8VHP

Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to CDP and two molecules of ATP

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	R1 subunit of ribonucleotide reductase, N-terminal domain	8038325	3000927	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PFL-like glycyl radical enzymes	8043875	3001069	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	R1 subunit of ribonucleotide reductase, N-terminal domain	8038325	3000927	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PFL-like glycyl radical enzymes	8043875	3001069	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	R1 subunit of ribonucleotide reductase, N-terminal domain	8038325	3000927	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PFL-like glycyl radical enzymes	8043875	3001069	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PFL-like glycyl radical enzymes	8043875	3001069	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	R1 subunit of ribonucleotide reductase, N-terminal domain	8038325	3000927	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	R1 subunit of ribonucleotide reductase, N-terminal domain	8038325	3000927	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PFL-like glycyl radical enzymes	8043875	3001069	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	R1 subunit of ribonucleotide reductase, N-terminal domain	8038325	3000927	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PFL-like glycyl radical enzymes	8043875	3001069	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	R1 subunit of ribonucleotide reductase, N-terminal domain	8038325	3000927	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	PFL-like glycyl radical enzymes	8043875	3001069	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	PFL-like glycyl radical enzymes	8043875	3001069	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	R1 subunit of ribonucleotide reductase, N-terminal domain	8038325	3000927	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF02867	Ribonucleotide reductase, barrel domain (Ribonuc_red_lgC)	Ribonucleotide reductase, barrel domain	-	Family
A, B, C, D, E A, B, C, D, E, F, G, H	PF00317	Ribonucleotide reductase, all-alpha domain (Ribonuc_red_lgN)	Ribonucleotide reductase, all-alpha domain	-	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	PF03477	ATP cone domain (ATP-cone)	ATP cone domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Ribonucleoside-diphosphate reductase 1 subunit alpha	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ribonucleoside-diphosphate reductase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor catalytic activity protein folding chaperone identical protein binding protein binding	nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process small molecule metabolic process metabolic process cellular process primary metabolic process nucleobase-containing small molecule interconversion nucleoside phosphate metabolic process nucleoside diphosphate metabolic process organophosphate metabolic process ribonucleoside diphosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process deoxyribose phosphate biosynthetic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process small molecule metabolic process metabolic process cellular process primary metabolic process nucleobase-containing small molecule interconversion nucleoside phosphate metabolic process nucleoside diphosphate metabolic process organophosphate metabolic process ribonucleoside diphosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process deoxyribose phosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process deoxyribonucleotide biosynthetic process deoxyribonucleotide metabolic process carbohydrate derivative biosynthetic process 2'-deoxyribonucleotide metabolic process 2'-deoxyribonucleotide biosynthetic process nucleotide metabolic process deoxyribose phosphate metabolic process nucleobase-containing compound biosynthetic process biosynthetic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process	protein-containing complex cellular anatomical structure intracellular anatomical structure catalytic complex oxidoreductase complex cytoplasm cytosol ribonucleoside-diphosphate reductase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013509	Ribonucleotide reductase large subunit, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR005144	ATP-cone domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR008926	Ribonucleotide reductase R1 subunit, N-terminal	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013346	Ribonucleotide reductase, class I, alpha subunit, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000788	Ribonucleotide reductase large subunit, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR039718	Ribonucleoside-diphosphate reductase large subunit	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.