GTP

GUANOSINE-5'-TRIPHOSPHATE

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is present as a standalone ligand in 1,496 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 86 entries

is present in a polymer sequence 250 entries

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Chemical Component Summary
Name	GUANOSINE-5'-TRIPHOSPHATE
Identifiers	[[(2R,3S,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
Formula	C₁₀ H₁₆ N₅ O₁₄ P₃
Molecular Weight	523.18
Type	NON-POLYMER
Isomeric SMILES	c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
InChI	InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKey	XKMLYUALXHKNFT-UUOKFMHZSA-N

Chemical Details
Formal Charge	0
Atom Count	48
Chiral Atom Count	4
Bond Count	50
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB04137
Name	Guanosine-5'-Triphosphate
Groups	experimental
Description	Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety. [PubChem]
Synonyms	Guanosine-5'-Triphosphate
CAS number	86-01-1

Drug Targets

Name	Target Sequence	Pharmacological Action
RNA-directed RNA polymerase	MPRRAPAFPLSDIKAQMLFANNIKAQQASKRSFKEGAIETYEGLLSVDPR...	unknown
Uridine-cytidine kinase-like 1	MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRSNAESLDRLLPP...	unknown
GTPase HRas	MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET...	unknown
Genome polyprotein	MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRAPR...	unknown
Rho-related GTP-binding protein RhoE	MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPE...	unknown
Genome polyprotein	MELITNELLYKTYKQKPVGVEEPVYDQAGDPLFGERGAVHPQSTLKLPHK...	unknown
GTP-binding protein Rheb	MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVN...	unknown
GTP cyclohydrolase 1	MPSLSKEAALVHEALVARGLETPLRPPVHEMDNETRKSLIAGHMTEIMQL...	unknown
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1	MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGL...	unknown
Ras-related protein Rab-5A	MASRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQE...	unknown
Probable GTP-binding protein EngB	MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLINRKNLA...	unknown
mRNA-capping enzyme	MVPPTINTGKNITTERAVLTLNGLQIKLHKVVGESRDDIVAKMKDLAMDD...	unknown
Genome polyprotein	MGAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQDFSQDP...	unknown
ADP-ribosylation factor 1	MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIG...	unknown
Molybdenum cofactor guanylyltransferase	MNLMTTITGVVLAGGKARRMGGVDKGLLELNGKPLWQHVADALMTQLSHV...	unknown
Ornithine decarboxylase, inducible	MSSSLKIASTQEARQYFDTDRVVVDAVGSDFTDVGAVIAMDYETDVIDAA...	unknown
Glutamate dehydrogenase 1, mitochondrial	MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAAR...	unknown
Adenylosuccinate synthetase isozyme 1	MSGTRASNDRPPGAGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVV...	unknown
Ras-related protein Rap-2a	MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSP...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682