Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder.[L12885] It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).[L12885] Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively. Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.[L12885] Risperidone binds with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug's binding affinity to D2 receptors, and carries lesser activity at several off-targets which may responsible for some of its undesirable effects.[L12885]
Synonyms
Rispéridone
Risperidonum
Risperidone tartrate
Risperidona
Risperidone
Brand Names
Risperidone - 0.25
Rykindo extended-release microspheres
PMS-risperidone ODT
Dom-risperidone ODT
PHL-risperidone
Taro-risperidone
Risperidone - 3
Mint-risperidon
Mylan-risperidone ODT
Risperidone - 1
Riva-risperidone
Risperidone
Teva-risperidone
Mylan-risperidone
Ava-risperidone
Risperidone - 0.5
Ran-risperidone
Act Risperidone
Okedi
Perseris
Risperidone - 4
Uzedy
Risperidone - 2
Truemed Group LLC
Risperdal Consta
Ag-risperidone
Dom-risperidone
Risperidone Tablets
Nu-risperidone
Risperdal M-tab
Risperidone M-TAB
Q-risperidone
Apo-risperidone
Mar-risperidone
Ratio-risperidone
Jamp-risperidone
Sandoz Risperidone
Risperdal
PMS-risperidone
Pro-risperidone
Risperdal Oral Solution
PHL-risperidone ODT
Ipg-risperidone
Indication
Risperidone is indicated for the treatment of schizophrenia [L12885,L44692,L46297] and irritability associated with autistic disorder.[L12885] It is also indicated as monotherapy, or adjunctly with lithium or valproic acid, for the treatment of acute mania or mixed episodes associated with bipolar I disorder.[L12885,L44692] Risperidone is additionally indicated in Canada for the short-term symptomatic management of aggression or psychotic symptoms in patients with severe dementia of the Alzheimer type unresponsive to nonpharmacological approaches.[L12906] Risperidone is also used off-label for a number of conditions including as an adjunct to antidepressants in treatment-resistant depression.[A177226]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
