8H6S | pdb_00008h6s

Structure of acyltransferase VinK in complex with the loading acyl carrier protein of vicenistatin PKS

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EUF08355	e8h6sA2	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: EUF08355	ECOD (1.6)
A	Acyl_transf_1_1st	e8h6sA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
B	EUF08355	e8h6sB1	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: EUF08355	ECOD (1.6)
B	Acyl_transf_1_1st	e8h6sB2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
C	PP-binding	e8h6sC1	A: alpha bundles	X: ACP-like	H: Acyl-carrier protein (ACP) (From Topology)	T: Acyl-carrier protein (ACP)	F: PP-binding	ECOD (1.6)
D	PP-binding	e8h6sD1	A: alpha bundles	X: ACP-like	H: Acyl-carrier protein (ACP) (From Topology)	T: Acyl-carrier protein (ACP)	F: PP-binding	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21124	VinK acyltransferase small domain (VinK_C)	VinK acyltransferase small domain	This family includes the VinK acyltransferase. VinK transfers a dipeptide group between two ACPs, VinL and VinP1LdACP, in vicenistatin biosynthesis [1]. This entry represents the small C-terminal domain [1]. VinK has two conserved catalytic residues, ...	This family includes the VinK acyltransferase. VinK transfers a dipeptide group between two ACPs, VinL and VinP1LdACP, in vicenistatin biosynthesis [1]. This entry represents the small C-terminal domain [1]. VinK has two conserved catalytic residues, Ser-106 and His-216, at the interface between the large domain and small domain [1].	Domain
C, D	PF00550	Phosphopantetheine attachment site (PP-binding)	Phosphopantetheine attachment site	A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes memb ...	A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Malonyl-CoA-[acyl-carrier-protein] transacylase	malonyltransferase activity acyltransferase activity [acyl-carrier-protein] S-malonyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity S-acyltransferase activity catalytic activity S-malonyltransferase activity cation binding ion binding binding metal ion binding small molecule binding	fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process	-
C, D	Polyketide synthase modules 1-3	oxidoreductase activity catalytic activity vitamin binding amide binding modified amino acid binding binding phosphopantetheine binding small molecule binding acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity fatty acid synthase activity cation binding oxidoreductase activity catalytic activity vitamin binding amide binding modified amino acid binding binding phosphopantetheine binding small molecule binding acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity fatty acid synthase activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding	antibiotic metabolic process biosynthetic process metabolic process cellular process antibiotic biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process antibiotic metabolic process biosynthetic process metabolic process cellular process antibiotic biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	Homologous Superfamily
A, B	IPR001227	Acyl transferase domain superfamily	Homologous Superfamily
A, B	IPR050858	Malonyl CoA-ACP Transacylase/Polyketide Synthase FabD	Family
A, B	IPR049416	Malonyl-CoA-[acyl-carrier-protein] transacylase, small domain	Domain
C, D	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	Homologous Superfamily
C, D	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
C, D	IPR006162	Phosphopantetheine attachment site	PTM
C, D	IPR013154	Alcohol dehydrogenase-like, N-terminal	Domain
C, D	IPR020807	Polyketide synthase, dehydratase domain	Domain
C, D	IPR049552	Polyketide synthase, dehydratase domain, N-terminal	Domain
C, D	IPR002364	Quinone oxidoreductase/zeta-crystallin, conserved site	Conserved Site
C, D	IPR049551	Polyketide synthase, dehydratase domain, C-terminal	Domain
C, D	IPR020843	Polyketide synthase, enoylreductase domain	Domain
C, D	IPR013968	Polyketide synthase, ketoreductase domain	Domain
C, D	IPR016036	Malonyl-CoA ACP transacylase, ACP-binding	Homologous Superfamily
C, D	IPR050091	Polyketide and Nonribosomal Peptide Biosynthesis Enzymes	Family
C, D	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
C, D	IPR036736	ACP-like superfamily	Homologous Superfamily
C, D	IPR014043	Acyl transferase domain	Domain
C, D	IPR032821	Polyketide synthase, C-terminal extension	Domain
C, D	IPR011032	GroES-like superfamily	Homologous Superfamily
C, D	IPR009081	Phosphopantetheine binding ACP domain	Domain
C, D	IPR020806	Polyketide synthase-like, phosphopantetheine-binding domain	Domain
C, D	IPR016039	Thiolase-like	Homologous Superfamily
C, D	IPR001227	Acyl transferase domain superfamily	Homologous Superfamily
C, D	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
C, D	IPR018201	Beta-ketoacyl synthase, active site	Active Site
C, D	IPR014030	Beta-ketoacyl synthase-like, N-terminal	Domain
C, D	IPR042104	Polyketide synthase, dehydratase domain superfamily	Homologous Superfamily
C, D	IPR049900	Polyketide/metazoan fatty acid synthase, dehydratase domain	Domain
C, D	IPR055123	Polyketide synthase extender module SpnB-like, Rossmann fold domain	Domain