning of the nascent RNA strand [1,2].	Domain
L [auth P]	PF04561	RNA polymerase Rpb2, domain 2 (RNA_pol_Rpb2_2)	RNA polymerase Rpb2, domain 2	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA po ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain [1]. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble [1]. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).	Domain
L [auth P]	PF00352	Transcription factor TFIID (or TATA-binding protein, TBP) (TBP)	Transcription factor TFIID (or TATA-binding protein, TBP)		Domain
L [auth P]	PF04563	RNA polymerase beta subunit (RNA_pol_Rpb2_1)	RNA polymerase beta subunit	-	Family
M [auth Q]	PF03153	Transcription factor IIA, alpha/beta subunit (TFIIA)	Transcription factor IIA, alpha/beta subunit	-	Family
M [auth Q]	PF01193	RNA polymerase Rpb3/Rpb11 dimerisation domain (RNA_pol_L)	RNA polymerase Rpb3/Rpb11 dimerisation domain	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation do ...	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation domain of the alpha subunit/Rpb3 is interrupted by an insert domain (Pfam:PF01000). Some of the alpha subunits also contain iron-sulphur binding domains (Pfam:PF00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp.	Domain
M [auth Q]	PF01000	RNA polymerase Rpb3/RpoA insert domain (RNA_pol_A_bac)	RNA polymerase Rpb3/RpoA insert domain	Members of this family include: alpha subunit from eubacteria alpha subunits from chloroplasts Rpb3 subunits from eukaryotes RpoD subunits from archaeal	Domain
N [auth R]	PF00382	Transcription factor TFIIB repeat (TFIIB)	Transcription factor TFIIB repeat		Domain
N [auth R]	PF08271	TFIIB zinc-binding (Zn_Ribbon_TF)	TFIIB zinc-binding	The transcription factor TFIIB contains a zinc-binding motif near the N-terminus. This domain is involved in the interaction with RNA pol II and TFIIF and plays a crucial role in selecting the transcription initiation site. The domain adopts a zinc ...	The transcription factor TFIIB contains a zinc-binding motif near the N-terminus. This domain is involved in the interaction with RNA pol II and TFIIF and plays a crucial role in selecting the transcription initiation site. The domain adopts a zinc ribbon like structure [1].	Domain
N [auth R]	PF03874	RNA polymerase Rpb4 (RNA_pol_Rpb4)	RNA polymerase Rpb4	-	Family
O [auth S]	PF01191	RNA polymerase Rpb5, C-terminal domain (RNA_pol_Rpb5_C)	RNA polymerase Rpb5, C-terminal domain	The assembly domain of Rpb5 [1]. The archaeal equivalent to this domain is subunit H. Subunit H lacks the N-terminal domain.	Domain
O [auth S]	PF03871	RNA polymerase Rpb5, N-terminal domain (RNA_pol_Rpb5_N)	RNA polymerase Rpb5, N-terminal domain	Rpb5 has a bipartite structure which includes a eukaryote-specific N-terminal domain and a C-terminal domain resembling the archaeal RNAP subunit H [1,2]. The N-terminal domain is involved in DNA binding and is part of the jaw module in the RNA p ...	Rpb5 has a bipartite structure which includes a eukaryote-specific N-terminal domain and a C-terminal domain resembling the archaeal RNAP subunit H [1,2]. The N-terminal domain is involved in DNA binding and is part of the jaw module in the RNA pol II structure [3]. This module is important for positioning the downstream DNA.	Domain
P [auth T]	PF01192	RNA polymerase Rpb6 (RNA_pol_Rpb6)	RNA polymerase Rpb6	-	Family
P [auth T]	PF17683	TFIIF, beta subunit N-terminus (TFIIF_beta_N)	TFIIF, beta subunit N-terminus	-	Family
Q [auth X]	PF01194	RNA polymerases N / 8 kDa subunit (RNA_pol_N)	RNA polymerases N / 8 kDa subunit		Domain
R [auth Y]	PF13656	RNA polymerase Rpb3/Rpb11 dimerisation domain (RNA_pol_L_2)	RNA polymerase Rpb3/Rpb11 dimerisation domain	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation do ...	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation domain of the alpha subunit/Rpb3 is interrupted by an insert domain (Pfam:PF01000). Some of the alpha subunits also contain iron-sulphur binding domains (Pfam:PF00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp. Many of the members of this family carry only the N-terminal region of Rpb11.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Transcription initiation factor TFIID subunit 1	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups sequence-specific DNA binding DNA binding binding nucleic acid binding adenyl ribonucleotide binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity DNA-dependent protein kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups sequence-specific DNA binding DNA binding binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T6 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity double-stranded DNA binding core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding histone H3S57 kinase activity protein-lysine-acetyltransferase activity protein N-acetyltransferase activity N-acetyltransferase activity acyltransferase activity histone acetyltransferase activity acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups N-acyltransferase activity histone H4 acetyltransferase activity histone H4K8 acetyltransferase activity histone H3 acetyltransferase activity histone H3K14 acetyltransferase activity transcription factor binding basal transcription machinery binding protein binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding histone H4S1 kinase activity histone H4 kinase activity histone H2B acetyltransferase activity histone H2BK12 acetyltransferase activity histone H2A acetyltransferase activity histone H2AK5 acetyltransferase activity histone H4K5 acetyltransferase activity histone H3T11 kinase activity histone H3S28 kinase activity histone H2B kinase activity histone H2BS36 kinase activity RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding ribosomal protein S6 kinase activity histone H3K36 acetyltransferase activity histone H3S10 kinase activity histone H3K23 acetyltransferase activity histone H2AS121 kinase activity histone H2A kinase activity histone H3K56 acetyltransferase activity histone H3K122 acetyltransferase activity ubiquitin conjugating enzyme activity aminoacyltransferase activity ubiquitin-like protein transferase activity ubiquitin-like protein conjugating enzyme activity ubiquitin-protein transferase activity molecular function inhibitor activity transcription regulator activity molecular function regulator activity transcription regulator inhibitor activity AMP-activated protein kinase activity histone H3K9 acetyltransferase activity histone H3T45 kinase activity eukaryotic translation initiation factor 2alpha kinase activity TBP-class protein binding general transcription initiation factor activity RNA polymerase I general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity histone H3K27 acetyltransferase activity histone H3T3 kinase activity histone H2BS14 kinase activity p53 binding histone H4K12 acetyltransferase activity modification-dependent protein binding lysine-acetylated histone binding histone binding acetylation-dependent protein binding Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity protein heterodimerization activity protein dimerization activity histone H3K4 acetyltransferase activity histone H2AXS139 kinase activity histone H2AX kinase activity protein serine kinase activity histone H3K18 acetyltransferase activity histone H2AK9 acetyltransferase activity histone H2BK5 acetyltransferase activity 3-phosphoinositide-dependent protein kinase activity histone H4K16 acetyltransferase activity histone H2AS1 kinase activity	regulation of protein stability biological regulation regulation of biological quality protein stabilization transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly regulation of protein stability biological regulation regulation of biological quality protein stabilization transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process regulation of protein catabolic process regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition cell cycle regulation of cell cycle cell cycle process negative regulation of post-translational protein modification regulation of protein modification process negative regulation of biological process regulation of protein autoubiquitination regulation of protein ubiquitination protein ubiquitination negative regulation of protein modification process negative regulation of cellular process regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein ubiquitination negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of protein autoubiquitination negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification protein autoubiquitination negative regulation of metabolic process macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal protein phosphorylation phosphorylation phosphate-containing compound metabolic process phosphorus metabolic process mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process negative regulation of RNA biosynthetic process regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process regulation of protein binding positive regulation of molecular function regulation of molecular function positive regulation of protein binding regulation of binding positive regulation of binding positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process regulation of DNA-templated transcription initiation positive regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular response to stimulus positive regulation of DNA-binding transcription factor activity response to stimulus signaling regulation of signaling receptor activity regulation of signal transduction cell communication signal transduction regulation of signaling positive regulation of signaling receptor activity regulation of response to stimulus regulation of DNA-binding transcription factor activity regulation of cell communication positive regulation of androgen receptor activity signal transduction by p53 class mediator intracellular signal transduction regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator negative regulation of gene expression cellular response to stress DNA damage response response to stress negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process negative regulation of ubiquitin-dependent protein catabolic process negative regulation of catabolic process peptidyl-amino acid modification peptidyl-threonine modification peptidyl-threonine phosphorylation protein autophosphorylation protein polyubiquitination peptidyl-serine modification peptidyl-serine phosphorylation cellular response to nitrogen compound cellular response to ATP response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to ATP response to purine-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical transcription initiation at RNA polymerase I promoter transcription by RNA polymerase I developmental process multicellular organismal process head development animal organ development brain development nervous system development multicellular organism development central nervous system development midbrain development anatomical structure development system development response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV	RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen histone methyltransferase complex MLL1/2 complex MLL1 complex methyltransferase complex membraneless organelle intracellular membraneless organelle chromatin chromosome
B	Transcription initiation factor TFIID subunit 2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding chromatin binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity	regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression positive regulation of transcription by RNA polymerase II macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process transcription preinitiation complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization protein-DNA complex assembly RNA polymerase II preinitiation complex assembly mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition cell cycle mitotic cell cycle cell cycle process mitotic cell cycle phase transition cellular response to stimulus response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process	RNA polymerase II transcription regulator complex membrane-bounded organelle transcription factor TFTC complex RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex chromosome transferase complex histone acetyltransferase complex intracellular organelle lumen RNA polymerase II transcription regulator complex membrane-bounded organelle transcription factor TFTC complex RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex chromosome transferase complex histone acetyltransferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm membraneless organelle SAGA-type complex catalytic complex intracellular membraneless organelle chromatin intracellular membrane-bounded organelle acetyltransferase complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex protein acetyltransferase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen transcription factor TFIID complex
C [auth D], T [auth d]	Transcription initiation factor TFIID subunit 4	protein heterodimerization activity protein binding binding protein dimerization activity DNA binding nucleic acid binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding signaling receptor binding DNA-binding transcription factor binding aryl hydrocarbon receptor binding	transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process developmental process multicellular organismal process gonad development reproductive system development reproductive process female gonad development sex differentiation animal organ development female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction multicellular organism development development of primary sexual characteristics anatomical structure development reproductive structure development ovarian follicle development system development mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process cellular response to stimulus response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen membraneless organelle intracellular membraneless organelle chromatin chromosome transcription factor TFTC complex histone acetyltransferase complex SAGA-type complex acetyltransferase complex protein acetyltransferase complex male germ cell nucleus germ cell nucleus histone methyltransferase complex MLL1/2 complex MLL1 complex methyltransferase complex
D [auth E], U [auth e]	Transcription initiation factor TFIID subunit 5	general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity identical protein binding protein binding binding	transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process cellular response to stimulus response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen chromatin chromosome peptidase complex histone acetyltransferase complex acetyltransferase complex protein acetyltransferase complex SAGA-type complex SAGA complex transcription factor TFTC complex
E [auth F], V [auth f]	Transcription initiation factor TFIID subunit 6	protein heterodimerization activity protein binding binding protein dimerization activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding nucleic acid binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity transcription factor binding protein heterodimerization activity protein binding binding protein dimerization activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding nucleic acid binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding signaling receptor binding DNA-binding transcription factor binding aryl hydrocarbon receptor binding	transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process apoptotic process cell death programmed cell death regulation of biological process regulation of cellular process negative regulation of cellular process biological regulation negative regulation of biological process negative regulation of cell cycle cell cycle regulation of cell cycle positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction regulation of intrinsic apoptotic signaling pathway intracellular signal transduction cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction signal transduction intrinsic apoptotic signaling pathway regulation of signaling positive regulation of intracellular signal transduction apoptotic signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of signaling regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of DNA metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen intracellular membraneless organelle chromatin chromosome histone acetyltransferase complex acetyltransferase complex membraneless organelle protein acetyltransferase complex SAGA-type complex SLIK (SAGA-like) complex peptidase complex SAGA complex transcription factor TFTC complex histone methyltransferase complex MLL1/2 complex MLL1 complex methyltransferase complex
F [auth G]	Transcription initiation factor TFIID subunit 7	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding DNA-binding transcription factor binding nuclear vitamin D receptor binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding DNA-binding transcription factor binding nuclear vitamin D receptor binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding nuclear thyroid hormone receptor binding basal transcription machinery binding protein-containing complex binding basal RNA polymerase II transcription machinery binding TFIIH-class transcription factor complex binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding protein heterodimerization activity protein dimerization activity histone acetyltransferase binding enzyme binding P-TEFb complex binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process transcription preinitiation complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly DNA-templated transcription initiation RNA polymerase II preinitiation complex assembly regulation of MHC class I biosynthetic process negative regulation of MHC class I biosynthetic process MHC class I biosynthetic process regulation of MHC class II biosynthetic process negative regulation of MHC class II biosynthetic process MHC class II biosynthetic process localization nitrogen compound transport transport spermine transport polyamine transport establishment of localization regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of catalytic activity regulation of transferase activity negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of DNA-templated transcription initiation positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular response to stimulus intracellular receptor signaling pathway response to stimulus response to lipid signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone signal transduction nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus steroid hormone receptor signaling pathway cellular response to hormone stimulus response to endogenous stimulus estrogen receptor signaling pathway cellular response to chemical stimulus response to chemical cellular response to lipid nuclear receptor-mediated signaling pathway mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process negative regulation of transcription by RNA polymerase II regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process	protein-containing complex transcription regulator complex RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm protein-containing complex transcription regulator complex RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen cytoplasm transcription factor TFTC complex chromosome histone acetyltransferase complex membraneless organelle SAGA-type complex intracellular membraneless organelle chromatin acetyltransferase complex protein acetyltransferase complex male germ cell nucleus germ cell nucleus histone methyltransferase complex MLL1/2 complex MLL1 complex methyltransferase complex
G [auth H]	Transcription initiation factor TFIID subunit 8	protein heterodimerization activity protein binding binding protein dimerization activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity	regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression positive regulation of transcription by RNA polymerase II macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process developmental process cellular developmental process cell differentiation transcription preinitiation complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization protein-DNA complex assembly RNA polymerase II preinitiation complex assembly maintenance of protein location protein localization cellular localization maintenance of protein location in nucleus protein localization to nucleus maintenance of location maintenance of location in cell localization maintenance of protein location in cell cellular macromolecule localization macromolecule localization protein localization to organelle maintenance of protein localization in organelle fat cell differentiation regulation of developmental process regulation of cell differentiation regulation of fat cell differentiation mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process multicellular organismal process inner cell mass cell proliferation cell population proliferation developmental growth chordate embryonic development growth embryo development in utero embryonic development multicellular organism development embryo development ending in birth or egg hatching anatomical structure development blastocyst growth blastocyst development protein-DNA complex remodeling DNA-templated transcription open complex formation protein-containing complex remodeling	cellular anatomical structure intracellular anatomical structure perinuclear region of cytoplasm cytoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen cellular anatomical structure intracellular anatomical structure perinuclear region of cytoplasm cytoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen
H [auth I], W [auth i]	Transcription initiation factor TFIID subunit 9	p53 binding protein binding binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding protein heterodimerization activity protein dimerization activity transcription coactivator activity transcription regulator activity p53 binding protein binding binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding protein heterodimerization activity protein dimerization activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity C2H2 zinc finger domain binding protein domain specific binding transcription factor binding DNA-binding transcription factor binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity ATPase binding enzyme binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly metabolic process macromolecule metabolic process regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death response to peptide response to chemical response to cytokine response to interleukin-1 positive regulation of biological process positive regulation of response to cytokine stimulus positive regulation of response to stimulus regulation of response to cytokine stimulus regulation of response to stimulus catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process negative regulation of protein catabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of ubiquitin-dependent protein catabolic process negative regulation of catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein metabolic process negative regulation of metabolic process proteasomal protein catabolic process protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process regulation of protein catabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of cellular response to stress regulation of signal transduction regulation of intrinsic apoptotic signaling pathway in response to DNA damage intracellular signal transduction regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator cell communication negative regulation of apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage signal transduction intrinsic apoptotic signaling pathway negative regulation of signal transduction by p53 class mediator negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of intrinsic apoptotic signaling pathway negative regulation of cell communication intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of intracellular signal transduction regulation of response to stress regulation of signal transduction by p53 class mediator regulation of signaling negative regulation of response to stimulus signal transduction by p53 class mediator negative regulation of signal transduction apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of cell communication regulation of intrinsic apoptotic signaling pathway by p53 class mediator ribonucleoprotein complex biogenesis small nucleolar ribonucleoprotein complex assembly protein-RNA complex assembly protein-RNA complex organization box C/D snoRNP assembly mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process response to acid chemical response to oxygen-containing compound response to nitrogen compound response to L-glutamate response to amino acid DNA repair DNA metabolic process regulation of DNA repair regulation of DNA metabolic process RNA processing RNA splicing regulation of RNA splicing chromatin organization chromatin remodeling	RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen ribonucleoprotein complex pre-snoRNP complex peptidase complex intracellular membraneless organelle chromatin chromosome histone acetyltransferase complex acetyltransferase complex membraneless organelle protein acetyltransferase complex SAGA-type complex SAGA complex transcription factor TFTC complex histone methyltransferase complex MLL1/2 complex MLL1 complex methyltransferase complex
I [auth J], X [auth j]	Transcription initiation factor TFIID subunit 10	RNA polymerase binding protein binding binding enzyme binding chromatin binding promoter-specific chromatin binding DNA binding nucleic acid binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding RNA polymerase binding protein binding binding enzyme binding chromatin binding promoter-specific chromatin binding DNA binding nucleic acid binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear estrogen receptor binding identical protein binding	transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process developmental process extraembryonic membrane development allantois development anatomical structure development somitogenesis multicellular organismal process epithelium development chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process embryo development tissue development regionalization multicellular organism development anatomical structure morphogenesis embryo development ending in birth or egg hatching somite development anatomical structure formation involved in morphogenesis apoptotic process cell death programmed cell death placenta development animal organ development in utero embryonic development embryonic placenta development embryonic organ development mesodermal cell differentiation cellular developmental process mesoderm morphogenesis lateral mesoderm development lateral mesoderm morphogenesis mesenchyme development cell differentiation lateral mesoderm formation animal organ morphogenesis mesoderm formation mesoderm development formation of primary germ layer mesenchyme morphogenesis embryonic morphogenesis lateral mesodermal cell differentiation gastrulation tissue morphogenesis regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process limb development appendage development SAGA complex assembly gland development liver development epithelial cell differentiation hepaticobiliary system development hepatocyte differentiation system development mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process multicellular organism growth developmental growth growth cellular response to stimulus response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process RNA processing RNA splicing regulation of RNA splicing chromatin organization chromatin remodeling	transcription preinitiation complex protein-containing complex protein-DNA complex RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle transcription preinitiation complex protein-containing complex protein-DNA complex RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen cytoplasm peptidase complex intracellular membraneless organelle chromatin chromosome histone acetyltransferase complex acetyltransferase complex membraneless organelle protein acetyltransferase complex SAGA-type complex SAGA complex transcription factor TFTC complex perinuclear region of cytoplasm male germ cell nucleus germ cell nucleus
J [auth L], Z [auth l]	Transcription initiation factor TFIID subunit 12	protein heterodimerization activity protein binding binding protein dimerization activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding nucleic acid binding transcription factor binding TBP-class protein binding general transcription initiation factor binding protein heterodimerization activity protein binding binding protein dimerization activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding nucleic acid binding transcription factor binding TBP-class protein binding general transcription initiation factor binding DNA-binding transcription factor binding	transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process cellular response to stimulus response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process RNA processing RNA splicing regulation of RNA splicing	RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen peptidase complex intracellular membraneless organelle chromatin chromosome histone acetyltransferase complex acetyltransferase complex membraneless organelle protein acetyltransferase complex SAGA-type complex SAGA complex transcription factor TFTC complex
K [auth O]	Transcription initiation factor IIA subunit 2	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity transcription factor binding TBP-class protein binding general transcription initiation factor binding protein heterodimerization activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity basal transcription machinery binding basal RNA polymerase II transcription machinery binding RNA polymerase II general transcription initiation factor binding	regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression positive regulation of transcription by RNA polymerase II macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process transcription preinitiation complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization protein-DNA complex assembly RNA polymerase II preinitiation complex assembly	cellular anatomical structure cell junction RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure cell junction RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIIA complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen transcription factor TFIID complex
L [auth P]	TATA-box-binding protein	transcription factor binding basal transcription machinery binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding TFIIB-class transcription factor binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding nucleic acid binding transcription factor binding basal transcription machinery binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding TFIIB-class transcription factor binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding core promoter sequence-specific DNA binding RNA polymerase I core promoter sequence-specific DNA binding RNA polymerase I transcription regulatory region sequence-specific DNA binding RNA polymerase III general transcription initiation factor activity general transcription initiation factor activity DNA-binding transcription factor binding RNA polymerase II general transcription initiation factor activity RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding signaling receptor binding aryl hydrocarbon receptor binding enzyme binding	developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process transcription by RNA polymerase III	RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIIA complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen transcription factor TFIID complex cytoplasm membraneless organelle intracellular membraneless organelle chromatin chromosome pronucleus male pronucleus female pronucleus RNA polymerase transcription factor SL1 complex nucleolus RNA polymerase I transcription regulator complex euchromatin germ cell nucleus female germ cell nucleus male germ cell nucleus
M [auth Q]	Transcription initiation factor IIA subunit 1	DNA binding binding nucleic acid binding transcription factor binding protein binding TBP-class protein binding general transcription initiation factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding protein heterodimerization activity protein dimerization activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity sequence-specific DNA binding DNA binding binding nucleic acid binding transcription factor binding protein binding TBP-class protein binding general transcription initiation factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding protein heterodimerization activity protein dimerization activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity sequence-specific DNA binding double-stranded DNA binding core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding basal transcription machinery binding basal RNA polymerase II transcription machinery binding RNA polymerase II general transcription initiation factor binding	regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression positive regulation of transcription by RNA polymerase II macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process transcription preinitiation complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization protein-DNA complex assembly RNA polymerase II preinitiation complex assembly	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIIA complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen transcription preinitiation complex protein-DNA complex transcription factor TFIID complex
N [auth R]	Transcription initiation factor IIB	protein-lysine-acetyltransferase activity catalytic activity, acting on a protein protein N-acetyltransferase activity N-acetyltransferase activity acyltransferase activity histone H3 acetyltransferase activity transferase activity histone acetyltransferase activity acetyltransferase activity histone H3K56 acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity protein-lysine-acetyltransferase activity catalytic activity, acting on a protein protein N-acetyltransferase activity N-acetyltransferase activity acyltransferase activity histone H3 acetyltransferase activity transferase activity histone acetyltransferase activity acetyltransferase activity histone H3K56 acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity histone H3K122 acetyltransferase activity histone H3K9 acetyltransferase activity chromatin binding binding promoter-specific chromatin binding transcription factor binding protein binding TBP-class protein binding general transcription initiation factor binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity histone H3K27 acetyltransferase activity DNA binding sequence-specific DNA binding double-stranded DNA binding core promoter sequence-specific DNA binding nucleic acid binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding histone H4K12 acetyltransferase activity histone H4 acetyltransferase activity RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding nuclear thyroid hormone receptor binding DNA-binding transcription factor binding histone H4K8 acetyltransferase activity histone H3K4 acetyltransferase activity histone H3K14 acetyltransferase activity histone H3K18 acetyltransferase activity histone H2B acetyltransferase activity histone H2BK12 acetyltransferase activity basal transcription machinery binding RNA polymerase binding RNA polymerase II complex binding basal RNA polymerase II transcription machinery binding RNA polymerase core enzyme binding enzyme binding histone H2AK9 acetyltransferase activity histone H2A acetyltransferase activity histone H2AK5 acetyltransferase activity histone H4K5 acetyltransferase activity histone H2BK5 acetyltransferase activity histone H4K16 acetyltransferase activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding histone H3K36 acetyltransferase activity histone H3K23 acetyltransferase activity	transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly cellular process metabolic process macromolecule metabolic process RNA polymerase II core complex assembly organelle assembly microtubule cytoskeleton organization membraneless organelle assembly spindle assembly organelle organization microtubule-based process cell cycle cytoskeleton organization chromosome segregation spindle organization cell cycle process chromosome organization sister chromatid cohesion meiotic sister chromatid cohesion viral gene expression viral process viral transcription protein acetylation macromolecule modification protein metabolic process protein modification process protein acylation DNA-templated transcriptional start site selection transcriptional start site selection at RNA polymerase II promoter regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding positive regulation of transcription regulatory region DNA binding regulation of transcription regulatory region DNA binding biological regulation positive regulation of core promoter binding positive regulation of binding positive regulation of DNA binding	RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen membraneless organelle intracellular membraneless organelle chromosome germinal vesicle germ cell nucleus female germ cell nucleus cell division site transcription preinitiation complex protein-DNA complex chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome nuclear body
O [auth S]	General transcription factor IIF subunit 1	protein binding binding protein domain specific binding transcription factor binding basal transcription machinery binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding RNA binding nucleic acid binding chromatin binding promoter-specific chromatin binding protein phosphatase binding phosphatase binding protein binding binding protein domain specific binding transcription factor binding basal transcription machinery binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding RNA binding nucleic acid binding chromatin binding promoter-specific chromatin binding protein phosphatase binding phosphatase binding enzyme binding DNA binding general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity phosphoric ester hydrolase activity enzyme regulator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity phosphatase activity hydrolase activity enzyme activator activity hydrolase activity, acting on ester bonds molecular function regulator activity catalytic activity TFIIF-class transcription factor complex binding protein-containing complex binding	regulation of protein binding regulation of molecular function negative regulation of protein binding regulation of binding negative regulation of binding biological regulation negative regulation of molecular function RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process regulation of protein binding regulation of molecular function negative regulation of protein binding regulation of binding negative regulation of binding biological regulation negative regulation of molecular function RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process DNA-templated transcription initiation transcription initiation at RNA polymerase II promoter biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus transcription elongation by RNA polymerase II DNA-templated transcription elongation regulation of cellular process positive regulation of DNA-templated transcription positive regulation of transcription elongation by RNA polymerase II positive regulation of biological process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of DNA-templated transcription, elongation positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of DNA-templated transcription elongation regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of transcription elongation by RNA polymerase II regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure cell junction RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure cell junction RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex intracellular membrane-bounded organelle transcription factor TFIIF complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen transcription factor TFIID complex
P [auth T]	General transcription factor IIF subunit 2	DNA binding binding nucleic acid binding nucleic acid conformation isomerase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid single-stranded DNA helicase activity helicase activity 3'-5' DNA helicase activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA single-stranded 3'-5' DNA helicase activity DNA binding binding nucleic acid binding nucleic acid conformation isomerase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid single-stranded DNA helicase activity helicase activity 3'-5' DNA helicase activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA single-stranded 3'-5' DNA helicase activity catalytic activity macromolecular conformation isomerase activity four-way junction helicase activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity forked DNA-dependent helicase activity double-stranded DNA helicase activity	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process transcription initiation at RNA polymerase II promoter transcription elongation by RNA polymerase II DNA-templated transcription elongation regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm catalytic complex intracellular membrane-bounded organelle transcription factor TFIIF complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton
Q [auth X]	DNA (84-mer)	-	-	-
R [auth Y]	DNA (84-mer)	-	-	-
S [auth c]	Transcription initiation factor TFIID subunit 3	p53 binding protein binding binding molecular function inhibitor activity transcription regulator activity molecular function regulator activity transcription regulator inhibitor activity protein heterodimerization activity protein dimerization activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity cation binding ion binding metal ion binding p53 binding protein binding binding molecular function inhibitor activity transcription regulator activity molecular function regulator activity transcription regulator inhibitor activity protein heterodimerization activity protein dimerization activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity cation binding ion binding metal ion binding small molecule binding	regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression positive regulation of transcription by RNA polymerase II macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process negative regulation of DNA-binding transcription factor activity negative regulation of molecular function regulation of molecular function regulation of DNA-binding transcription factor activity transcription preinitiation complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization protein-DNA complex assembly RNA polymerase II preinitiation complex assembly maintenance of protein location protein localization cellular localization maintenance of protein location in nucleus protein localization to nucleus maintenance of location maintenance of location in cell localization maintenance of protein location in cell cellular macromolecule localization macromolecule localization protein localization to organelle maintenance of protein localization in organelle mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process negative regulation of biological process negative regulation of RNA biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process	membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope organelle membrane RNA polymerase II transcription regulator complex membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope organelle membrane RNA polymerase II transcription regulator complex RNA polymerase II, holoenzyme protein-containing complex membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen male germ cell nucleus germ cell nucleus
Y [auth k]	Transcription initiation factor TFIID subunit 11	DNA binding binding nucleic acid binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding DNA-binding transcription factor binding nuclear vitamin D receptor binding TBP-class protein binding general transcription initiation factor binding nuclear thyroid hormone receptor binding protein heterodimerization activity protein dimerization activity DNA binding binding nucleic acid binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding DNA-binding transcription factor binding nuclear vitamin D receptor binding TBP-class protein binding general transcription initiation factor binding nuclear thyroid hormone receptor binding protein heterodimerization activity protein dimerization activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity	regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression positive regulation of transcription by RNA polymerase II macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process transcription preinitiation complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization protein-DNA complex assembly RNA polymerase II preinitiation complex assembly viral gene expression biological process involved in interspecies interaction between organisms viral process modulation of process of another organism viral transcription positive regulation by host of viral transcription host-mediated perturbation of symbiont process mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system RNA polymerase II transcription regulator complex RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system RNA polymerase II transcription regulator complex RNA polymerase II, holoenzyme protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex transferase complex intracellular organelle lumen nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen
AA [auth m]	Transcription initiation factor TFIID subunit 13	DNA binding binding nucleic acid binding transcription factor binding protein binding TBP-class protein binding general transcription initiation factor binding protein heterodimerization activity protein dimerization activity general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity	regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription initiation by RNA polymerase II biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression positive regulation of transcription by RNA polymerase II macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II cellular process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process transcription preinitiation complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization protein-DNA complex assembly RNA polymerase II preinitiation complex assembly mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen RNA polymerase II transcription regulator complex RNA polymerase II, holoenzyme protein-containing complex nuclear protein-containing complex transcription regulator complex transferase complex nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex
BA [auth o]	RPB1	DNA binding binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	-	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
CA [auth p]	DNA-directed RNA polymerase subunit beta	RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups ribonucleoside binding binding nucleoside binding heterocyclic compound binding carbohydrate derivative binding RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups ribonucleoside binding binding nucleoside binding heterocyclic compound binding carbohydrate derivative binding small molecule binding chromatin binding DNA binding nucleic acid binding cation binding ion binding metal ion binding	-	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen membraneless organelle intracellular membraneless organelle chromosome chromosome, telomeric region chromosomal region
DA [auth q]	DNA-directed RNA polymerase II subunit RPB3	DNA binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups protein binding protein dimerization activity	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen cytoplasm cytosol
EA [auth r]	DNA-directed RNA polymerase II subunit RPB4	protein binding binding translation initiation factor binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process transcription initiation at RNA polymerase II promoter	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen RNA polymerase II, holoenzyme protein-containing complex nuclear protein-containing complex transferase complex RNA polymerase II, core complex catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex
GA [auth t]	DNA-directed RNA polymerase II subunit F	DNA binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen fibrillar center RNA polymerase III complex RNA polymerase II, holoenzyme nucleoplasm RNA polymerase II, core complex
HA [auth v]	DNA-directed RNA polymerases I, II, and III subunit RPABC3	DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen
IA [auth w]	DNA-directed RNA polymerase II subunit RPB9	binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cation binding transition metal ion binding zinc ion binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process transcription initiation at RNA polymerase II promoter transcription elongation by RNA polymerase II maintenance of transcriptional fidelity during transcription elongation DNA-templated transcription elongation maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II cellular response to stimulus response to stimulus transcription-coupled nucleotide-excision repair DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen RNA polymerase II, holoenzyme protein-containing complex nuclear protein-containing complex transferase complex nucleoplasm RNA polymerase II, core complex catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex
JA [auth x]	RPB10	DNA binding binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity DNA binding binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process	transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
KA [auth y]	RNA_pol_L_2 domain-containing protein	DNA binding binding nucleic acid binding protein binding protein dimerization activity	-	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen
LA [auth z]	RPB12	DNA binding binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity DNA binding binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle
MA [auth u]	DNA-directed RNA polymerase II subunit RPB7	binding nucleic acid binding	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
FA [auth s]	DNA-directed RNA polymerase II subunit E	DNA binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process nucleolar large rRNA transcription by RNA polymerase I transcription elongation by RNA polymerase I DNA-templated transcription elongation transcription by RNA polymerase I rRNA transcription rRNA metabolic process tRNA metabolic process tRNA transcription tRNA transcription by RNA polymerase III transcription by RNA polymerase III	membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen RNA polymerase II, holoenzyme nucleoplasm RNA polymerase II, core complex RNA polymerase III complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018359	Bromodomain, conserved site	Conserved Site
A	IPR009067	TAFII-230 TBP-binding	Domain
A	IPR040240	Transcription initiation factor TFIID subunit 1	Family
A	IPR011177	Transcription initiation factor TFIID subunit 1, animal	Family
A	IPR022591	Transcription initiation factor TFIID subunit 1, histone acetyltransferase domain	Domain
A	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
A	IPR001487	Bromodomain	Domain
A	IPR041670	Zinc knuckle	Domain
A	IPR036741	TAFII-230 TBP-binding domain superfamily	Homologous Superfamily
B	IPR016024	Armadillo-type fold	Homologous Superfamily
B	IPR027268	Peptidase M4/M1, CTD superfamily	Homologous Superfamily
B	IPR037813	Transcription initiation factor TFIID subunit 2	Family
B	IPR042097	Aminopeptidase N-like , N-terminal domain superfamliy	Homologous Superfamily
C [auth D], T [auth d]	IPR003894	TAFH/NHR1	Domain
C [auth D], T [auth d]	IPR007900	Transcription initiation factor TFIID component TAF4, C-terminal	Domain
C [auth D], T [auth d]	IPR009072	Histone-fold	Homologous Superfamily
C [auth D], T [auth d]	IPR045144	Transcription initiation factor TFIID component TAF4	Family
C [auth D], T [auth d]	IPR037249	TAFH/NHR1 domain superfamily	Homologous Superfamily
D [auth E], U [auth e]	IPR007582	TFIID subunit TAF5, NTD2 domain	Domain
D [auth E], U [auth e]	IPR019775	WD40 repeat, conserved site	Conserved Site
D [auth E], U [auth e]	IPR006594	LIS1 homology motif	Conserved Site
D [auth E], U [auth e]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
D [auth E], U [auth e]	IPR037264	TFIID subunit TAF5, NTD2 domain superfamily	Homologous Superfamily
D [auth E], U [auth e]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
D [auth E], U [auth e]	IPR001680	WD40 repeat	Repeat
D [auth E], U [auth e]	IPR020472	G-protein beta WD-40 repeat	Repeat
E [auth F], V [auth f]	IPR011442	TAF6, C-terminal HEAT repeat domain	Domain
E [auth F], V [auth f]	IPR016024	Armadillo-type fold	Homologous Superfamily
E [auth F], V [auth f]	IPR009072	Histone-fold	Homologous Superfamily
E [auth F], V [auth f]	IPR037796	Transcription initiation factor TFIID subunit 6	Family
E [auth F], V [auth f]	IPR046344	TAF6, C-terminal HEAT repeat domain superfamily	Homologous Superfamily
E [auth F], V [auth f]	IPR004823	TATA box binding protein associated factor (TAF), histone-like fold domain	Domain
F [auth G]	IPR006751	TAFII55 protein, conserved region	Domain
F [auth G]	IPR037817	Transcription initiation factor TFIID subunit 7	Family
G [auth H]	IPR009072	Histone-fold	Homologous Superfamily
G [auth H]	IPR037818	Transcription initiation factor TFIID subunit 8	Family
G [auth H]	IPR006565	Bromodomain associated domain	Domain
G [auth H]	IPR019473	Transcription factor TFIID, subunit 8, C-terminal	Domain
H [auth I], W [auth i]	IPR051431	Transcription initiation factor TFIID subunit 9	Family
H [auth I], W [auth i]	IPR009072	Histone-fold	Homologous Superfamily
H [auth I], W [auth i]	IPR003162	Transcription initiation factor TAFII31	Family
I [auth J], X [auth j]	IPR003923	Transcription initiation factor TFIID, subunit 10	Family
J [auth L], Z [auth l]	IPR009072	Histone-fold	Homologous Superfamily
J [auth L], Z [auth l]	IPR037794	Transcription initiation factor TFIID subunit 12	Family
J [auth L], Z [auth l]	IPR003228	Transcription initiation factor TFIID subunit 12 domain	Domain
K [auth O]	IPR015871	Transcription initiation factor IIA, gamma subunit, C-terminal	Domain
K [auth O]	IPR015872	Transcription initiation factor IIA, gamma subunit, N-terminal	Domain
K [auth O]	IPR009083	Transcription factor IIA, alpha-helical domain	Homologous Superfamily
K [auth O]	IPR009088	Transcription factor IIA, beta-barrel	Homologous Superfamily
K [auth O]	IPR003194	Transcription initiation factor IIA, gamma subunit	Family
L [auth P]	IPR030491	TATA-box binding protein, conserved site	Conserved Site
L [auth P]	IPR000814	TATA-box binding protein	Family
L [auth P]	IPR012295	TBP domain superfamily	Homologous Superfamily
L [auth P]	IPR033710	TATA-box binding protein, eukaryotic	Family
M [auth Q]	IPR004855	Transcription factor IIA, alpha/beta subunit	Family
M [auth Q]	IPR009088	Transcription factor IIA, beta-barrel	Homologous Superfamily
N [auth R]	IPR000812	Transcription factor TFIIB	Family
N [auth R]	IPR013137	Zinc finger, TFIIB-type	Domain
N [auth R]	IPR023486	Transcription factor TFIIB, conserved site	Conserved Site
N [auth R]	IPR013150	Transcription factor TFIIB, cyclin-like domain	Domain
N [auth R]	IPR036915	Cyclin-like superfamily	Homologous Superfamily
N [auth R]	IPR013763	Cyclin-like domain	Domain
O [auth S]	IPR008851	Transcription initiation factor IIF, alpha subunit	Family
O [auth S]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
O [auth S]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
O [auth S]	IPR011039	Transcription Factor IIF, Rap30/Rap74, interaction	Homologous Superfamily
P [auth T]	IPR003196	Transcription initiation factor IIF, beta subunit	Family
P [auth T]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
P [auth T]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
P [auth T]	IPR040450	TFIIF beta subunit, HTH domain	Domain
P [auth T]	IPR040504	TFIIF, beta subunit, N-terminal	Domain
P [auth T]	IPR011039	Transcription Factor IIF, Rap30/Rap74, interaction	Homologous Superfamily
S [auth c]	IPR009072	Histone-fold	Homologous Superfamily
S [auth c]	IPR001965	Zinc finger, PHD-type	Domain
S [auth c]	IPR006565	Bromodomain associated domain	Domain
S [auth c]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
S [auth c]	IPR019787	Zinc finger, PHD-finger	Domain
S [auth c]	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
S [auth c]	IPR019786	Zinc finger, PHD-type, conserved site	Conserved Site
Y [auth k]	IPR009072	Histone-fold	Homologous Superfamily
Y [auth k]	IPR045127	Transcription initiation factor TFIID subunit 11-like	Family
Y [auth k]	IPR006809	TAFII28-like protein domain	Domain
AA [auth m]	IPR009072	Histone-fold	Homologous Superfamily
AA [auth m]	IPR003195	Transcription initiation factor IID, subunit 13	Family
BA [auth o]	IPR007081	RNA polymerase Rpb1, domain 5	Domain
BA [auth o]	IPR045867	DNA-directed RNA polymerase, subunit beta-prime	Family
BA [auth o]	IPR007075	RNA polymerase Rpb1, domain 6	Domain
BA [auth o]	IPR000684	RNA polymerase II, heptapeptide repeat, eukaryotic	Repeat
BA [auth o]	IPR007083	RNA polymerase Rpb1, domain 4	Domain
BA [auth o]	IPR044893	RNA polymerase Rpb1, clamp domain superfamily	Homologous Superfamily
BA [auth o]	IPR006592	RNA polymerase, N-terminal	Domain
BA [auth o]	IPR007066	RNA polymerase Rpb1, domain 3	Domain
BA [auth o]	IPR007073	RNA polymerase Rpb1, domain 7	Domain
BA [auth o]	IPR042102	RNA polymerase Rpb1, domain 3 superfamily	Homologous Superfamily
BA [auth o]	IPR038593	RNA polymerase Rpb1, domain 7 superfamily	Homologous Superfamily
BA [auth o]	IPR000722	RNA polymerase, alpha subunit	Domain
BA [auth o]	IPR038120	RNA polymerase Rpb1, funnel domain superfamily	Homologous Superfamily
BA [auth o]	IPR007080	RNA polymerase Rpb1, domain 1	Domain
CA [auth p]	IPR007120	DNA-directed RNA polymerase, subunit 2, hybrid-binding domain	Domain
CA [auth p]	IPR007121	RNA polymerase, beta subunit, conserved site	Conserved Site
CA [auth p]	IPR007646	RNA polymerase Rpb2, domain 4	Domain
CA [auth p]	IPR007647	RNA polymerase Rpb2, domain 5	Domain
CA [auth p]	IPR014724	RNA polymerase Rpb2, OB-fold	Homologous Superfamily
CA [auth p]	IPR007642	RNA polymerase Rpb2, domain 2	Domain
CA [auth p]	IPR015712	DNA-directed RNA polymerase, subunit 2	Family
CA [auth p]	IPR037033	DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily	Homologous Superfamily
CA [auth p]	IPR037034	RNA polymerase Rpb2, domain 2 superfamily	Homologous Superfamily
CA [auth p]	IPR007645	RNA polymerase Rpb2, domain 3	Domain
CA [auth p]	IPR007644	RNA polymerase, beta subunit, protrusion	Domain
CA [auth p]	IPR007641	RNA polymerase Rpb2, domain 7	Domain
DA [auth q]	IPR011262	DNA-directed RNA polymerase, insert domain	Domain
DA [auth q]	IPR011263	DNA-directed RNA polymerase, RpoA/D/Rpb3-type	Domain
DA [auth q]	IPR050518	Archaeal Rpo3/Eukaryotic RPB3 RNA Polymerase Subunit	Family
DA [auth q]	IPR022842	DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1	Family
DA [auth q]	IPR036643	DNA-directed RNA polymerase, insert domain superfamily	Homologous Superfamily
DA [auth q]	IPR001514	DNA-directed RNA polymerase, 30-40kDa subunit, conserved site	Conserved Site
DA [auth q]	IPR036603	RNA polymerase, RBP11-like subunit	Homologous Superfamily
EA [auth r]	IPR005574	RNA polymerase subunit Rpb4/RPC9	Family
EA [auth r]	IPR010997	HRDC-like superfamily	Homologous Superfamily
EA [auth r]	IPR006590	RNA polymerase Rpb4/RPC9, core	Domain
EA [auth r]	IPR038324	Rpb4/RPC9 superfamily	Homologous Superfamily
EA [auth r]	IPR045222	DNA-directed RNA polymerase II subunit Rpb4-like	Family
GA [auth t]	IPR020708	DNA-directed RNA polymerase, 14-18kDa subunit, conserved site	Conserved Site
GA [auth t]	IPR036161	RPB6/omega subunit-like superfamily	Homologous Superfamily
GA [auth t]	IPR028363	DNA-directed RNA polymerase, subunit RPB6	Family
GA [auth t]	IPR006110	RNA polymerase, subunit omega/Rpo6/RPB6	Family
GA [auth t]	IPR006111	Archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit	Family
HA [auth v]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
HA [auth v]	IPR005570	DNA-directed RNA polymerases I, II, and III subunit RPABC3	Family
IA [auth w]	IPR001529	DNA-directed RNA polymerase II subunit RPB9-like, zinc ribbon	Domain
IA [auth w]	IPR012164	DNA-directed RNA polymerase subunit/transcription factor S	Family
IA [auth w]	IPR001222	Zinc finger, TFIIS-type	Domain
IA [auth w]	IPR034012	Pol II subunit B9, C-terminal zinc ribbon	Domain
IA [auth w]	IPR019761	DNA-directed RNA polymerase M, 15kDa subunit, conserved site	Conserved Site
JA [auth x]	IPR023580	RNA polymerase subunit RPB10	Homologous Superfamily
JA [auth x]	IPR020789	RNA polymerases, subunit N, zinc binding site	Binding Site
JA [auth x]	IPR000268	DNA-directed RNA polymerase subunit RPABC5/Rpb10	Family
KA [auth y]	IPR022905	DNA-directed RNA polymerase subunit Rpo11-like	Family
KA [auth y]	IPR009025	DNA-directed RNA polymerase, RBP11-like dimerisation domain	Domain
KA [auth y]	IPR036603	RNA polymerase, RBP11-like subunit	Homologous Superfamily
KA [auth y]	IPR008193	DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site	Conserved Site
KA [auth y]	IPR037685	RNA polymerase RBP11	Family
LA [auth z]	IPR006591	RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4	Family
LA [auth z]	IPR029040	RNA polymerase subunit RPABC4/transcription elongation factor Spt4	Homologous Superfamily
LA [auth z]	IPR039747	DNA-directed RNA polymerases I, II, and III subunit RPABC4	Family
MA [auth u]	IPR036898	RNA polymerase Rpb7-like, N-terminal domain superfamily	Homologous Superfamily
MA [auth u]	IPR003029	S1 domain	Domain
MA [auth u]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
MA [auth u]	IPR045113	RNA polymerase subunit Rpb7-like	Family
MA [auth u]	IPR005576	RNA polymerase Rpb7-like , N-terminal	Domain
FA [auth s]	IPR014381	DNA-directed RNA polymerase subunit Rpo5/Rpb5	Family
FA [auth s]	IPR036710	RNA polymerase Rpb5, N-terminal domain superfamily	Homologous Superfamily
FA [auth s]	IPR035913	RPB5-like RNA polymerase subunit superfamily	Homologous Superfamily
FA [auth s]	IPR000783	RNA polymerase, subunit H/Rpb5 C-terminal	Domain
FA [auth s]	IPR020608	RNA polymerase, subunit H/Rpb5, conserved site	Conserved Site
FA [auth s]	IPR005571	RNA polymerase, Rpb5, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P21675	X-linked dystonia-parkinsonism dystonic disorder intellectual disability, X-linked, syndromic 33 intellectual disability Parkinson disease colorectal adenocarcinoma medulloblastoma metastatic melanoma rheumatoid arthritis generalized dystonia juvenile dermatomyositis osteosarcoma
B	Pharos: Q6P1X5	intellectual disability microcephaly-thin corpus callosum-intellectual disability syndrome autosomal recessive non-syndromic intellectual disability large cell medulloblastoma Mental Retardation, Psychosocial osteosarcoma idiopathic pulmonary fibrosis lung cancer microcephaly ovarian cancer primitive neuroectodermal tumor
C [auth D], T [auth d]	Pharos: O00268	lung cancer subependymal giant cell astrocytoma malignant glioma malignant mesothelioma
D [auth E], U [auth e]	Pharos: Q15542	anorexia nervosa malignant mesothelioma subependymal giant cell astrocytoma attention deficit hyperactivity disorder, inattentive type medulloblastoma ulcerative colitis lung cancer osteosarcoma
E [auth F], V [auth f]	Pharos: P49848	Alazami-Yuan syndrome intellectual disability idiopathic pulmonary fibrosis chronic obstructive pulmonary disease Cornelia de Lange syndrome 1 ovarian cancer
F [auth G]	Pharos: Q15545	lymphoplasmacytic lymphoma ovarian cancer plasma cell myeloma
G [auth H]	Pharos: Q7Z7C8	inflammatory bowel disease malignant ependymoma osteosarcoma
H [auth I], W [auth i]	Pharos: Q16594	HIV infectious disease astrocytic tumor IgA glomerulonephritis oligodendroglioma HIV Coinfection lung cancer Pick disease myopathy plasma cell myeloma
I [auth J], X [auth j]	Pharos: Q12962	Gaucher disease pancreatic intraductal papillary-mucinous neoplasm osteosarcoma ovarian cancer
J [auth L], Z [auth l]	Pharos: Q16514	lung adenocarcinoma
K [auth O]	Pharos: P52657	oligodendroglioma ovarian cancer plasma cell myeloma
L [auth P]	Pharos: P20226	spinocerebellar ataxia type 17 autosomal dominant cerebellar ataxia late-onset Parkinson disease Parkinson disease acute myeloid leukemia hereditary ataxia malignant mesothelioma osteosarcoma psoriasis Ataxias, Hereditary intellectual disability medulloblastoma ovarian cancer schizophrenia neurodegenerative disease
M [auth Q]	Pharos: P52655	acute myeloid leukemia ovarian cancer Malignant neoplasm of breast pancreatic ductal adenocarcinoma myopathy psoriasis
N [auth R]	Pharos: Q00403	colorectal cancer lung cancer pancreatic intraductal papillary-mucinous neoplasm dermatomyositis osteosarcoma plasma cell myeloma diabetes mellitus ovarian cancer
P [auth T]	Pharos: P13984	lung cancer osteosarcoma psoriasis
S [auth c]	Pharos: Q5VWG9	acute lymphoblastic leukemia B-cell acute lymphoblastic leukemia malignant glioma osteosarcoma Alzheimer disease colorectal cancer medulloblastoma rheumatoid arthritis asthma Hodgkins lymphoma nodular sclerosis classical Hodgkin lymphoma
Y [auth k]	Pharos: Q15544	breast cancer lymphoplasmacytic lymphoma ovarian cancer heart disease medulloblastoma prostate carcinoma juvenile dermatomyositis osteosarcoma systemic lupus erythematosus
AA [auth m]	Pharos: Q15543	intellectual disability, autosomal recessive 60 autosomal recessive primary microcephaly cystic fibrosis MENTAL RETARDATION, AUTOSOMAL RECESSIVE 60 pituitary cancer breast cancer intellectual disability osteosarcoma Crohn disease pancreatic ductal adenocarcinoma