8BEL

Cryo-EM structure of the Arabidopsis thaliana I+III2 supercomplex (CIII membrane domain)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	Cytochrom_B_C	e8belC2	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: Cytochrom_B_C	ECOD (1.6)
A [auth C]	Cytochrome_B	e8belC1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: Cytochrome_B	ECOD (1.6)
H [auth M]	Cytochrom_B_C	e8belM1	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: Cytochrom_B_C	ECOD (1.6)
H [auth M]	Cytochrome_B	e8belM2	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: Cytochrome_B	ECOD (1.6)
B [auth D]	Rieske_cytochrome_bc1	e8belD3	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: Rieske_cytochrome_bc1	ECOD (1.6)
B [auth D]	Rieske_6	e8belD2	A: few secondary structure elements	X: Trm112p-like (From Topology)	H: Trm112p-like (From Topology)	T: Trm112p-like	F: Rieske_6	ECOD (1.6)
B [auth D]	F_UNCLASSIFIED	e8belD1	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: F_UNCLASSIFIED	ECOD (1.6)
I [auth N]	Rieske_cytochrome_bc1	e8belN3	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: Rieske_cytochrome_bc1	ECOD (1.6)
I [auth N]	Rieske_6	e8belN1	A: few secondary structure elements	X: Trm112p-like (From Topology)	H: Trm112p-like (From Topology)	T: Trm112p-like	F: Rieske_6	ECOD (1.6)
I [auth N]	F_UNCLASSIFIED	e8belN2	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth E]	Cytochrom_C1_N	e8belE2	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C1_N	ECOD (1.6)
C [auth E]	Cytochrom_C1_C	e8belE1	A: extended segments	X: cytochrome c1 transmembrane anchor (From Topology)	H: cytochrome c1 transmembrane anchor (From Topology)	T: cytochrome c1 transmembrane anchor	F: Cytochrom_C1_C	ECOD (1.6)
J [auth O]	Cytochrom_C1_N	e8belO1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C1_N	ECOD (1.6)
J [auth O]	Cytochrom_C1_C	e8belO2	A: extended segments	X: cytochrome c1 transmembrane anchor (From Topology)	H: cytochrome c1 transmembrane anchor (From Topology)	T: cytochrome c1 transmembrane anchor	F: Cytochrom_C1_C	ECOD (1.6)
K [auth Q]	UcrQ	e8belQ1	A: extended segments	X: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UcrQ	ECOD (1.6)
D [auth G]	UcrQ	e8belG1	A: extended segments	X: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UcrQ	ECOD (1.6)
E [auth H]	UCR_hinge	e8belH1	A: alpha bundles	X: cytochrome bc1 complex 11 kDa protein-like	H: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_hinge	ECOD (1.6)
L [auth R]	UCR_hinge	e8belR1	A: alpha bundles	X: cytochrome bc1 complex 11 kDa protein-like	H: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_hinge	ECOD (1.6)
F [auth I]	UCR_UQCRX_QCR9	e8belI1	A: extended segments	X: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_UQCRX_QCR9	ECOD (1.6)
M [auth S]	UCR_UQCRX_QCR9	e8belS1	A: extended segments	X: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_UQCRX_QCR9	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], H [auth M]	PF00032	Cytochrome b(C-terminal)/b6/petD (Cytochrom_B_C)	Cytochrome b(C-terminal)/b6/petD	-	Domain
A [auth C], H [auth M]	PF00033	Cytochrome b/b6/petB (Cytochrome_B)	Cytochrome b/b6/petB	-	Domain
B [auth D], I [auth N]	PF00355	Rieske [2Fe-2S] domain (Rieske)	Rieske [2Fe-2S] domain	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in ...	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilises the protein [4].	Domain
C [auth E], J [auth O]	PF02167	Cytochrome C1 family (Cytochrom_C1)	Cytochrome C1 family	-	Family
E [auth H], L [auth R]	PF02320	Ubiquinol-cytochrome C reductase hinge protein (UCR_hinge)	Ubiquinol-cytochrome C reductase hinge protein	-	Family
F [auth I], M [auth S]	PF05365	Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like (UCR_UQCRX_QCR9)	Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], H [auth M]	Cytochrome b	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex
B [auth D], I [auth N]	Cytochrome b-c1 complex subunit Rieske-1, mitochondrial	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	-	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex plastid
C [auth E], J [auth O]	Cytochrome c1 2, heme protein, mitochondrial	binding organic cyclic compound binding tetrapyrrole binding heme binding electron transfer activity cation binding ion binding metal ion binding small molecule binding	-	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane plastid vacuole
D [auth G], K [auth Q]	Cytochrome b-c1 complex subunit 8-1, mitochondrial	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex
E [auth H], L [auth R]	Cytochrome b-c1 complex subunit 6-1, mitochondrial	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope cellular anatomical structure mitochondrial envelope organelle cytoplasm organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex
F [auth I], M [auth S]	Cytochrome b-c1 complex subunit 9, mitochondrial	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex
G [auth J], N [auth T]	Cytochrome b-c1 complex subunit 10, mitochondrial	-	-	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], H [auth M]	IPR036150	Cytochrome b/b6, C-terminal domain superfamily	Homologous Superfamily
A [auth C], H [auth M]	IPR027387	Cytochrome b/b6-like domain superfamily	Homologous Superfamily
A [auth C], H [auth M]	IPR048260	Cytochrome b/b6, C-terminal domain, eukaryotic/bacterial	Domain
A [auth C], H [auth M]	IPR016174	Di-haem cytochrome, transmembrane	Homologous Superfamily
A [auth C], H [auth M]	IPR005798	Cytochrome b/b6, C-terminal	Domain
A [auth C], H [auth M]	IPR048259	Cytochrome b/b6, N-terminal domain, eukaryotic/bacterial	Domain
A [auth C], H [auth M]	IPR030689	Cytochrome b	Family
A [auth C], H [auth M]	IPR005797	Cytochrome b/b6, N-terminal domain	Domain
B [auth D], I [auth N]	IPR036922	Rieske [2Fe-2S] iron-sulphur domain superfamily	Homologous Superfamily
B [auth D], I [auth N]	IPR014349	Rieske iron-sulphur protein	Family
B [auth D], I [auth N]	IPR004192	Cytochrome b-c1 complex subunit Rieske, transmembrane domain	Domain
B [auth D], I [auth N]	IPR017941	Rieske [2Fe-2S] iron-sulphur domain	Domain
B [auth D], I [auth N]	IPR005805	Rieske iron-sulphur protein, C-terminal	Domain
B [auth D], I [auth N]	IPR006317	Ubiquinol-cytochrome c reductase, iron-sulphur subunit	Domain
C [auth E], J [auth O]	IPR036909	Cytochrome c-like domain superfamily	Homologous Superfamily
C [auth E], J [auth O]	IPR002326	Cytochrome c1	Family
C [auth E], J [auth O]	IPR009056	Cytochrome c-like domain	Domain
C [auth E], J [auth O]	IPR021157	Cytochrome c1, transmembrane anchor, C-terminal	Homologous Superfamily
D [auth G], K [auth Q]	IPR036642	Cytochrome b-c1 complex subunit 8 superfamily	Homologous Superfamily
D [auth G], K [auth Q]	IPR020101	Cytochrome b-c1 complex subunit 8, plants	Family
E [auth H], L [auth R]	IPR003422	Cytochrome b-c1 complex, subunit 6	Family
E [auth H], L [auth R]	IPR023184	Ubiquinol-cytochrome C reductase hinge domain	Domain
E [auth H], L [auth R]	IPR036811	Ubiquinol-cytochrome C reductase hinge domain superfamily	Homologous Superfamily
F [auth I], M [auth S]	IPR008027	Cytochrome b-c1 complex subunit 9	Family
F [auth I], M [auth S]	IPR036656	Cytochrome b-c1 complex subunit 9 superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth C], B [auth D], C [auth E], D [auth G], E [auth H] A [auth C], B [auth D], C [auth E], D [auth G], E [auth H], F [auth I], G [auth J], H [auth M], I [auth N], J [auth O], K [auth Q], L [auth R], M [auth S], N [auth T]	OPM	Transmembrane	Alpha-helical polytopic	Electron transport chain complex III (bc1 and b6f) superfamily	Cytochrome bc1 and b6f complexes

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth C], B [auth D], C [auth E], D [auth G], E [auth H] A [auth C], B [auth D], C [auth E], D [auth G], E [auth H], F [auth I], G [auth J], H [auth M], I [auth N], J [auth O], K [auth Q], L [auth R], M [auth S], N [auth T]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth C], B [auth D], C [auth E], D [auth G], E [auth H] A [auth C], B [auth D], C [auth E], D [auth G], E [auth H], F [auth I], G [auth J], H [auth M], I [auth N], J [auth O], K [auth Q], L [auth R], M [auth S], N [auth T]	MemProtMD	Annotated as membrane protein by MemProtMD