Annotations: 8TUV

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8039556	3000116	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00514	Armadillo/beta-catenin-like repeat (Arm)	Armadillo/beta-catenin-like repeat	-	Repeat
A	PF16186	Atypical Arm repeat (Arm_3)	Atypical Arm repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Importin subunit alpha-1	transcription factor binding protein binding binding DNA-binding transcription factor binding nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity	regulation of biological process regulation of viral process regulation of viral life cycle positive regulation of viral life cycle positive regulation of viral process viral process biological regulation positive regulation of biological process viral life cycle cellular response to stimulus regulation of cellular process response to stimulus signaling cell-cell signaling regulation of biological process regulation of viral process regulation of viral life cycle positive regulation of viral life cycle positive regulation of viral process viral process biological regulation positive regulation of biological process viral life cycle cellular response to stimulus regulation of cellular process response to stimulus signaling cell-cell signaling postsynaptic signal transduction cell communication synaptic signaling cellular process postsynapse to nucleus signaling pathway signal transduction protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport viral penetration into host nucleus entry of viral genome into host nucleus through nuclear pore complex via importin intracellular transport of virus transport of virus	host cellular component cellular anatomical structure host cell intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule protein-containing complex host cellular component cellular anatomical structure host cell intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule protein-containing complex nucleocytoplasmic transport complex NLS-dependent protein nuclear import complex cytosol postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction asymmetric synapse membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen glutamatergic synapse
B	SER-ARG-LYS-ARG-LYS-PHE	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity hydrolase activity cation binding metal ion binding	nucleobase-containing compound metabolic process DNA replication metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process	host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle
C	30S ribosomal protein S11	RNA binding small ribosomal subunit rRNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome	biosynthetic process cytoplasmic translation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit intracellular membraneless organelle intracellular organelle ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex membraneless organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit intracellular membraneless organelle intracellular organelle ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex membraneless organelle ribosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002652	Importin-alpha, importin-beta-binding domain	Domain
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR000225	Armadillo	Repeat
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR024931	Importin subunit alpha	Family
A	IPR036975	Importin-alpha, importin-beta-binding domain superfamily	Homologous Superfamily
A	IPR032413	Atypical Arm repeat	Repeat
B	IPR017910	Zinc finger, large T-antigen D1-type	Domain
B	IPR003133	T antigen, Ori-binding	Domain
B	IPR037102	Zinc finger, large T-antigen D1 domain superfamily	Homologous Superfamily
B	IPR036869	Chaperone J-domain superfamily	Homologous Superfamily
B	IPR014015	Helicase, superfamily 3, DNA virus	Domain
B	IPR010932	Large T antigen, polyomavirus, C-terminal	Domain
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C	IPR001971	Small ribosomal subunit protein uS11	Family
C	IPR019981	Small ribosomal subunit protein uS11, bacterial-type	Family
C	IPR036967	Small ribosomal subunit protein uS11 superfamily	Homologous Superfamily
C	IPR018102	Small ribosomal subunit protein uS11, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.