Annotations: 8Q8K

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8039556	3000116	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8039556	3000116	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00514	Armadillo/beta-catenin-like repeat (Arm)	Armadillo/beta-catenin-like repeat	-	Repeat
A, B	PF16186	Atypical Arm repeat (Arm_3)	Atypical Arm repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Importin subunit alpha-1	transcription factor binding protein binding binding DNA-binding transcription factor binding nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity	regulation of biological process regulation of viral process regulation of viral life cycle positive regulation of viral life cycle positive regulation of viral process viral process biological regulation positive regulation of biological process viral life cycle cellular response to stimulus regulation of cellular process response to stimulus signaling cell-cell signaling regulation of biological process regulation of viral process regulation of viral life cycle positive regulation of viral life cycle positive regulation of viral process viral process biological regulation positive regulation of biological process viral life cycle cellular response to stimulus regulation of cellular process response to stimulus signaling cell-cell signaling postsynaptic signal transduction cell communication synaptic signaling cellular process postsynapse to nucleus signaling pathway signal transduction protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport viral penetration into host nucleus entry of viral genome into host nucleus through nuclear pore complex via importin intracellular transport of virus transport of virus	host cellular component cellular anatomical structure host cell intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule protein-containing complex host cellular component cellular anatomical structure host cell intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule protein-containing complex nucleocytoplasmic transport complex NLS-dependent protein nuclear import complex cytosol postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction asymmetric synapse membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen glutamatergic synapse
C, D	Large T antigen	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity isomerase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides cation binding metal ion binding	nucleobase-containing compound metabolic process DNA replication metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated suppression of host JAK-STAT cascade symbiont-mediated perturbation of host process nucleobase-containing compound metabolic process DNA replication metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated suppression of host JAK-STAT cascade symbiont-mediated perturbation of host process symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host defense response viral process modulation by virus of host process virus-mediated perturbation of host defense response modulation by virus of host cellular process symbiont-mediated perturbation of host cell cycle progression symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint response to host defenses response to stimulus response to other organism symbiont-mediated perturbation of host immune response symbiont-mediated perturbation of host defenses response to defenses of other organism response to external stimulus response to biotic stimulus symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated suppression of host type I interferon-mediated signaling pathway	host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002652	Importin-alpha, importin-beta-binding domain	Domain
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR000225	Armadillo	Repeat
A, B	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B	IPR024931	Importin subunit alpha	Family
A, B	IPR036975	Importin-alpha, importin-beta-binding domain superfamily	Homologous Superfamily
A, B	IPR032413	Atypical Arm repeat	Repeat
C, D	IPR017910	Zinc finger, large T-antigen D1-type	Domain
C, D	IPR003133	T antigen, Ori-binding	Domain
C, D	IPR037102	Zinc finger, large T-antigen D1 domain superfamily	Homologous Superfamily
C, D	IPR036869	Chaperone J-domain superfamily	Homologous Superfamily
C, D	IPR014015	Helicase, superfamily 3, DNA virus	Domain
C, D	IPR001623	DnaJ domain	Domain
C, D	IPR016392	Large T antigen, polyomaviridae	Family
C, D	IPR010932	Large T antigen, polyomavirus, C-terminal	Domain
C, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.