ACH

ACETYLCHOLINE

Created:	1999-07-08
Last modified:	2024-09-27

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23 entries where ACH is found as a standalone ligand1 entries where ACH is covalently linked to polymer or other heterogen groups

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Chemical Details
Formal Charge	1
Atom Count	26
Chiral Atom Count	0
Bond Count	25
Aromatic Bond Count	0

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Chemical Component Summary
Name	ACETYLCHOLINE
Systematic Name (OpenEye OEToolkits)	2-acetyloxyethyl-trimethyl-azanium
Formula	C₇ H₁₆ N O₂
Molecular Weight	146.207
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(OCC[N+](C)(C)C)C
SMILES	CACTVS	3.341	CC(=O)OCC[N+](C)(C)C
SMILES	OpenEye OEToolkits	1.5.0	CC(=O)OCC[N+](C)(C)C
Canonical SMILES	CACTVS	3.341	CC(=O)OCC[N+](C)(C)C
Canonical SMILES	OpenEye OEToolkits	1.5.0	CC(=O)OCC[N+](C)(C)C
InChI	InChI	1.03	InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
InChIKey	InChI	1.03	OIPILFWXSMYKGL-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB03128
Name	Acetylcholine
Groups	approved investigational
Description	A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications.
Synonyms	Acetylcholine chloride ACh Choline acetate Acetylcholine O-Acetylcholine
Brand Names	Miogan Pws 20mg/vial Miochol E Miochol E Acetylcholine Chloride Oph Soln Miochol-E
Indication	Used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.
Categories	Amines Antiglaucoma Preparations and Miotics Biogenic Amines Cardiovascular Agents Cholinergic Agents Cholinergic Agonists Cholinergic Receptor Agonist Cholinesterase substrates Miotics Neurotransmitter Agents OCT1 substrates Ophthalmologicals Parasympathomimetics Sensory Organs Vasodilating Agents
ATC-Code	S01EB09
CAS number	51-84-3

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Muscarinic acetylcholine receptor M1	MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISF...	unknown
Muscarinic acetylcholine receptor M2	MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKV...	unknown
Muscarinic acetylcholine receptor M3	MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFS...	unknown
Muscarinic acetylcholine receptor M4	MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGN...	unknown
Neuronal acetylcholine receptor subunit alpha-7	MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQP...	unknown
Acetylcholinesterase	MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG...	unknown	substrate
Cholinesterase	MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFG...	unknown	substrate
Solute carrier family 22 member 5	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682