DrugBank ID DB00625 Name Efavirenz Groups Description Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission. Synonyms Éfavirenz Efavirenzum (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one (S)-6-chloro-4-(Cyclopropylethynyl)-1,4-dihydro-(S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one Efavirenz
6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one more Brand Names Teva-efavirenz Jamp-efavirenz Riva-efavirenz/emtricitabine/tenofovir Symfi Efavirenz, Emtricitabine and Tenofovir Disoproxil Fumarate
Efavirenz Teva Apo-efavirenz-emtricitabine-tenofovir Efavirenz, emtricitabine and tenofovir disoproxil fumarate PMS-efavirenz-emtricitabine-tenofovir Jamp Efavirenz/emtricitabine/tenofovir Disoproxil Fumarate Sustiva 100mg Teva-efavirenz/emtricitabine/tenofovir Symfi Lo Sandoz Efavirenz/emtricitabine/tenofovir Sustiva 50mg Sustiva Auro-efavirenz-emtricitabine-tenofovir Atripla Access Mylan-efavirenz Efavirenz/emtricitabine/ Tenofovir Disoproxil Zentiva Stocrin Sustiva 200mg Mylan-efavirenz/emtricitabine/tenofovir Disoproxil Fumarate Auro-efavirenz Atripla Efavirenz Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate Efavirenz/emtricita Bine/tenofovir Disoproxil Mylan Sustiva Tablets Efavirenz/emtricitabine/ Tenofovir Disoproxil Krka Efavirenz, Emtricitabine And Tenofovir Disoproxil Fumarate more Indication For use in combination treatment of HIV infection (AIDS) Categories Anti-Infective Agents Anti-Retroviral Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use
Antivirals used in combination for the treatment of HIV infections BSEP/ABCB11 Substrates Central Nervous System Depressants Cycloparaffins Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (moderate) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inducers Cytochrome P-450 CYP3A5 Inducers (moderate) Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (moderate) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Direct Acting Antivirals Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor Hydrocarbons, Acyclic Inducers of Drug Clearance Moderate Risk QTc-Prolonging Agents Non-Nucleoside Reverse Transcriptase Inhibitors Nonnucleoside Reverse Transcriptase Inhibitors Nucleic Acid Synthesis Inhibitors OCT1 inhibitors Oxazines QTc Prolonging Agents Reverse Transcriptase Inhibitors UGT1A1 Inducers more ATC-Code CAS number 154598-52-4 
