CPT

Cisplatin

Created: 1999-07-08
Last modified:  2021-03-01

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Chemical Details

Formal Charge0
Atom Count11
Chiral Atom Count0
Bond Count10
Aromatic Bond Count0
2D diagram of CPT
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Chemical Component Summary

NameCisplatin
Synonymsdiammine(dichloro)platinum
Systematic Name (OpenEye OEToolkits)bis(chloranyl)-bis($l^{4}-azanyl)platinum
FormulaCl2 H6 N2 Pt
Molecular Weight300.045
TypeNON-POLYMER

Chemical Descriptors

TypeProgram Version Descriptor
SMILESACDLabs12.01[Pt](N)(N)(Cl)Cl
SMILESCACTVS3.385N|[Pt](|N)(Cl)Cl
SMILESOpenEye OEToolkits1.7.6[NH3][Pt]([NH3])(Cl)Cl
Canonical SMILESCACTVS3.385 N|[Pt](|N)(Cl)Cl
Canonical SMILESOpenEye OEToolkits1.7.6 [NH3][Pt]([NH3])(Cl)Cl
InChIInChI1.03 InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChIKeyInChI1.03 LXZZYRPGZAFOLE-UHFFFAOYSA-L

Drug Info: DrugBank

DrugBank IDDB00515 
NameCisplatin
Groups approved
DescriptionCisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Synonyms
  • cis-diamminedichloroplatinum(II)
  • INT230-6 COMPONENT CISPLATIN
  • CIS-DIAMMINEDICHLOROPLATINUM
  • INT-230-6 COMPONENT CISPLATIN
  • (SP-4-2)-DIAMMINEDICHLOROPLATINUM
Brand Names
  • Cisplatin
  • Cisplatin Inj 0.5mg/ml
  • Cisplatin Inj 1mg/ml
  • Cisplatin Injection
  • PMS-cisplatin
IndicationFor the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Categories
  • Antineoplastic Agents
  • Antineoplastic and Immunomodulating Agents
  • BCRP/ABCG2 Substrates
  • Cardiotoxic antineoplastic agents
  • Chlorine Compounds
ATC-CodeL01XA01
CAS number15663-27-1

Drug Targets

NameTarget SequencePharmacological ActionActions
DNA-unknowncross-linking/alkylation
DNA-3-methyladenine glycosylaseMVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSD...unknown
Alpha-2-macroglobulinMGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVL...unknown
SerotransferrinMRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIP...unknown
Copper transport protein ATOX1MPKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDT...unknown
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem 5702198, 84691, 5460033
CCDC/CSD CUSRAJ