Annotations: 8WWY

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00498	FHA domain (FHA)	FHA domain	-	Family
B, D	PF00498	FHA domain (FHA)	FHA domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	TRAF-interacting protein with FHA domain-containing protein A	-	cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus intracellular signal transduction cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus intracellular signal transduction cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response cellular process activation of immune response positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction regulation of signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of cellular process regulation of signaling positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis cell surface receptor signaling pathway response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to tumor necrosis factor response to chemical tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus response to tumor necrosis factor	cellular anatomical structure intracellular anatomical structure cytoplasm
B, D	TRAF-interacting protein with FHA domain-containing protein B	enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity deubiquitinase activator activity peptidase activator activity	multicellular organismal process system process smooth muscle contraction phasic smooth muscle contraction muscle contraction peristalsis muscle system process digestion digestive system process mastication cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction multicellular organismal process system process smooth muscle contraction phasic smooth muscle contraction muscle contraction peristalsis muscle system process digestion digestive system process mastication cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction cellular process positive regulation of signaling developmental process cranial nerve formation cranial nerve morphogenesis nervous system development anatomical structure morphogenesis multicellular organism development nerve development vestibulocochlear nerve formation cranial nerve development vestibulocochlear nerve development vestibulocochlear nerve morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development system development regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process biological process involved in interspecies interaction between organisms response to lipid cellular response to lipopolysaccharide response to biotic stimulus lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to bacterium response to external biotic stimulus cell surface receptor signaling pathway response to other organism response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical cellular response to lipid response to molecule of bacterial origin nervous system process neuromuscular process neuromuscular process controlling balance negative regulation of relaxation of muscle regulation of system process negative regulation of biological process regulation of muscle system process relaxation of muscle regulation of multicellular organismal process regulation of relaxation of muscle negative regulation of multicellular organismal process regulation of localization regulation of body fluid levels transport negative regulation of saliva secretion negative regulation of transport localization negative regulation of secretion saliva secretion regulation of saliva secretion regulation of biological quality negative regulation of digestive system process secretion by tissue regulation of transport secretion regulation of digestive system process establishment of localization regulation of secretion body fluid secretion blastoderm segmentation zygotic determination of anterior/posterior axis, embryo embryonic pattern specification anterior/posterior pattern specification anterior/posterior axis specification, embryo segmentation pattern specification process embryo development regionalization tripartite regional subdivision embryonic axis specification anterior/posterior axis specification thorax and anterior abdomen determination axis specification behavior vocalization behavior learning or memory learned vocalization behavior learned vocalization behavior or vocal learning cognition genitalia development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction reproductive structure development animal organ morphogenesis genitalia morphogenesis trigeminal nerve development muscle structure development regulation of muscle organ development regulation of developmental process muscle organ development ear morphogenesis embryonic organ morphogenesis ear development sensory organ development embryonic morphogenesis sensory organ morphogenesis inner ear development cochlea development inner ear morphogenesis cochlea morphogenesis embryonic organ development craniofacial suture morphogenesis skeletal system development cranial skeletal system development skeletal system morphogenesis bone morphogenesis bone development intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator regulation of cellular response to stress cellular response to chemical stress regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway cellular response to environmental stimulus regulation of response to osmotic stress regulation of cellular response to osmotic stress cellular response to stress response to stress regulation of response to stress regulation of signal transduction by p53 class mediator intrinsic apoptotic signaling pathway response to osmotic stress regulation of apoptotic process regulation of intrinsic apoptotic signaling pathway in response to osmotic stress regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator signal transduction by p53 class mediator cellular response to osmotic stress cell death apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to osmotic stress response to abiotic stimulus intrinsic apoptotic signaling pathway by p53 class mediator cellular response to abiotic stimulus apoptotic process regulation of intrinsic apoptotic signaling pathway by p53 class mediator programmed cell death regulation of apoptotic signaling pathway cellular developmental process hemopoiesis cell differentiation cell development hematopoietic progenitor cell differentiation response to auditory stimulus auditory behavior response to mechanical stimulus mechanosensory behavior hard palate morphogenesis regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus pattern recognition receptor signaling pathway regulation of response to external stimulus toll-like receptor signaling pathway immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response innate immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of innate immune response defense response immune response regulation of innate immune response defense response to symbiont immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response myeloid cell differentiation	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
A, C	IPR000253	Forkhead-associated (FHA) domain	Domain
A, C	IPR033621	TRAF-interacting protein with FHA domain-containing protein	Family
B, D	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
B, D	IPR000253	Forkhead-associated (FHA) domain	Domain
B, D	IPR033621	TRAF-interacting protein with FHA domain-containing protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.