GSP
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Find entries where: GSP
is present as a standalone ligand in 133 entries
as a non-polymer is covalently linked to polymer or other heterogen groups 2 entries
Chemical Component Summary | |
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Name | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE |
Identifiers | [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] dihydroxyphosphinothioyl hydrogen phosphate |
Formula | C10 H16 N5 O13 P3 S |
Molecular Weight | 539.246 |
Type | NON-POLYMER |
Isomeric SMILES | c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=S)(O)O)O)O)N=C(NC2=O)N |
InChI | InChI=1S/C10H16N5O13P3S/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1 |
InChIKey | XOFLBQFBSOEHOG-UUOKFMHZSA-N |
Chemical Details | |
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Formal Charge | 0 |
Atom Count | 48 |
Chiral Atom Count | 6 |
Bond Count | 50 |
Aromatic Bond Count | 5 |
Drug Info: DrugBank
DrugBank ID | DB01864 |
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Name | 5'-Guanosine-Diphosphate-Monothiophosphate |
Groups | experimental |
Description | Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes. |
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Categories |
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CAS number | 37589-80-3 |
Drug Targets
Name | Target Sequence | Pharmacological Action | Actions |
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ADP-ribosylation factor 6 | MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVE... | unknown | |
Protein-glutamine gamma-glutamyltransferase E | MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGS... | unknown | |
Cell division protein FtsZ | MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMS... | unknown | |
Ras-related protein Rab-11A | MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFAT... | unknown |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
Resource Name | Reference |
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PubChem | 5280465, 135398675, 444121, 37792, 135450576 |
ChEMBL | CHEMBL1204628 |
ChEBI | CHEBI:43000 |