Annotations: 7T3N

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07690	Major Facilitator Superfamily (MFS_1)	Major Facilitator Superfamily	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Vesicular glutamate transporter 2	monoatomic cation transmembrane transporter activity sodium:phosphate symporter activity solute:sodium symporter activity solute:monoatomic cation symporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity symporter activity monoatomic cation transmembrane transporter activity sodium:phosphate symporter activity solute:sodium symporter activity solute:monoatomic cation symporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity symporter activity inorganic anion transmembrane transporter activity phosphate transmembrane transporter activity L-amino acid transmembrane transporter activity amino acid transmembrane transporter activity acidic amino acid transmembrane transporter activity L-glutamate transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity organic anion transmembrane transporter activity neurotransmitter transmembrane transporter activity L-glutamate uniporter activity uniporter activity membrane potential driven uniporter activity phosphate ion uniporter activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity monoatomic ion channel activity passive transmembrane transporter activity channel activity monoatomic anion channel activity chloride channel activity metal cation:monoatomic cation antiporter activity proton transmembrane transporter activity potassium ion transmembrane transporter activity potassium:proton antiporter activity antiporter activity metal cation:proton antiporter activity solute:potassium antiporter activity	biological regulation regulation of synapse structure or activity regulation of biological quality organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport transport amino acid transmembrane transport L-amino acid transport establishment of localization L-glutamate import organic acid transport biological regulation regulation of synapse structure or activity regulation of biological quality organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport transport amino acid transmembrane transport L-amino acid transport establishment of localization L-glutamate import organic acid transport transmembrane transport amino acid transport localization acidic amino acid transport dicarboxylic acid transport L-alpha-amino acid transmembrane transport cellular process L-glutamate transmembrane transport developmental process multicellular organismal process head development forebrain development animal organ development brain development nervous system development pallium development multicellular organism development central nervous system development anatomical structure development telencephalon development hippocampus development limbic system development system development phosphate ion transport inorganic anion transport sensory organ development eye development visual system development anatomical structure regression anatomical structure morphogenesis hyaloid vascular plexus regression camera-type eye development sensory system development phosphate ion homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process import into cell neurotransmitter uptake neurotransmitter transport monoatomic anion transport monoatomic ion transport sodium-dependent phosphate transport retina development in camera-type eye neural retina development trans-synaptic signaling regulation of biological process signaling synaptic transmission, glutamatergic cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling cellular localization synaptic vesicle cycle vesicle-mediated transport vesicle-mediated transport in synapse neurotransmitter loading into synaptic vesicle establishment of localization in cell	protein-containing complex cellular anatomical structure transmembrane transporter complex membrane chloride channel complex membrane protein complex transporter complex monoatomic ion channel complex cell periphery plasma membrane presynapse synapse cell junction cell projection protein-containing complex cellular anatomical structure transmembrane transporter complex membrane chloride channel complex membrane protein complex transporter complex monoatomic ion channel complex cell periphery plasma membrane presynapse synapse cell junction cell projection neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle excitatory synapse axon pericellular basket transport vesicle membrane bounding membrane of organelle vesicle membrane synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle organelle membrane exocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011701	Major facilitator superfamily	Family
A	IPR020846	Major facilitator superfamily domain	Domain
A	IPR050382	Major Facilitator Superfamily Sodium/Anion Cotransporter	Family
A	IPR036259	MFS transporter superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Alpha-helical polytopic	Major Facilitator Superfamily (MFS)	Glycerol-3-phosphate transporter

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.