CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

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is present as a standalone ligand in 9 entries

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Identifiers	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER
Isomeric SMILES	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

Drug Info: DrugBank

DrugBank ID	DB00257
Name	Clotrimazole
Groups	vet_approved approved
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	Clotrimazol 1-(o-Chloro-α,α-diphenylbenzyl)imidazole Clotrimazolum 1-(α-(2-Chlorophenyl)benzhydryl)imidazole Clotrimazole 1-(o-Chlorotrityl)imidazole 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole
Brand Names	Clotrimazole Antifungal Jock-eze Clotrimazole Vaginal 6 Blossom Pharmaceuticals Antifungal Smooth Gator Fungus Eliminator FungaZoil Advanced Canesten 200 Mg Vaginal Inserts Pedesil Gehwol Fusskraft Nail and Skin Protection Publix athletic foot Canesten 3 Day Internal Cream Anti-Fungal Canesoral Combi Taro-clotrimazole/betamethasone Dipropionate Terrasil Antifungal Cream Maximum Strength Votriza-AL Micotrin AC Major Clotrimazole Canesten Combi 1 Day Comfortab + Extra Strength External Cream Athlete Foot Cream with Clotrimazole Terrasil Rapid-Clear Anti-Fungal Athletes Foot Antifungal Antifungal Canesten External Antifungal Cream TheraPlus Plus Protective and Moisturizing Skin Quality Choice Clotrimazole Akin Anti-fungal Canesten Combi-pak 1 Day Therapy Scheinpharm Clotrimazole 1% Clotrimazole External Antifungal Cream Cura Hongo Antifungal sunmark Clotrimazole 3 Lotrimin Clotrimazol Lotrisone Fastrin Anti - Fungal Skin Care Clotrimazole/Betameth Walgreens Clotrimazole CVS Pharmacy ITCH RELIEF ANTIFUNGAL Shield and Protect Anti-Fungal CVS Clotrimazole Maximum Strength Anti-Fungal Cream Athlete s Foot Afac Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM CAREONE Clotrimazole Meijer Athletes Foot Cream AF Terrasil Foot and Nail Anti-Fungal Maximum Strength Rugby Clotrimazole Antifungal Cream Clotrimaderm Vaginal 6 Thera plus Antifungal Clotrimazole MakeSense Occulus Skin Hydrating Topical Foam CLO-1 Skin Repair Gyne-Lotrimin 3 Myclo Tab 100mg Terrasil Jock Itch Treatment Maximum Strength SoundBody Clotrimazole Antifungal Fungicure Pumpspray Au Kah Chuen Antifungal Leader Athletes Foot Clotrimazole Mycozyl AC First Aid Research Antifungal Cream 1oz Soothing Antifungal Cream Terrasil Ringworm Treatment MAX Myclo-derm Solution 1% Aspiera Anti-Fungal Canesten 1 Day Internal Cream Canesten Liq 1% Canesten Extra Strength External Antifungal Cream Antifungal Cream Canesten 1 Vaginal Tablet Combi-pak Family Care Antifungal Myclo-derm Cream 1% Antifungal Foot Protective Nail and skin Smart Sense Athletes Foot Antifungal Clotrimaderm Vaginal 3 Zapotol Clotrimazole Equate Jock Itch Terrasil Anti-Fungal Treatment MAX Kleer-Plex Fungistat Athlete Foot Cure Canesten 3 Vaginal Tablet Combi-pak Olp Clotrimazole Clotrimaderm-fluconazole Combi-pack Equaline Antifungal Cream Family Care Clotrimazole Anti-Fungal Cream 1% Alevazol SIMPLY VITAL Antifungal Cream Myclo Crm 10mg Desenex meijer Clotrimazole 3 CVS Pharmacy Clotrimazole 3 Jock Itch Canesten Combi 1 Day Lotrimin Antifungal TerrasilMed ANTIFUNGAL Ciclomazole Clotrimazol Dual Dermatin Antifungal Kerasal foot and toe Good Neighbor Pharmacy Clotrimazole Terrasil Tinea Treatment MAX Clotrimaderm Topical Solution 1% USP Myclo-gyne Inserts Jock Itch Antifungal Myclo Solution Clotrimazole-fluconazole Combi Fortinia Topcare Athletes Foot Canesten Crm 1% Vag Fortinia OF Gehwol med Foot Terbinafine HCl Chlortimazole and Tolnaftate Goodsense Athletes Foot Myclo-gyne Cream 1% Terrasil Athletes Foot AntiFungal Treatment Max JiDeSheng CVS Antifungal Ringworm Fungistat Max Terrasil Foot and Nail Anti-Fungal Good Sense Athletes Foot antifungal Hua Tuo Xian Gao Antifungal Good Neighbor Pharmacy Clotrimazole 3 Canesten 6 Day Internal Cream CAREALL Clotrimazole PRO-EX Anti Fungal Shopko Athletes Foot Femmesil Family Care Clotrimazole Antifungal S-Cream CLOTRIMAZOLE Cream 1% Terrasil Tinea Treatment Maximum Strength Canesoral Combi 1 Day Kleer-Plex Fungistat Fungus Cure Leader Clotrimazole Anti-Fungal Lotriderm First Aid Research Antifungal .5oz CVSHealth Antifungal Walgreens Jock Itch Atopalm Clotrimazole Antifungal ClotrimazOil Antifungal Dynarex Antifungal Fungicure Manicure Pedicure Anti Fungal Signature Care Jock Itch Rugby Antifungal Clotrimazole Jock Itch Clotrimazole Antifungal Clotrimazole Topical Equaline Clotrimazole Antifungal Myclo Crm 50mg Clotrimaderm Topical Neo-zol Cream 1% Quality Choice Athletes Foot Terrasil JockItch Treatment Maximum Strength TopCare Clotrimazole 3 PerfectHeal Antifungal Canesten 1% Topical Cream Clotrimaderm External Cream Canesten Combi 3 Day Walgreens Clotrimazole Antifungal Gehwol Nail Protection Pen Forticept Antifungal Cooling Our Family Athletes Foot WinCo Foods Antifungal Canesten Crm 1% Top Clotrimazole External Cream Fungicure Manicure Pedicure Extra Strength Clotrimazole Extra Fort -fluconazole Combi Ringworm Sunmark Clotrimazole Athletes Foot TopCare Antifungal Clotrimazole and Betamethasone Dipropionate TM-Clotrimazole Rexall Jock Itch Meijer Clotrimazole Antifungal Silka Ringworm Clotrimazole Topical Solution 1% Canesten External Cream Canesten Combi 1 Day Internal + External Creams Rite Aid antifungal ringworm Signature Care Athletes Foot Up and Up Athletes Foot Botanimedix TineaRX Antifungal Drying Emulsion Kroger ATHLETES FOOT Terrasil Anti-fungal Treatment Lucky SuperSoft Athletes Foot Best Choice Clotrimazole Mycelex Terrasil Anti-Fungal Treatment Fungicure Liquid Gel Forticept Antifungal Foot Gel Canesten 2% Vaginal Cream Gyne-Lotrimin 7 Dr Sheffield Athletes Foot Live Better Antifungal Betamethasone Clotrimazole Clotrimazole 1% Kroger Jock Itch Footlogix Pedesil Maximum Strength Family Wellness Antifungal Canesten 100mg Vaginal Inserts Budpak Antifungal Clotrimazole 1MED Clotrimazole 1% Antifungal Cream DermacinRx Therazole Pak HEB Antifungal Neo-zol Vaginal Cream 2% Canesten Comfortab 3 Signature Care Antifungal Family Wellness Clotrimazole 1 Anti Fungal Cream Foot Care Clotrimazole Western Family Athletes Foot PMS-clotrimazole-betamethasone Canesten V Walgreens Clotrimazole 3 Clotrimazole Extra Strength External Antifungal Cream Rexall Athletes Foot Clotrimazole Cream 1% Terrasil Jock-Itch Treatment MAX Clotrimazole Athletes Foot Anti Fungal Fungicure Intensive Clotrimazole Topical Solution USP, 1% Lakesia Clotrimazole Jock Itch Clotrimazole Footlogix Intensive Care Diabetic Formula Healthy Accents Antifungal Neo-zol Vaginal Cream 1% Jock Itch Cream with Clotrimazole Antifungal Canesten Comfortab 1 Aptrimazole 1.0% Antifungal Cream Exchange Select Atheletes foot UpandUp Clotrimazole Oheal Ringworm Cream Fungicure Manicure Pedicure Liquid Gel Gerlasan Hand Canesten Vaginal Inserts 100mg Clotrimazole 1% Athletes Foot Forticept Antifungal Foot Cream Hua Tuo Xian Gao meijer Athletes Foot Oheal Manuka Honey Eczema Cream ShopRite antifungal Up and Up Jock Itch Relief WinCo Antifungal Canesten 1% Topical Solution Clotrimazole Vaginal 3 Clotrimazole 1% Topical Antifungal Cream Astonea Clotrimazole 1% Athletes Foot
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Cytochrome P450 51	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
P-glycoprotein 1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682