FME

N-FORMYLMETHIONINE

Created:	1999-07-08
Last modified:	2024-09-27

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17 entries where FME is found as a standalone ligand102 entries where FME is covalently linked to polymer or other heterogen groups 504 entries where FME is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	22
Chiral Atom Count	1
Bond Count	21
Aromatic Bond Count	0

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Chemical Component Summary
Name	N-FORMYLMETHIONINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-formamido-4-methylsulfanyl-butanoic acid
Formula	C₆ H₁₁ N O₃ S
Molecular Weight	177.221
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=CNC(C(=O)O)CCSC
SMILES	CACTVS	3.341	CSCC[CH](NC=O)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	CSCCC(C(=O)O)NC=O
Canonical SMILES	CACTVS	3.341	CSCC[C@H](NC=O)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	CSCC[C@@H](C(=O)O)NC=O
InChI	InChI	1.03	InChI=1S/C6H11NO3S/c1-11-3-2-5(6(9)10)7-4-8/h4-5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1
InChIKey	InChI	1.03	PYUSHNKNPOHWEZ-YFKPBYRVSA-N

Drug Info: DrugBank

DrugBank ID	DB04464
Name	N-Formylmethionine
Groups	experimental
Description	N-Formylmethionine is effective in the initiation of protein synthesis. The initiating methionine residue enters the ribosome as N-formylmethionyl tRNA. This process occurs in Escherichia coli and other bacteria as well as in the mitochondria of eucaryotic cells.
Synonyms	(2S)-2-(formylamino)-4-(methylthio)butanoic acid L-N-Formylmethionine Formyl-methionine N-Formylmethionine N-formyl-L-methionine
Categories	Amino Acids Amino Acids, Peptides, and Proteins Amino Acids, Sulfur Sulfur Compounds
CAS number	4289-98-9

Drug Targets

Name	Target Sequence	Pharmacological Action
Geranylgeranyl transferase type-2 subunit alpha	MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLE...	unknown
Geranylgeranyl transferase type-2 subunit beta	MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGI...	unknown
Photosynthetic reaction center cytochrome c subunit	MKQLIVNSVATVALASLVAGCFEPPPATTTQTGFRGLSMGEVLHPATVKA...	unknown
Reaction center protein H chain	MYHGALAQHLDIAQLVWYAQWLVIWTVVLLYLRREDRREGYPLVEPLGLV...	unknown
Reaction center protein L chain	MALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLI...	unknown
Reaction center protein M chain	MADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPI...	unknown
Light-harvesting protein B-800/820 alpha chain	MNQGKIWTVVPPAFGLPLMLGAVAITALLVHAAVLTHTTWYAAFLQGGVK...	unknown
Light-harvesting protein B-800/820 beta chain	AEVLTSEQAEELHKHVIDGTRVFLVIAAIAHFLAFTLTPWLH	unknown
Light-harvesting protein B-800/850 alpha chain	MNQGKIWTVVNPAIGIPALLGSVTVIAILVHLAILSHTTWFPAYWQGGVK...	unknown
Light-harvesting protein B-800/850 beta chain	ATLTAEQSEELHKYVIDGTRVFLGLALVAHFLAFSATPWLH	unknown
Antithrombin-III	MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMN...	unknown
Beta-2-microglobulin	MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGF...	unknown
NADH-ubiquinone oxidoreductase chain 1	MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFA...	unknown
HLA class I histocompatibility antigen, B-27 alpha chain	MRVTAPRTLLLLLWGAVALTETWAGSHSMRYFHTSVSRPGRGEPRFITVG...	unknown
Respiratory nitrate reductase 1 alpha chain	MSKFLDRFRYFKQKGETFADGHGQLLNTNRDWEDGYRQRWQHDKIVRSTH...	unknown
Respiratory nitrate reductase 1 beta chain	MKIRSQVGMVLNLDKCIGCHTCSVTCKNVWTSREGVEYAWFNNVETKPGQ...	unknown
Respiratory nitrate reductase 1 gamma chain	MQFLNMFFFDIYPYIAGAVFLIGSWLRYDYGQYTWRAASSQMLDRKGMNL...	unknown
Protein S100-G	MSTKKSPEELKRIFEKYAAKEGDPDQLSKDELKLLIQAEFPSLLKGPNTL...	unknown
Rubredoxin	MKKYVCTVCGYEYDPAEGDPDNGVKPGTSFDDLPADWVCPVCGAPKSEFE...	unknown
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVA...	unknown
Cytochrome c oxidase subunit 1	MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGN...	unknown
Cytochrome c oxidase subunit 2	MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKL...	unknown
Cytochrome c oxidase subunit 3	MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTN...	unknown
Cytochrome c oxidase subunit 5A, mitochondrial	MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDE...	unknown
Cytochrome c oxidase subunit 5B, mitochondrial	MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLERE...	unknown
Cytochrome c oxidase subunit 6C	MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYA...	unknown
Cytochrome c oxidase subunit 7B, mitochondrial	MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLASGATFCI...	unknown
Cytochrome c oxidase subunit 7C, mitochondrial	MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFA...	unknown
Cytochrome c oxidase subunit 8A, mitochondrial	MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVT...	unknown
Cytochrome c oxidase subunit 6A2, mitochondrial	MALPLRPLTRGLASAAKGGHGGAGARTWRLLTFVLALPSVALCTFNSYLH...	unknown
Cytochrome c oxidase subunit 6B1	MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGD...	unknown
Cytochrome c oxidase subunit 7A1, mitochondrial	MQALRVSQALIRSFSSTARNRFQNRVREKQKLFQEDNDIPLYLKGGIVDN...	unknown
Methionyl-tRNA formyltransferase	MSESLRIIFAGTPDFAARHLDALLSSGHNVVGVFTQPDRPAGRGKKLMPS...	unknown
Streptavidin	MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLG...	unknown
Protein S100-B	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKE...	unknown
Delta-hemolysin	MAQDIISTIGDLVKWIIDTVNKFTKK	unknown
Polyubiquitin-C	MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQL...	unknown
AtpH	MESNLTTAASVIAAALAVGIGSIGPGLGQGQAAGQAVEGIARQPEAEGKI...	unknown
Probable L-ascorbate-6-phosphate lactonase UlaG	MSKVKSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWL...	unknown
Immunoglobulin G-binding protein G	MEKEKKVKYFLRKSAFGLASVSAAFLVGSTVFAVDSPIEDTPIIRNGGEL...	unknown
Glutamate--cysteine ligase	MIPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGS...	unknown
Ribonuclease pancreatic	MALEKSLVRLLLLVLILLVLGWVQPSLGKESRAKKFQRQHMDSDSSPSSS...	unknown
Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial	MWPGILVGGARVASCRYPALGPRLAAHFPAQRPPQRTLQNGLALQRCLHA...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682