Annotations: 8AS5

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nucleoplasmin-like core domain	8072507	3002011	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Nucleoplasmin-like core domain	8072507	3002011	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Nucleoplasmin-like core domain	8072507	3002011	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Nucleoplasmin-like core domain	8072507	3002011	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleoplasmin-like core domain	8072507	3002011	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Nucleoplasmin	e8as5A1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Nucleoplasmin	ECOD (1.6)
C	Nucleoplasmin	e8as5C1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Nucleoplasmin	ECOD (1.6)
D	Nucleoplasmin	e8as5D1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Nucleoplasmin	ECOD (1.6)
E	Nucleoplasmin	e8as5E1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Nucleoplasmin	ECOD (1.6)
B	Nucleoplasmin	e8as5B1	A: beta sandwiches	X: jelly-roll	H: Nucleoplasmin-like/VP (viral coat and capsid proteins) (From Topology)	T: Nucleoplasmin-like/VP (viral coat and capsid proteins)	F: Nucleoplasmin	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF03066	Nucleoplasmin/nucleophosmin domain (Nucleoplasmin)	Nucleoplasmin/nucleophosmin domain	Nucleoplasmins are also known as chromatin decondensation proteins. They bind to core histones and transfer DNA to them in a reaction that requires ATP. This is thought to play a role in the assembly of regular nucleosomal arrays.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Nucleophosmin	protein binding binding histone binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding NF-kappaB binding RNA binding rRNA binding nucleic acid binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding protein binding binding histone binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding NF-kappaB binding RNA binding rRNA binding nucleic acid binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding core promoter sequence-specific DNA binding transcription regulatory region nucleic acid binding ribonucleoprotein complex binding protein-containing complex binding ribosomal large subunit binding ribosome binding molecular adaptor activity enzyme regulator activity catalytic activity, acting on a protein kinase activity protein kinase activity enzyme inhibitor activity transferase activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity catalytic activity kinase inhibitor activity kinase regulator activity chromatin binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity Tat protein binding unfolded protein binding identical protein binding protein homodimerization activity protein dimerization activity kinase binding enzyme binding protein kinase binding ribosomal small subunit binding	regulation of cellular process regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of catalytic activity regulation of transferase activity regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process regulation of cellular process regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of catalytic activity regulation of transferase activity regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process protein metabolic process phosphorus metabolic process protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process protein phosphorylation phosphorylation negative regulation of protein kinase activity by regulation of protein phosphorylation regulation of protein metabolic process negative regulation of metabolic process biological regulation negative regulation of molecular function primary metabolic process negative regulation of protein kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process cellular process metabolic process macromolecule metabolic process negative regulation of phosphorylation regulation of metabolic process cell cycle G2/M phase transition regulation of cell cycle phase transition regulation of cell cycle process positive regulation of biological process regulation of cell cycle G2/M phase transition cell cycle phase transition positive regulation of cell cycle G2/M phase transition positive regulation of cell cycle positive regulation of cell cycle phase transition positive regulation of cell cycle process cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process protein localization localization cellular localization cellular macromolecule localization macromolecule localization regulation of ribonuclease activity RNA metabolic process nucleic acid metabolic process regulation of endoribonuclease activity nucleobase-containing compound metabolic process regulation of RNA metabolic process regulation of hydrolase activity regulation of nucleobase-containing compound metabolic process nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport establishment of localization microtubule organizing center organization regulation of cellular component organization regulation of centrosome cycle microtubule cytoskeleton organization regulation of microtubule-based process cellular component organization centrosome duplication organelle organization centrosome cycle regulation of centrosome duplication microtubule-based process cellular component organization or biogenesis cytoskeleton organization establishment of protein localization nitrogen compound transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport protein localization to organelle protein import into nucleus intracellular protein transport cellular response to stimulus cellular response to stress response to stimulus response to stress cellular senescence positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity regulation of macromolecule biosynthetic process regulation of DNA-templated transcription DNA metabolic process DNA damage response DNA repair regulation of mRNA stability involved in cellular response to UV cellular response to environmental stimulus post-transcriptional regulation of gene expression cellular response to light stimulus regulation of biological quality RNA catabolic process mRNA catabolic process cellular response to radiation response to UV nucleobase-containing compound catabolic process negative regulation of gene expression negative regulation of macromolecule biosynthetic process nucleic acid catabolic process response to abiotic stimulus cellular response to abiotic stimulus response to light stimulus catabolic process macromolecule catabolic process regulation of mRNA catabolic process regulation of catabolic process mRNA metabolic process regulation of mRNA stability negative regulation of biosynthetic process regulation of RNA stability response to radiation cellular response to UV regulation of mRNA metabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process cellular response to nitrogen compound regulation of cellular response to stress regulation of translational initiation by eIF2 alpha phosphorylation translational initiation cellular response to dsRNA regulation of translational initiation response to nitrogen compound regulation of response to stimulus response to chemical regulation of translation in response to stress regulation of response to stress regulation of eIF2 alpha phosphorylation by dsRNA response to dsRNA translation cellular response to chemical stimulus regulation of translation regulation of translational initiation in response to stress membraneless organelle assembly cellular component biogenesis cellular component assembly regulation of centriole replication centriole replication centriole assembly organelle assembly regulation of cellular component biogenesis regulation of organelle organization regulation of organelle assembly establishment of organelle localization ribonucleoprotein complex biogenesis ribosomal subunit export from nucleus protein-containing complex localization ribosome biogenesis ribosomal small subunit export from nucleus organelle localization nuclear export ribosome localization negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death regulation of endodeoxyribonuclease activity ribosomal large subunit export from nucleus signaling signal transduction cell communication protein-containing complex organization protein-DNA complex assembly protein-DNA complex organization chromatin organization protein-containing complex assembly chromatin remodeling nucleosome assembly nucleosome organization cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of protein metabolic process positive regulation of translation positive regulation of gene expression ribosomal large subunit biogenesis developmental process myeloid leukocyte differentiation cellular developmental process hemopoiesis macrophage differentiation cell development mononuclear cell differentiation myeloid cell differentiation cell differentiation anatomical structure development leukocyte differentiation negative regulation of cell population proliferation regulation of cytoskeleton organization negative regulation of cell cycle negative regulation of centrosome cycle negative regulation of centrosome duplication negative regulation of cellular component organization negative regulation of cytoskeleton organization negative regulation of cell cycle process negative regulation of organelle organization ribosomal small subunit biogenesis ribosome assembly	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol anchoring junction cell junction focal adhesion cell-substrate junction membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen granular component centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton nucleoplasm protein-containing complex spindle pole centrosome spindle spindle pole protein-DNA complex ribonucleoprotein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR036824	Nucleoplasmin core domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR032569	Nucleophosmin, C-terminal	Domain
A, B, C, D, E	IPR004301	Nucleoplasmin family	Family
A, B, C, D, E	IPR024057	Nucleoplasmin core domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E	Pharos: P06748	acute myeloid leukemia acute promyelocytic leukemia cancer lung adenocarcinoma lymphomatoid papulosis lung cancer lymphoplasmacytic lymphoma malignant glioma MALT lymphoma myopathy oligodendroglioma plasma cell myeloma congenital anemia psoriasis Disease Models, Animal acute myeloid leukemia acute promyelocytic leukemia cancer lung adenocarcinoma lymphomatoid papulosis lung cancer lymphoplasmacytic lymphoma malignant glioma MALT lymphoma myopathy oligodendroglioma plasma cell myeloma congenital anemia psoriasis Disease Models, Animal glioblastoma large cell medulloblastoma lymphatic system disease malignant colon neoplasm medulloblastoma non-Hodgkin lymphoma osteoarthritis chronic obstructive pulmonary disease primary cutaneous anaplastic large cell lymphoma subependymal giant cell astrocytoma gastric cancer hematologic disease malignant ependymoma malignant pancreatic neoplasm myeloid leukemia non-small cell lung carcinoma atypical teratoid rhabdoid tumor pancreatic ductal adenocarcinoma primitive neuroectodermal tumor diabetes mellitus gastric neoplasm hereditary diffuse gastric adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.