9C9Q | pdb_00009c9q

Crystal structure of Chaetomium thermophilum Gcn2 HisRS-like domain

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13393	Histidyl-tRNA synthetase (tRNA-synt_His)	Histidyl-tRNA synthetase	This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.	Domain
A, B	PF12745	Anticodon binding domain of tRNAs (HGTP_anticodon2)	Anticodon binding domain of tRNAs	This is an HGTP_anticodon binding domain, found largely on Gcn2 proteins which bind tRNA to down regulate translation in certain stress situations.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	non-specific serine/threonine protein kinase	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity histone H3S57 kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H3 kinase activity histone modifying activity catalytic activity histone kinase activity histone H2AS121 kinase activity histone H2A kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity histone H3S57 kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H3 kinase activity histone modifying activity catalytic activity histone kinase activity histone H2AS121 kinase activity histone H2A kinase activity Rho-dependent protein serine/threonine kinase activity AMP-activated protein kinase activity histone H2AT120 kinase activity DNA-dependent protein kinase activity histone H3T45 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity eukaryotic translation initiation factor 2alpha kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T11 kinase activity histone H3S28 kinase activity histone H3T6 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2B kinase activity histone H2BS36 kinase activity histone H3T3 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity histone H2BS14 kinase activity	regulation of cell cycle phase transition regulation of cellular process sexual reproduction regulation of reproductive process reproductive process negative regulation of biological process negative regulation of cell cycle cell cycle phase transition meiotic cell cycle process negative regulation of cellular process G2/MI transition of meiotic cell cycle negative regulation of cell cycle phase transition cell cycle regulation of cell cycle regulation of cell cycle phase transition regulation of cellular process sexual reproduction regulation of reproductive process reproductive process negative regulation of biological process negative regulation of cell cycle cell cycle phase transition meiotic cell cycle process negative regulation of cellular process G2/MI transition of meiotic cell cycle negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process cell cycle G2/M phase transition regulation of biological process regulation of meiotic cell cycle regulation of cell cycle process meiotic cell cycle regulation of meiotic cell cycle phase transition biological regulation regulation of cell cycle G2/M phase transition negative regulation of G2/MI transition of meiotic cell cycle negative regulation of cell cycle process meiotic cell cycle phase transition meiosis I cell cycle process negative regulation of reproductive process negative regulation of cell cycle G2/M phase transition cellular process negative regulation of meiotic cell cycle phase transition negative regulation of meiotic cell cycle regulation of G2/MI transition of meiotic cell cycle cellular response to stimulus DNA damage checkpoint signaling response to stimulus signaling intracellular signal transduction cell communication cellular response to stress response to stress signal transduction DNA integrity checkpoint signaling cell cycle checkpoint signaling DNA damage response signal transduction in response to DNA damage	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B	IPR045864	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)	Homologous Superfamily
A, B	IPR016135	Ubiquitin-conjugating enzyme/RWD-like	Homologous Superfamily
A, B	IPR041715	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain	Domain
A, B	IPR050339	Cell Cycle and Stress Response Kinase	Family
A, B	IPR000719	Protein kinase domain	Domain
A, B	IPR006575	RWD domain	Domain
A, B	IPR036621	Anticodon-binding domain superfamily	Homologous Superfamily
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR016255	eIF-2-alpha kinase Gcn2	Family
A, B	IPR024435	Histidyl tRNA synthetase-related domain	Domain
A, B	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.