7RGG | pdb_00007rgg

Room temperature serial crystal structure of Glutaminase C in complex with inhibitor BPTES

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	beta-lactamase/transpeptidase-like	8064348	3001604	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	beta-lactamase/transpeptidase-like	8064348	3001604	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	beta-lactamase/transpeptidase-like	8064348	3001604	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	beta-lactamase/transpeptidase-like	8064348	3001604	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KOG0506	e7rggA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: KOG0506	ECOD (1.6)
A	Glutaminase_2nd	e7rggA2	A: alpha complex topology	X: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)	H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)	T: alpha-helical domain in beta-lactamase/transpeptidase-like proteins	F: Glutaminase_2nd	ECOD (1.6)
A	Glutaminase_1st	e7rggA3	A: a+b three layers	X: Profilin-like	H: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)	T: a+b domain in beta-lactamase/transpeptidase-like proteins	F: Glutaminase_1st	ECOD (1.6)
B	KOG0506	e7rggB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: KOG0506	ECOD (1.6)
B	Glutaminase_2nd	e7rggB3	A: alpha complex topology	X: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)	H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)	T: alpha-helical domain in beta-lactamase/transpeptidase-like proteins	F: Glutaminase_2nd	ECOD (1.6)
B	Glutaminase_1st	e7rggB2	A: a+b three layers	X: Profilin-like	H: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)	T: a+b domain in beta-lactamase/transpeptidase-like proteins	F: Glutaminase_1st	ECOD (1.6)
C	KOG0506	e7rggC2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: KOG0506	ECOD (1.6)
C	Glutaminase_2nd	e7rggC3	A: alpha complex topology	X: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)	H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)	T: alpha-helical domain in beta-lactamase/transpeptidase-like proteins	F: Glutaminase_2nd	ECOD (1.6)
C	Glutaminase_1st	e7rggC1	A: a+b three layers	X: Profilin-like	H: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)	T: a+b domain in beta-lactamase/transpeptidase-like proteins	F: Glutaminase_1st	ECOD (1.6)
D	KOG0506	e7rggD1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: KOG0506	ECOD (1.6)
D	Glutaminase_2nd	e7rggD3	A: alpha complex topology	X: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)	H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)	T: alpha-helical domain in beta-lactamase/transpeptidase-like proteins	F: Glutaminase_2nd	ECOD (1.6)
D	Glutaminase_1st	e7rggD2	A: a+b three layers	X: Profilin-like	H: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)	T: a+b domain in beta-lactamase/transpeptidase-like proteins	F: Glutaminase_1st	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF17959	EF-hand domain (EF-hand_14)	EF-hand domain	This EF-hand domain is found at the N-terminus of the human glutaminase enzyme [1].	Domain
A, B, C, D	PF04960	Glutaminase (Glutaminase)	Glutaminase	This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Glutaminase kidney isoform, mitochondrial 68 kDa chain	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides glutaminase activity hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	intracellular amino acid homeostasis cellular homeostasis intracellular glutamate homeostasis chemical homeostasis homeostatic process intracellular chemical homeostasis behavior suckling behavior multicellular organismal process feeding behavior trans-synaptic signaling synaptic signaling regulation of biological process signaling intracellular amino acid homeostasis cellular homeostasis intracellular glutamate homeostasis chemical homeostasis homeostatic process intracellular chemical homeostasis behavior suckling behavior multicellular organismal process feeding behavior trans-synaptic signaling synaptic signaling regulation of biological process signaling anterograde trans-synaptic signaling biological regulation cell-cell signaling cellular process chemical synaptic transmission cell communication protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis system process nervous system process regulation of system process respiratory gaseous exchange by respiratory system respiratory system process regulation of respiratory gaseous exchange regulation of multicellular organismal process regulation of respiratory system process regulation of respiratory gaseous exchange by nervous system process catabolic process oxoacid metabolic process glutamine family amino acid catabolic process amino acid metabolic process organic acid metabolic process organic acid catabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process carboxylic acid catabolic process small molecule metabolic process amino acid catabolic process glutamine metabolic process glutamine catabolic process carboxylic acid metabolic process L-amino acid catabolic process primary metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process alpha-amino acid catabolic process proteinogenic amino acid catabolic process metabolic process small molecule catabolic process glutamine family amino acid biosynthetic process organic acid biosynthetic process carboxylic acid biosynthetic process glutamate metabolic process dicarboxylic acid biosynthetic process small molecule biosynthetic process dicarboxylic acid metabolic process L-amino acid biosynthetic process amino acid biosynthetic process biosynthetic process proteinogenic amino acid biosynthetic process glutamate biosynthetic process alpha-amino acid biosynthetic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle synapse cell junction cytosol membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle synapse cell junction cytosol membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR002110	Ankyrin repeat	Repeat
A, B, C, D	IPR012338	Beta-lactamase/transpeptidase-like	Homologous Superfamily
A, B, C, D	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B, C, D	IPR015868	Glutaminase	Family
A, B, C, D	IPR041541	Glutaminase, EF-hand domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: O94925	Liver Cirrhosis, Experimental interstitial cystitis malignant ependymoma medulloblastoma non-small cell lung carcinoma adenoma osteoarthritis susceptibility 1 atopic eczema ovarian cancer celiac disease pituitary cancer cutaneous lupus erythematosus psoriasis epilepsy subependymal giant cell astrocytoma Liver Cirrhosis, Experimental interstitial cystitis malignant ependymoma medulloblastoma non-small cell lung carcinoma adenoma osteoarthritis susceptibility 1 atopic eczema ovarian cancer celiac disease pituitary cancer cutaneous lupus erythematosus psoriasis epilepsy subependymal giant cell astrocytoma gastric carcinoma tuberculosis juvenile dermatomyositis lung cancer malignant glioma nasopharyngeal carcinoma oligodendroglioma Alzheimer disease atypical teratoid rhabdoid tumor Pick disease congenital disorder of glycosylation primary biliary cholangitis dermatomyositis schizophrenia esophageal adenocarcinoma systemic lupus erythematosus glioblastoma ulcerative colitis large cell medulloblastoma lung carcinoma malignant mesothelioma nephrosclerosis osteoarthritis astrocytic tumor osteosarcoma cataract pilocytic astrocytoma Crohn disease primitive neuroectodermal tumor Emery-Dreifuss muscular dystrophy gastric cancer systemic sclerosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.