7W85

Structural of the filamentous Escherichia coli glutamine synthetase

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Gln-synt_N	e7w85A2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
A	Gln-synt_C	e7w85A1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
B	Gln-synt_N	e7w85B1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
B	Gln-synt_C	e7w85B2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
C	Gln-synt_N	e7w85C2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
C	Gln-synt_C	e7w85C1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
D	Gln-synt_N	e7w85D2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
D	Gln-synt_C	e7w85D1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
E	Gln-synt_N	e7w85E1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
E	Gln-synt_C	e7w85E2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
F	Gln-synt_N	e7w85F1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
F	Gln-synt_C	e7w85F2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
G	Gln-synt_N	e7w85G2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
G	Gln-synt_C	e7w85G1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
H	Gln-synt_N	e7w85H1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
H	Gln-synt_C	e7w85H2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
I	Gln-synt_N	e7w85I1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
I	Gln-synt_C	e7w85I2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
J	Gln-synt_N	e7w85J1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
J	Gln-synt_C	e7w85J2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
K	Gln-synt_N	e7w85K1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
K	Gln-synt_C	e7w85K2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
L	Gln-synt_N	e7w85L1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
L	Gln-synt_C	e7w85L2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
M	Gln-synt_N	e7w85M2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
M	Gln-synt_C	e7w85M1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
N	Gln-synt_N	e7w85N2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
N	Gln-synt_C	e7w85N1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
O	Gln-synt_N	e7w85O2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
O	Gln-synt_C	e7w85O1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
P	Gln-synt_N	e7w85P1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
P	Gln-synt_C	e7w85P2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
Q	Gln-synt_N	e7w85Q1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
Q	Gln-synt_C	e7w85Q2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
R	Gln-synt_N	e7w85R2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
R	Gln-synt_C	e7w85R1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
S	Gln-synt_N	e7w85S1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
S	Gln-synt_C	e7w85S2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
T [auth U]	Gln-synt_N	e7w85U2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
T [auth U]	Gln-synt_C	e7w85U1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
U [auth V]	Gln-synt_N	e7w85V1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
U [auth V]	Gln-synt_C	e7w85V2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
V [auth W]	Gln-synt_N	e7w85W2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
V [auth W]	Gln-synt_C	e7w85W1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
W [auth X]	Gln-synt_N	e7w85X2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
W [auth X]	Gln-synt_C	e7w85X1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
X [auth Y]	Gln-synt_N	e7w85Y1	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
X [auth Y]	Gln-synt_C	e7w85Y2	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	PF00120	Glutamine synthetase, catalytic domain (Gln-synt_C)	Glutamine synthetase, catalytic domain	-	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	PF03951	Glutamine synthetase, beta-Grasp domain (Gln-synt_N)	Glutamine synthetase, beta-Grasp domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	Glutamine synthetase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding acid-ammonia (or amide) ligase activity ammonia ligase activity glutamine synthetase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity cation binding metal ion binding identical protein binding protein binding	response to nutrient levels cellular homeostasis chemical homeostasis response to stimulus homeostatic process intracellular nitrogen homeostasis nitrogen utilization intracellular chemical homeostasis oxoacid metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process glutamate metabolic process response to nutrient levels cellular homeostasis chemical homeostasis response to stimulus homeostatic process intracellular nitrogen homeostasis nitrogen utilization intracellular chemical homeostasis oxoacid metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process glutamate metabolic process small molecule metabolic process glutamine metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process primary metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process ammonia assimilation cycle metabolic process cellular process response to radiation response to abiotic stimulus glutamine family amino acid biosynthetic process organic acid biosynthetic process carboxylic acid biosynthetic process small molecule biosynthetic process L-amino acid biosynthetic process amino acid biosynthetic process biosynthetic process proteinogenic amino acid biosynthetic process glutamine biosynthetic process alpha-amino acid biosynthetic process	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR004809	Glutamine synthetase type I	Family
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR008146	Glutamine synthetase, catalytic domain	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR001637	Glutamine synthetase class-I, adenylation site	Conserved Site
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR027303	Glutamine synthetase, glycine-rich site	Conserved Site
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR027302	Glutamine synthetase, N-terminal conserved site	Conserved Site
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR014746	Glutamine synthetase/guanido kinase, catalytic domain	Homologous Superfamily
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR008147	Glutamine synthetase, N-terminal domain	Domain
A, B, C, D, E, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR036651	Glutamine synthetase, N-terminal domain superfamily	Homologous Superfamily