7QSR | pdb_00007qsr

CryoEM structure of the Ectodomain of Human PLA2R

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	C-type lectin-like	8099158	3001261	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ricin_B_lectin	e7qsrA9	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Ricin_B_lectin	ECOD (1.6)
A	Lectin_C	e7qsrA10	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
A	fn2	e7qsrA5	A: few secondary structure elements	X: Kringle-like (From Topology)	H: Kringle-like (From Topology)	T: Kringle-like	F: fn2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00040	Fibronectin type II domain (fn2)	Fibronectin type II domain		Domain
A	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Secretory phospholipase A2 receptor	phospholipase binding protein binding binding enzyme binding molecular transducer activity signaling receptor activity carbohydrate binding	reactive oxygen species metabolic process metabolic process cellular process cellular response to stimulus response to stimulus cellular response to oxidative stress cellular senescence cellular response to chemical stress oxidative stress-induced premature senescence response to oxidative stress cellular response to chemical stimulus stress-induced premature senescence cellular response to stress response to stress reactive oxygen species metabolic process metabolic process cellular process cellular response to stimulus response to stimulus cellular response to oxidative stress cellular senescence cellular response to chemical stress oxidative stress-induced premature senescence response to oxidative stress cellular response to chemical stimulus stress-induced premature senescence cellular response to stress response to stress response to chemical replicative senescence cell cycle cell cycle process regulation of localization positive regulation of arachidonate secretion transport positive regulation of biological process regulation of lipid transport regulation of arachidonate secretion localization arachidonate secretion monocarboxylic acid transport positive regulation of secretion fatty acid transport icosanoid transport regulation of icosanoid secretion icosanoid secretion long-chain fatty acid transport positive regulation of icosanoid secretion regulation of biological process organic anion transport carboxylic acid transport secretion arachidonate transport regulation of transport biological regulation lipid localization lipid transport positive regulation of lipid localization establishment of localization regulation of fatty acid transport regulation of secretion positive regulation of organic acid transport organic acid transport positive regulation of lipid transport positive regulation of transport regulation of lipid localization macromolecule localization regulation of organic acid transport positive regulation of fatty acid transport regulation of phospholipase activity negative regulation of hydrolase activity regulation of catalytic activity negative regulation of lipase activity negative regulation of molecular function negative regulation of catalytic activity negative regulation of phospholipase A2 activity regulation of phospholipase A2 activity negative regulation of phospholipase activity regulation of molecular function regulation of hydrolase activity positive regulation of epithelial cell apoptotic process positive regulation of programmed cell death regulation of cellular process regulation of epithelial cell apoptotic process regulation of apoptotic process regulation of programmed cell death podocyte apoptotic process regulation of podocyte apoptotic process cell death positive regulation of apoptotic process epithelial cell apoptotic process positive regulation of podocyte apoptotic process apoptotic process programmed cell death positive regulation of cellular process positive regulation of cell communication positive regulation of signal transduction signaling regulation of cellular response to stress regulation of signal transduction DNA damage response, signal transduction by p53 class mediator intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction regulation of response to stress regulation of signal transduction by p53 class mediator positive regulation of signal transduction by p53 class mediator signal transduction regulation of DNA damage response, signal transduction by p53 class mediator regulation of signaling positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of intracellular signal transduction signal transduction by p53 class mediator regulation of response to stimulus DNA damage response regulation of cell communication signal transduction in response to DNA damage positive regulation of signaling multicellular organismal process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process regulation of multicellular organismal process regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process negative regulation of biological process negative regulation of transport negative regulation of lipid localization negative regulation of icosanoid secretion negative regulation of secretion negative regulation of arachidonate secretion negative regulation of lipid transport negative regulation of fatty acid transport negative regulation of organic acid transport import into cell receptor-mediated endocytosis endocytosis vesicle-mediated transport	cell surface cellular anatomical structure cell periphery plasma membrane membrane protein-containing complex receptor complex extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036943	Fibronectin type II domain superfamily	Homologous Superfamily
A	IPR016187	C-type lectin fold	Homologous Superfamily
A	IPR001304	C-type lectin-like	Domain
A	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A	IPR035992	Ricin B-like lectins	Homologous Superfamily
A	IPR000562	Fibronectin type II domain	Domain
A	IPR018378	C-type lectin, conserved site	Conserved Site
A	IPR050111	C-type lectin and snaclec domain-containing protein	Family
A	IPR000772	Ricin B, lectin domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q13018	substance abuse Substance Use Disorders breast cancer drug dependence inflammatory bowel disease malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma proteinuria substance-related disorder breast carcinoma invasive ductal breast carcinoma membranous glomerulonephritis osteosarcoma pituitary cancer psoriasis substance abuse Substance Use Disorders breast cancer drug dependence inflammatory bowel disease malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma proteinuria substance-related disorder breast carcinoma invasive ductal breast carcinoma membranous glomerulonephritis osteosarcoma pituitary cancer psoriasis substance dependence lung carcinoma nephritis ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.