4PZ

4-methyl-1H-pyrazole

Created: 2008-08-19
Last modified:  2011-06-04

Help

Find related ligands:

Chemical Details

Formal Charge0
Atom Count12
Chiral Atom Count0
Bond Count12
Aromatic Bond Count5
2D diagram of 4PZ
Toggle HydrogenToggle Labels

Chemical Component Summary

Name4-methyl-1H-pyrazole
Systematic Name (OpenEye OEToolkits)4-methyl-1H-pyrazole
FormulaC4 H6 N2
Molecular Weight82.104
TypeNON-POLYMER

Chemical Descriptors

TypeProgram Version Descriptor
SMILESACDLabs10.04n1cc(cn1)C
SMILESCACTVS3.341Cc1c[nH]nc1
SMILESOpenEye OEToolkits1.5.0Cc1c[nH]nc1
Canonical SMILESCACTVS3.341 Cc1c[nH]nc1
Canonical SMILESOpenEye OEToolkits1.5.0 Cc1c[nH]nc1
InChIInChI1.03 InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
InChIKeyInChI1.03 RIKMMFOAQPJVMX-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank IDDB01213 
NameFomepizole
Groups
  • approved
  • vet_approved
DescriptionFomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
Synonyms
  • Fomepizole sulfate
  • Fomepizolum
  • Fomepizol
  • 4-methylpyrazol
  • 4-methylpyrazole
Brand Names
  • Fomepizole
  • Antizol
  • Fomepizole for Injection
IndicationAntizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis
Categories
  • Antidotes
  • Compounds used in a research, industrial, or household setting
  • Cytochrome P-450 CYP2A6 Inhibitors
  • Cytochrome P-450 CYP2A6 Inhibitors (strength unknown)
  • Cytochrome P-450 CYP2E1 Inducers
ATC-CodeV03AB34
CAS number7554-65-6

Drug Targets

NameTarget SequencePharmacological ActionActions
Alcohol dehydrogenase 1AMSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTD...unknowninhibitor
Alcohol dehydrogenase 1BMSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTD...unknowninhibitor
Alcohol dehydrogenase 1CMSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSD...unknowninhibitor
CatalaseMADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPL...unknowninhibitor
Cytochrome P450 2A6MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...unknowninhibitor
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL1308
PubChem 3406
ChEMBL CHEMBL1308
ChEBI CHEBI:5141
CCDC/CSD HOQHUQ
COD 7051396