7SG1

XPA5 TCR in complex with HLA-DQ2-alpha1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MHC antigen-recognition domain	8041502	3000521	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054679	3000071	SCOP2B (2022-06-29)
C [auth F]	SCOP2B Superfamily	MHC antigen-recognition domain	8041502	3000521	SCOP2B (2022-06-29)
C [auth F]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054679	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C1-set_2	e7sg1A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
A	MHC_II_alpha	e7sg1A2	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_II_alpha	ECOD (1.6)
C [auth F]	C1-set_2	e7sg1F1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
C [auth F]	MHC_II_alpha	e7sg1F2	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_II_alpha	ECOD (1.6)
E [auth D]	DUF1968	e7sg1D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: DUF1968	ECOD (1.6)
E [auth D]	V-set_3	e7sg1D2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
I	DUF1968	e7sg1I2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: DUF1968	ECOD (1.6)
I	V-set_3	e7sg1I1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
F [auth E]	C1-set	e7sg1E1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
F [auth E]	V-set_5	e7sg1E2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_5	ECOD (1.6)
J	C1-set	e7sg1J1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
J	V-set_5	e7sg1J2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_5	ECOD (1.6)
B	C1-set_2	e7sg1B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
B	MHC_II_beta	e7sg1B2	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_II_beta	ECOD (1.6)
D [auth G]	C1-set_2	e7sg1G1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
D [auth G]	MHC_II_beta	e7sg1G2	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_II_beta	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth F]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
A, C [auth F]	PF00993	Class II histocompatibility antigen, alpha domain (MHC_II_alpha)	Class II histocompatibility antigen, alpha domain	-	Domain
B, D [auth G]	PF00969	Class II histocompatibility antigen, beta domain (MHC_II_beta)	Class II histocompatibility antigen, beta domain	-	Domain
B, D [auth G]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth F]	HLA class II histocompatibility antigen, DQ alpha 1 chain	binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity MHC class II receptor activity immune receptor activity	regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process adaptive immune response antigen processing and presentation of exogenous peptide antigen via MHC class II regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process adaptive immune response antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen antigen processing and presentation of exogenous antigen peptide antigen assembly with MHC class II protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class II protein complex assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex assembly cellular process MHC protein complex assembly cellular component organization or biogenesis multicellular organismal process regulation of cellular process regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation positive regulation of leukocyte activation regulation of multicellular organismal process regulation of cell-cell adhesion positive regulation of cellular process positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process regulation of lymphocyte activation	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane MHC protein complex cell periphery MHC class II protein complex protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex endosome membrane endosome late endosome membrane endomembrane system late endosome organelle subcompartment lumenal side of endoplasmic reticulum membrane side of membrane lumenal side of membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi membrane Golgi apparatus Golgi apparatus subcompartment trans-Golgi network membrane trans-Golgi network transport vesicle transport vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane
E [auth D], I	T-cell receptor, xpa5, alpha chain	-	-	-
F [auth E], J	T-cell receptor, xpa5, beta chain	-	-	-
G [auth C], H	DQ2-glia-alpha1a peptide	-	-	-
B, D [auth G]	MHC class II HLA-DQ-beta-1	cation binding ion binding binding metal ion binding small molecule binding	antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune system process response to stimulus immune response adaptive immune response	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome MHC protein complex cell periphery MHC class II protein complex protein-containing complex plasma membrane protein complex plasma membrane membrane protein complex endosome membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth F]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, C [auth F]	IPR050160	Major Histocompatibility Complex/Immunoglobulin	Family
A, C [auth F]	IPR003597	Immunoglobulin C1-set	Domain
A, C [auth F]	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A, C [auth F]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A, C [auth F]	IPR014745	MHC class II, alpha/beta chain, N-terminal	Homologous Superfamily
A, C [auth F]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, C [auth F]	IPR007110	Immunoglobulin-like domain	Domain
A, C [auth F]	IPR001003	MHC class II, alpha chain, N-terminal	Domain
B, D [auth G]	IPR000353	MHC class II, beta chain, N-terminal	Domain
B, D [auth G]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B, D [auth G]	IPR050160	Major Histocompatibility Complex/Immunoglobulin	Family
B, D [auth G]	IPR014745	MHC class II, alpha/beta chain, N-terminal	Homologous Superfamily
B, D [auth G]	IPR003597	Immunoglobulin C1-set	Domain
B, D [auth G]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, D [auth G]	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
B, D [auth G]	IPR007110	Immunoglobulin-like domain	Domain
B, D [auth G]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C [auth F]	Pharos: P01909	membranous glomerulonephritis achalasia type 1 diabetes mellitus oropharynx cancer systemic lupus erythematosus celiac disease eosinophilia-myalgia syndrome visceral leishmaniasis pancreatitis ulcerative colitis asthma juvenile idiopathic arthritis narcolepsy B-cell chronic lymphocytic leukemia lung carcinoma membranous glomerulonephritis achalasia type 1 diabetes mellitus oropharynx cancer systemic lupus erythematosus celiac disease eosinophilia-myalgia syndrome visceral leishmaniasis pancreatitis ulcerative colitis asthma juvenile idiopathic arthritis narcolepsy B-cell chronic lymphocytic leukemia lung carcinoma Sjogren syndrome alopecia areata proteinuria dermatitis megaesophagus allergic disease chronic obstructive pulmonary disease Crohn disease lymphoma squamous cell carcinoma Diabetes Mellitus, Insulin-Dependent systemic sclerosis mycobacterium tuberculosis, susceptibility to tuberculosis neoplasm of mature B-cells Hashimoto thyroiditis neuromyelitis optica allergic rhinitis hepatitis B virus infection oral cavity cancer atopic eczema idiopathic achalasia inflammatory bowel disease primary biliary cholangitis celiac disease, susceptibility to, 1 leprosy rheumatoid arthritis colorectal adenoma cutaneous lupus erythematosus malignant glioma squamous cell lung carcinoma metabolic syndrome X Takayasu arteritis Duchenne muscular dystrophy nasal cavity disease vitiligo glioblastoma neoplasm of oropharynx acquired metabolic disease head and neck cancer non-alcoholic fatty liver disease hepatitis C virus infection autism spectrum disorder idiopathic membranous glomerulonephritis pemphigus vulgaris invasive ductal breast carcinoma cervical cancer rosacea colorectal cancer skin basal cell carcinoma myasthenia gravis temporal arteritis endogenous depression myositis eosinophilic granulomatosis with polyangiitis nasopharyngeal disease Graves disease nephrotic syndrome head and neck squamous cell carcinoma non-small cell lung carcinoma hepatocellular carcinoma hypothyroidism ovarian cancer autoimmune disease IgA glomerulonephritis peripheral arterial disease psoriatic arthritis lung cancer sinusitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.