8CTE | pdb_00008cte

Class 2 of erythrocyte ankyrin-1 complex (Composite map)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
I [auth P]	SCOP2B Superfamily	Nucleobase/cation symporter 2, NCS2-like	8092954	3002647	SCOP2B (2022-06-29)
I [auth P]	SCOP2B Superfamily	Phoshotransferase/anion transport protein	8033412	3000490	SCOP2B (2022-06-29)
J [auth T]	SCOP2B Superfamily	Phoshotransferase/anion transport protein	8033412	3000490	SCOP2B (2022-06-29)
J [auth T]	SCOP2B Superfamily	Nucleobase/cation symporter 2, NCS2-like	8092954	3002647	SCOP2B (2022-06-29)
K [auth S]	SCOP2B Superfamily	Aquaporin-like	8036332	3000508	SCOP2B (2022-06-29)
L [auth O]	SCOP2B Superfamily	Aquaporin-like	8036332	3000508	SCOP2B (2022-06-29)
M [auth R]	SCOP2B Superfamily	Aquaporin-like	8036332	3000508	SCOP2B (2022-06-29)
N [auth M]	SCOP2B Superfamily	Aquaporin-like	8036332	3000508	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ank_2	e8cteA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: Ank_2	ECOD (1.6)
I [auth P]	HCO3_cotransp	e8cteP1	A: alpha complex topology	X: Uracil Transporter UraA (From Topology)	H: Uracil Transporter UraA (From Topology)	T: Uracil Transporter UraA	F: HCO3_cotransp	ECOD (1.6)
I [auth P]	Band_3_cyto	e8cteP2	A: a+b three layers	X: Phoshotransferase/anion transport protein (From Topology)	H: Phoshotransferase/anion transport protein (From Topology)	T: Phoshotransferase/anion transport protein	F: Band_3_cyto	ECOD (1.6)
J [auth T]	HCO3_cotransp	e8cteT1	A: alpha complex topology	X: Uracil Transporter UraA (From Topology)	H: Uracil Transporter UraA (From Topology)	T: Uracil Transporter UraA	F: HCO3_cotransp	ECOD (1.6)
J [auth T]	Band_3_cyto	e8cteT2	A: a+b three layers	X: Phoshotransferase/anion transport protein (From Topology)	H: Phoshotransferase/anion transport protein (From Topology)	T: Phoshotransferase/anion transport protein	F: Band_3_cyto	ECOD (1.6)
C [auth X]	Transglut_N	e8cteX2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Transglut_N	ECOD (1.6)
C [auth X]	Transglut_C_1	e8cteX1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Transglut_C_1	ECOD (1.6)
C [auth X]	Transglut_C	e8cteX3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Transglut_C	ECOD (1.6)
C [auth X]	Transglut_core	e8cteX4	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Transglut_core	ECOD (1.6)
D [auth K]	F_UNCLASSIFIED	e8cteK1	A: alpha complex topology	X: Ammonium transporter-related (From Homology)	H: Ammonium transporter-related	T: Ammonium transporter	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth L]	Ammonium_transp_1	e8cteL1	A: alpha complex topology	X: Ammonium transporter-related (From Homology)	H: Ammonium transporter-related	T: Ammonium transporter	F: Ammonium_transp_1	ECOD (1.6)
F [auth Q]	Ammonium_transp_1	e8cteQ1	A: alpha complex topology	X: Ammonium transporter-related (From Homology)	H: Ammonium transporter-related	T: Ammonium transporter	F: Ammonium_transp_1	ECOD (1.6)
G [auth N]	Glycophorin_A	e8cteN1	A: extended segments	X: Glycophorin-A transmembrane domain (From Topology)	H: Glycophorin-A transmembrane domain (From Topology)	T: Glycophorin-A transmembrane domain	F: Glycophorin_A	ECOD (1.6)
H [auth D]	Glycophorin_A	e8cteD1	A: extended segments	X: Glycophorin-A transmembrane domain (From Topology)	H: Glycophorin-A transmembrane domain (From Topology)	T: Glycophorin-A transmembrane domain	F: Glycophorin_A	ECOD (1.6)
K [auth S]	MIP	e8cteS1	A: alpha complex topology	X: Aquaporin-like (From Topology)	H: Aquaporin-like (From Topology)	T: Aquaporin-like	F: MIP	ECOD (1.6)
L [auth O]	MIP	e8cteO1	A: alpha complex topology	X: Aquaporin-like (From Topology)	H: Aquaporin-like (From Topology)	T: Aquaporin-like	F: MIP	ECOD (1.6)
M [auth R]	MIP	e8cteR1	A: alpha complex topology	X: Aquaporin-like (From Topology)	H: Aquaporin-like (From Topology)	T: Aquaporin-like	F: MIP	ECOD (1.6)
N [auth M]	MIP	e8cteM1	A: alpha complex topology	X: Aquaporin-like (From Topology)	H: Aquaporin-like (From Topology)	T: Aquaporin-like	F: MIP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
J [auth T]	3.40.930.10	Alpha Beta	3-Layer(aba) Sandwich	Mannitol-specific EII	Chain A	CATH (utative)
C [auth X]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
C [auth X]	3.90.260.10	Alpha Beta	Alpha-Beta Complex	Coagulation Factor XIII	Chain A, domain 2	CATH (utative)
D [auth K]	1.10.3430.10	Mainly Alpha	Orthogonal Bundle	Ammonium transporter fold	Ammonium transporter AmtB like domains	CATH (utative)
E [auth L]	1.10.3430.10	Mainly Alpha	Orthogonal Bundle	Ammonium transporter fold	Ammonium transporter AmtB like domains	CATH (utative)
F [auth Q]	1.10.3430.10	Mainly Alpha	Orthogonal Bundle	Ammonium transporter fold	Ammonium transporter AmtB like domains	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00023	Ankyrin repeat (Ank)	Ankyrin repeat	-	Repeat
B [auth W], I [auth P], J [auth T]	PF00955	HCO3- transporter integral membrane domain (HCO3_cotransp)	HCO3- transporter integral membrane domain	This family contains Band 3 anion exchange proteins that exchange CL-/HCO3- such as Swiss:P48751. This family also includes cotransporters of Na+/HCO3- such as Swiss:O15153.	Domain
B [auth W], I [auth P], J [auth T]	PF07565	Band 3 cytoplasmic domain (Band_3_cyto)	Band 3 cytoplasmic domain	This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic ...	This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk). [1]	Domain
C [auth X]	PF00868	Transglutaminase family (Transglut_N)	Transglutaminase family		Domain
C [auth X]	PF00927	Transglutaminase family, C-terminal ig like domain (Transglut_C)	Transglutaminase family, C-terminal ig like domain		Domain
C [auth X]	PF01841	Transglutaminase-like superfamily (Transglut_core)	Transglutaminase-like superfamily	This domain is found in animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that ...	This domain is found in animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterised transglutaminase, the human blood clotting factor XIIIa' [1]. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase [2], it is proposed that many, if not all, microbial homologues of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease. [3]	Domain
D [auth K]	PF00909	Ammonium Transporter Family (Ammonium_transp)	Ammonium Transporter Family	-	Family
E [auth L], F [auth Q]	PF00909	Ammonium Transporter Family (Ammonium_transp)	Ammonium Transporter Family	-	Family
K [auth S], L [auth O], M [auth R], N [auth M]	PF00230	Major intrinsic protein (MIP)	Major intrinsic protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ankyrin-1	cytoskeletal protein binding spectrin binding protein-containing complex binding protein binding binding protein phosphatase binding phosphatase binding enzyme binding transmembrane transporter binding structural constituent of cytoskeleton structural molecule activity protein-macromolecule adaptor activity cytoskeletal anchor activity molecular adaptor activity cytoskeletal protein binding spectrin binding protein-containing complex binding protein binding binding protein phosphatase binding phosphatase binding enzyme binding transmembrane transporter binding structural constituent of cytoskeleton structural molecule activity protein-macromolecule adaptor activity cytoskeletal anchor activity molecular adaptor activity ATPase binding	positive regulation of organelle organization regulation of biological process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization biological regulation positive regulation of biological process regulation of organelle organization cellular component organization organelle organization cellular process cellular component organization or biogenesis positive regulation of cellular process protein localization positive regulation of organelle organization regulation of biological process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization biological regulation positive regulation of biological process regulation of organelle organization cellular component organization organelle organization cellular process cellular component organization or biogenesis positive regulation of cellular process protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity maintenance of cell polarity maintenance of epithelial cell apical/basal polarity maintenance of apical/basal cell polarity establishment or maintenance of apical/basal cell polarity establishment or maintenance of cell polarity transport establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport establishment of localization Golgi vesicle transport vesicle-mediated transport cellular response to stimulus response to stimulus signaling signal transduction cell communication cytoskeleton organization secretion by cell exocytosis secretion export from cell	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane M band intracellular anatomical structure intracellular membraneless organelle sarcomere cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane M band intracellular anatomical structure intracellular membraneless organelle sarcomere intracellular organelle organelle membraneless organelle contractile muscle fiber A band cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex Z disc I band ankyrin-1 complex protein-containing complex membrane protein complex cytosol sarcolemma basal part of cell basal plasma membrane basolateral plasma membrane cell projection neuron projection plasma membrane bounded cell projection cytoskeleton axon cell leading edge axolemma leading edge membrane neuron projection membrane main axon cell projection membrane membrane-bounded organelle intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum sarcoplasmic reticulum spectrin-associated cytoskeleton cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane
B [auth W], I [auth P], J [auth T]	Band 3 anion transport protein	cytoskeletal protein binding ankyrin binding protein binding binding hemoglobin binding bicarbonate transmembrane transporter activity transporter activity transmembrane transporter activity organic anion transmembrane transporter activity chloride transmembrane transporter activity monoatomic anion transmembrane transporter activity bicarbonate:monoatomic anion antiporter activity secondary active transmembrane transporter activity antiporter activity cytoskeletal protein binding ankyrin binding protein binding binding hemoglobin binding bicarbonate transmembrane transporter activity transporter activity transmembrane transporter activity organic anion transmembrane transporter activity chloride transmembrane transporter activity monoatomic anion transmembrane transporter activity bicarbonate:monoatomic anion antiporter activity secondary active transmembrane transporter activity antiporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity chloride:bicarbonate antiporter activity monoatomic ion transmembrane transporter activity inorganic anion transmembrane transporter activity solute:inorganic anion antiporter activity protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity identical protein binding protein homodimerization activity protein dimerization activity	multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding developmental process erythrocyte development cellular developmental process multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding developmental process erythrocyte development cellular developmental process homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process cell differentiation anatomical structure development myeloid cell development homeostasis of number of cells cellular process myeloid cell homeostasis erythrocyte homeostasis transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport inorganic anion transport cellular homeostasis chemical homeostasis monoatomic ion homeostasis intracellular chemical homeostasis intracellular monoatomic ion homeostasis bicarbonate transport organic anion transport protein localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane renal system process system process regulation of urine volume negative regulation of urine volume membrane organization phospholipid translocation lipid localization phospholipid transport lipid transport lipid translocation regulation of membrane lipid distribution plasma membrane phospholipid scrambling cellular component organization plasma membrane organization cellular component organization or biogenesis endomembrane system organization organophosphate ester transport pH elevation regulation of pH monoatomic cation homeostasis ribonucleotide catabolic process pyridine nucleotide catabolic process regulation of cellular process negative regulation of small molecule metabolic process negative regulation of glycolytic process oxoacid metabolic process negative regulation of biological process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process negative regulation of ATP metabolic process regulation of primary metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process negative regulation of nucleotide metabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process negative regulation of carbohydrate metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process regulation of biological process negative regulation of metabolic process negative regulation of purine nucleotide catabolic process purine nucleoside diphosphate metabolic process primary metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process metabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process regulation of metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process negative regulation of cellular process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process negative regulation of nucleotide catabolic process negative regulation of catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process regulation of glycolytic process through fructose-6-phosphate ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process negative regulation of phosphorus metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process negative regulation of glycolytic process through fructose-6-phosphate glycolytic process through fructose-6-phosphate regulation of intracellular pH intracellular monoatomic cation homeostasis regulation of cellular pH	cellular anatomical structure membrane intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril cellular anatomical structure membrane intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex ankyrin-1 complex protein-containing complex membrane protein complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane blood microparticle cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane cell cortex cortical cytoskeleton cytoskeleton
C [auth X]	Protein 4.2	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding structural constituent of cytoskeleton structural molecule activity aminoacyltransferase activity protein-glutamine gamma-glutamyltransferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity	developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis metabolic process cellular process primary metabolic process developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process hemoglobin metabolic process immune system development multicellular organism development multicellular organismal process spleen development immune system process animal organ development hematopoietic or lymphoid organ development system development multicellular organismal-level iron ion homeostasis inorganic ion homeostasis multicellular organismal-level homeostasis chemical homeostasis homeostatic process multicellular organismal-level chemical homeostasis monoatomic ion homeostasis monoatomic cation homeostasis erythrocyte development cellular developmental process hemopoiesis cell development erythrocyte maturation developmental maturation erythrocyte differentiation anatomical structure maturation myeloid cell differentiation cell differentiation myeloid cell development homeostasis of number of cells cell maturation myeloid cell homeostasis erythrocyte homeostasis	ankyrin-1 complex protein-containing complex cellular anatomical structure membrane membrane protein complex intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle cell periphery plasma membrane cell cortex ankyrin-1 complex protein-containing complex cellular anatomical structure membrane membrane protein complex intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle cell periphery plasma membrane cell cortex cortical cytoskeleton cytoplasm
D [auth K]	Blood group Rh(CE) polypeptide	ammonium channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity transporter activity transmembrane transporter activity	inorganic ion homeostasis chemical homeostasis homeostatic process ammonium homeostasis transmembrane transport localization nitrogen compound transport transport ammonium transmembrane transport cellular process inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport	cell periphery cellular anatomical structure plasma membrane membrane ankyrin-1 complex protein-containing complex membrane protein complex
E [auth L], F [auth Q]	Ammonium transporter Rh type A	passive transmembrane transporter activity narrow pore channel activity leak channel activity channel activity transporter activity transmembrane transporter activity carbon dioxide transmembrane transporter activity organic cation transmembrane transporter activity amine transmembrane transporter activity methylammonium transmembrane transporter activity cytoskeletal protein binding ankyrin binding protein binding binding passive transmembrane transporter activity narrow pore channel activity leak channel activity channel activity transporter activity transmembrane transporter activity carbon dioxide transmembrane transporter activity organic cation transmembrane transporter activity amine transmembrane transporter activity methylammonium transmembrane transporter activity cytoskeletal protein binding ankyrin binding protein binding binding ammonium channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity	inorganic ion homeostasis chemical homeostasis homeostatic process ammonium homeostasis transmembrane transport localization nitrogen compound transport transport ammonium transmembrane transport cellular process inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport one-carbon compound transport inorganic ion homeostasis chemical homeostasis homeostatic process ammonium homeostasis transmembrane transport localization nitrogen compound transport transport ammonium transmembrane transport cellular process inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport one-carbon compound transport gas transport carbon dioxide transport carbon dioxide transmembrane transport developmental process multicellular organismal process erythrocyte development cellular developmental process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process cell differentiation anatomical structure development myeloid cell development homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis cellular homeostasis monoatomic ion homeostasis intracellular chemical homeostasis intracellular monoatomic ion homeostasis bicarbonate transport organic anion transport multicellular organismal-level iron ion homeostasis multicellular organismal-level chemical homeostasis monoatomic cation homeostasis methylammonium transmembrane transport organic cation transport amine transport methylammonium transport	cellular anatomical structure membrane ankyrin-1 complex protein-containing complex membrane protein complex cell periphery plasma membrane
G [auth N], H [auth D]	Glycophorin-A	protein binding binding virus receptor activity exogenous protein binding identical protein binding	-	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane ankyrin-1 complex protein-containing complex membrane protein complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane ankyrin-1 complex protein-containing complex membrane protein complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
K [auth S], L [auth O], M [auth R], N [auth M]	Aquaporin-1	monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity water transmembrane transporter activity nitric oxide transmembrane transporter activity protein binding binding signaling receptor binding ephrin receptor binding monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity water transmembrane transporter activity nitric oxide transmembrane transporter activity protein binding binding signaling receptor binding ephrin receptor binding intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity intracellularly cyclic nucleotide-activated monoatomic cation channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity channel activity ligand-gated monoatomic cation channel activity cyclic nucleotide-activated monoatomic ion channel activity intracellularly cGMP-activated cation channel activity identical protein binding carbon dioxide transmembrane transporter activity potassium channel activity water channel activity glycerol transmembrane transporter activity polyol transmembrane transporter activity carbohydrate transmembrane transporter activity ammonium channel activity hydrogen peroxide channel activity	regulation of body fluid levels multicellular organismal process secretion by tissue secretion transport biological regulation cerebrospinal fluid secretion establishment of localization body fluid secretion localization regulation of biological quality kidney epithelium development nephron tubule development metanephric epithelium development regulation of body fluid levels multicellular organismal process secretion by tissue secretion transport biological regulation cerebrospinal fluid secretion establishment of localization body fluid secretion localization regulation of biological quality kidney epithelium development nephron tubule development metanephric epithelium development metanephric proximal tubule development proximal straight tubule development renal system development multicellular organism development metanephros development renal tubule development anatomical structure development nephron development metanephric nephron epithelium development system development nephron epithelium development developmental process epithelium development proximal tubule development tube development metanephric nephron tubule development animal organ development tissue development metanephric proximal straight tubule development metanephric tubule development kidney development renal system process system process homeostatic process fluid transport water transport renal water transport multicellular organismal-level homeostasis chemical homeostasis multicellular organismal-level water homeostasis multicellular organismal-level chemical homeostasis renal water homeostasis response to decreased oxygen levels cellular response to stimulus response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress response to chemical response to oxygen levels response to abiotic stimulus cellular process head development lateral ventricle development forebrain development brain development nervous system development central nervous system development ventricular system development telencephalon development response to lipid response to oxygen-containing compound cellular response to oxygen-containing compound response to retinoic acid cellular response to retinoic acid cellular response to lipid ameboidal-type cell migration cell migration fibroblast migration cell motility metanephric proximal convoluted tubule segment 2 development proximal convoluted tubule development proximal convoluted tubule segment 2 development metanephric proximal convoluted tubule development response to ketone cellular response to endogenous stimulus response to hormone response to steroid hormone cellular response to ketone cellular response to steroid hormone stimulus cellular response to hormone stimulus response to endogenous stimulus cellular response to dexamethasone stimulus response to glucocorticoid cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid response to dexamethasone response to osmotic stress cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus hyperosmotic response cellular hyperosmotic response cellular response to abiotic stimulus transepithelial water transport epithelial fluid transport transepithelial transport one-carbon compound transport gas transport carbon dioxide transport transmembrane transport carbon dioxide transmembrane transport anatomical structure morphogenesis odontogenesis animal organ morphogenesis pancreatic juice secretion digestive system process digestion camera-type eye morphogenesis sensory organ development eye development visual system development eye morphogenesis sensory organ morphogenesis camera-type eye development sensory system development cellular response to metal ion response to mercury ion response to metal ion cellular response to mercury ion biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus regulation of localization regulation of system process positive regulation of biological process saliva secretion positive regulation of secretion regulation of saliva secretion positive regulation of digestive system process regulation of multicellular organismal process regulation of biological process regulation of transport regulation of digestive system process regulation of secretion positive regulation of transport positive regulation of multicellular organismal process positive regulation of saliva secretion cellular response to salt stress response to salt stress lipid digestion vesicle organization cellular component organization organelle organization secretory granule organization cellular component organization or biogenesis endomembrane system organization cellular response to nitrogen compound response to nitrogen compound cellular response to nitric oxide response to nitric oxide cellular response to reactive nitrogen species loop of Henle development metanephric loop of Henle development metanephric descending thin limb development descending thin limb development nitrogen compound transport ammonium transmembrane transport inorganic ion transmembrane transport inorganic cation transmembrane transport cellular homeostasis signaling hormone secretion cell communication peptide secretion secretion by cell amide transport signal release corticotropin secretion regulation of hormone levels cell-cell signaling export from cell peptide transport endocrine hormone secretion endocrine process peptide hormone secretion hormone transport glycerol transmembrane transport polyol transmembrane transport carbohydrate transport organic hydroxy compound transport carbohydrate transmembrane transport establishment or maintenance of actin cytoskeleton polarity establishment or maintenance of cytoskeleton polarity actin cytoskeleton organization actin filament-based process establishment or maintenance of cell polarity cytoskeleton organization renal absorption renal water absorption regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death fibroblast proliferation cell population proliferation positive regulation of cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation positive regulation of cellular process cGMP-mediated signaling intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of locomotion regulation of cell motility regulation of fibroblast migration positive regulation of fibroblast migration positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration locomotion regulation of cellular component size cell volume homeostasis regulation of cell size regulation of anatomical structure size metanephric glomerulus vasculature development metanephric glomerulus development vasculature development kidney vasculature development circulatory system development glomerulus development renal system vasculature development glomerulus vasculature development metanephric nephron development blood vessel development response to organophosphorus response to purine-containing compound response to cAMP cellular response to cAMP intracellular water homeostasis intracellular chemical homeostasis glomerular filtration renal filtration cellular localization establishment of localization in cell monoatomic ion transport potassium ion transport monoatomic cation transport metal ion transport response to copper ion cellular response to copper ion cellular response to oxidative stress cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species response to mechanical stimulus cellular response to mechanical stimulus cellular response to external stimulus nitric oxide transport response to light stimulus cellular response to radiation response to UV cellular response to light stimulus response to radiation cellular response to UV regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process tube morphogenesis regulation of anatomical structure morphogenesis regulation of multicellular organismal development blood vessel morphogenesis positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis wound healing response to wounding sensory perception nervous system process sensory perception of pain	ankyrin-1 complex protein-containing complex cellular anatomical structure membrane membrane protein complex apical part of cell membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope ankyrin-1 complex protein-containing complex cellular anatomical structure membrane membrane protein complex apical part of cell membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cell periphery sarcolemma plasma membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane cluster of actin-based cell projections brush border cytoplasm axon cell projection neuron projection plasma membrane bounded cell projection apical plasma membrane brush border membrane cell projection membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A	IPR040745	Ankyrin, UPA domain	Domain
A	IPR000906	ZU5 domain	Domain
A	IPR002110	Ankyrin repeat	Repeat
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR051165	Multifunctional Ankyrin Repeat Domain-Containing Protein	Family
A	IPR000488	Death domain	Domain
B [auth W], I [auth P], J [auth T]	IPR013769	Band 3 cytoplasmic domain	Domain
B [auth W], I [auth P], J [auth T]	IPR001717	Anion exchange protein	Family
B [auth W], I [auth P], J [auth T]	IPR003020	Bicarbonate transporter, eukaryotic	Family
B [auth W], I [auth P], J [auth T]	IPR011531	Bicarbonate transporter-like, transmembrane domain	Domain
B [auth W], I [auth P], J [auth T]	IPR002977	Anion exchange protein 1	Family
B [auth W], I [auth P], J [auth T]	IPR016152	Phosphotransferase/anion transporter	Homologous Superfamily
B [auth W], I [auth P], J [auth T]	IPR018241	Anion exchange, conserved site	Conserved Site
C [auth X]	IPR036985	Transglutaminase-like superfamily	Homologous Superfamily
C [auth X]	IPR036238	Transglutaminase, C-terminal domain superfamily	Homologous Superfamily
C [auth X]	IPR013808	Transglutaminase, active site	Active Site
C [auth X]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C [auth X]	IPR002931	Transglutaminase-like	Domain
C [auth X]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
C [auth X]	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
C [auth X]	IPR001102	Transglutaminase, N-terminal	Domain
C [auth X]	IPR008958	Transglutaminase, C-terminal	Domain
C [auth X]	IPR050779	Protein-glutamine gamma-glutamyltransferases	Family
C [auth X]	IPR023608	Protein-glutamine gamma-glutamyltransferase, animal	Family
D [auth K]	IPR002229	Blood group Rhesus C/E/D polypeptide	Family
D [auth K]	IPR029020	Ammonium/urea transporter	Homologous Superfamily
D [auth K]	IPR024041	Ammonium transporter AmtB-like domain	Domain
E [auth L], F [auth Q]	IPR002229	Blood group Rhesus C/E/D polypeptide	Family
E [auth L], F [auth Q]	IPR029020	Ammonium/urea transporter	Homologous Superfamily
E [auth L], F [auth Q]	IPR024041	Ammonium transporter AmtB-like domain	Domain
G [auth N], H [auth D]	IPR018938	Glycophorin, conserved site	Conserved Site
G [auth N], H [auth D]	IPR001195	Glycophorin	Family
G [auth N], H [auth D]	IPR049535	Glycophorin A/B	Family
K [auth S], L [auth O], M [auth R], N [auth M]	IPR023271	Aquaporin-like	Homologous Superfamily
K [auth S], L [auth O], M [auth R], N [auth M]	IPR034294	Aquaporin transporter	Family
K [auth S], L [auth O], M [auth R], N [auth M]	IPR023274	Aquaporin 1	Family
K [auth S], L [auth O], M [auth R], N [auth M]	IPR022357	Major intrinsic protein, conserved site	Conserved Site
K [auth S], L [auth O], M [auth R], N [auth M]	IPR000425	Major intrinsic protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P16157	hereditary spherocytosis hereditary spherocytosis type 1 8p11.2 deletion syndrome Bone Diseases, Developmental familial hemolytic anemia hereditary elliptocytosis pilocytic astrocytoma subependymal giant cell astrocytoma hemolytic anemia myopathy primitive neuroectodermal tumor type 2 diabetes mellitus congenital anemia malignant ependymoma maturity-onset diabetes of the young hereditary spherocytosis hereditary spherocytosis type 1 8p11.2 deletion syndrome Bone Diseases, Developmental familial hemolytic anemia hereditary elliptocytosis pilocytic astrocytoma subependymal giant cell astrocytoma hemolytic anemia myopathy primitive neuroectodermal tumor type 2 diabetes mellitus congenital anemia malignant ependymoma maturity-onset diabetes of the young osteosarcoma atypical teratoid rhabdoid tumor cystic fibrosis glioblastoma malignant glioma medulloblastoma
B [auth W], I [auth P], J [auth T]	Pharos: P02730	hereditary elliptocytosis hereditary spherocytosis renal tubular acidosis hereditary spherocytosis type 4 cryohydrocytosis southeast Asian ovalocytosis hemolytic anemia renal tubular acidosis, distal, 4, with hemolytic anemia malaria hematologic disease Ovalocytosis, Malaysian-Melanesian-Filipino Type autosomal dominant distal renal tubular acidosis familial hemolytic anemia distal renal tubular acidosis MALT lymphoma hereditary elliptocytosis hereditary spherocytosis renal tubular acidosis hereditary spherocytosis type 4 cryohydrocytosis southeast Asian ovalocytosis hemolytic anemia renal tubular acidosis, distal, 4, with hemolytic anemia malaria hematologic disease Ovalocytosis, Malaysian-Melanesian-Filipino Type autosomal dominant distal renal tubular acidosis familial hemolytic anemia distal renal tubular acidosis MALT lymphoma renal tubular acidosis, distal, 3, with or without sensorineural hearing loss tuberculosis psoriasis osteosarcoma
C [auth X]	Pharos: P16452	hereditary spherocytosis hereditary spherocytosis type 5 familial hemolytic anemia Anemia, hereditary spherocytic hemolytic ductal breast carcinoma in situ MALT lymphoma congenital anemia osteosarcoma hemolytic anemia invasive ductal breast carcinoma ovarian cancer
D [auth K]	Pharos: P18577	familial hemolytic anemia Rh deficiency syndrome Anemia, Hemolytic, Congenital MALT lymphoma ovarian cancer spina bifida blood group incompatibility medulloblastoma osteosarcoma
E [auth L], F [auth Q]	Pharos: Q02094	Rh deficiency syndrome overhydrated hereditary stomatocytosis familial hemolytic anemia congenital anemia hemolytic anemia osteosarcoma Cytopenia large cell medulloblastoma MALT lymphoma psoriasis
G [auth N], H [auth D]	Pharos: P02724	malaria skin neoplasm skin cancer chronic obstructive pulmonary disease osteosarcoma sarcoidosis MALT lymphoma
K [auth S], L [auth O], M [auth R], N [auth M]	Pharos: P29972	hyperthyroidism salivary gland adenoid cystic carcinoma sarcomatoid carcinoma toxic shock syndrome carcinoma hypertensive disorder adenoid cystic carcinoma Pain autosomal recessive polycystic kidney disease choledochal cyst pancreatic intraductal papillary-mucinous neoplasm glioblastoma idiopathic pulmonary arterial hypertension pterygium lung adenocarcinoma hyperthyroidism salivary gland adenoid cystic carcinoma sarcomatoid carcinoma toxic shock syndrome carcinoma hypertensive disorder adenoid cystic carcinoma Pain autosomal recessive polycystic kidney disease choledochal cyst pancreatic intraductal papillary-mucinous neoplasm glioblastoma idiopathic pulmonary arterial hypertension pterygium lung adenocarcinoma lymphatic system disease bone disease nephrolithiasis ovarian cancer ductal breast carcinoma in situ pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia interstitial cystitis pulmonary arterial hypertension lung cancer salivary gland cancer malignant ependymoma spinal cord injury astrocytic tumor malignant pancreatic neoplasm subependymal giant cell astrocytoma breast cancer mammary neoplasms, animal transitional cell carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma gastric carcinoma pilocytic astrocytoma psoriasis invasive ductal breast carcinoma lung carcinoma malignant glioma MALT lymphoma breast carcinoma undifferentiated carcinoma osteosarcoma Down syndrome

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B [auth W], C [auth X], D [auth K], E [auth L] A, B [auth W], C [auth X], D [auth K], E [auth L], F [auth Q], G [auth N], H [auth D], I [auth P], J [auth T], K [auth S], L [auth O], M [auth R], N [auth M]	OPM	Transmembrane	Alpha-helical polytopic	Ammonia/urea transporters/Na+ exporter	Ammonia transporter Amt

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth W], C [auth X], D [auth K], E [auth L] A, B [auth W], C [auth X], D [auth K], E [auth L], F [auth Q], G [auth N], H [auth D], I [auth P], J [auth T], K [auth S], L [auth O], M [auth R], N [auth M]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B [auth W], C [auth X], D [auth K], E [auth L] A, B [auth W], C [auth X], D [auth K], E [auth L], F [auth Q], G [auth N], H [auth D], I [auth P], J [auth T], K [auth S], L [auth O], M [auth R], N [auth M]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Solute Carrier Family 4 (anion exchanger)	Erythrocyte Band 3 anion exchanger complex. Band 3-Glycophorin A complex, outward facing