HCY

(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

Created:	2007-10-13
Last modified:	2021-03-01

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13 entries where HCY is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	56
Chiral Atom Count	7
Bond Count	59
Aromatic Bond Count	0

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Chemical Component Summary
Name	(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
Synonyms	CORTISOL
Systematic Name (OpenEye OEToolkits)	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Formula	C₂₁ H₃₀ O₅
Molecular Weight	362.46
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(CO)C3(O)C2(CC(O)C4C1(C(=CC(=O)CC1)CCC4C2CC3)C)C
SMILES	CACTVS	3.341	C[C]12CCC(=O)C=C1CC[CH]3[CH]4CC[C](O)(C(=O)CO)[C]4(C)C[CH](O)[CH]23
SMILES	OpenEye OEToolkits	1.5.0	CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Canonical SMILES	CACTVS	3.341	C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23
Canonical SMILES	OpenEye OEToolkits	1.5.0	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChI	InChI	1.03	InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey	InChI	1.03	JYGXADMDTFJGBT-VWUMJDOOSA-N

Drug Info: DrugBank

DrugBank ID	DB00741
Name	Hydrocortisone
Groups	approved vet_approved
Description	Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Synonyms	Hydrocortisone Hydrocortisonum Cortisol 11β-hydrocortisone (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione Hidrocortisona 11beta-hydrocortisone Reichstein's substance M 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione Kendall's compound F 17-Hydroxycorticosterone 4-pregnen-11β,17α,21-triol-3,20-dione
Brand Names	Equaline Anti Itch Hydroxym Welly Human Repair Kit Gelmicin Hydrocortisone with Aloe Topcare Hydrocortisone Dermoscribe Ichybum HeXashield Anti Itch Cream with Healing Aloe Smart Sense Anti Itch Hydrocort Family Wellness Hydrocortisone Glytone soothe calming Emo Cort Sol 2.5% USP Dermoscribe Seborrheic Dermatitis Hydrocortisone With Aloe Vioform + Hydrocortisone Sandoz Cortimyxin Western Family HydroCortisone Plus 12 Moisturizers Pramoxine-HC Cortizone 10 Overnight Itch Relief WINCO Hydrocortisone Sandoz Hydrocortisone Hydrocortisone D Pediadermics Eczema 2 Cortomycin Cvs Hydrocortisone With Aloe Anti-itch Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4% Bioelements Immediate Comfort Hydrocortisone Harris Teeter Anti-Itch with Aloe Good Neighbor Pharmacy Anti Itch Smart Sense Anti Itch Maximum Strength Theraplex AIM Anti-Itch Moisturizing Cream glo SKIN BEAUTY Remedy Gel Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05% Sunmark Hydrocortisone with Aloe Maximum Strength Hydrocortisone Cream 0.5% USP Aveeno Hydrocortisone Anti-itch Cream Oti Rx Hydrocortisone 1% Hydrocortisone 1% in Absorbase Alkindi Hydrocortisone Plus 10 Moisturizers Ketocon TopCare Hydrocortisone Intensive Healing Formula Post Treatment Balm Natureplex Hydrocortisone Hydro Harris Teeter Anti-Itch Cooling Relief Proctosol-HC Odan-spor-HC Cortisone Cream Intensive Healing Barmicil Plus Quality Choice Anti-Itch Cortef Anti Itch Maximum Strength Maximum Strength Gold Bond Medicated Anti-itch Cream Intensive Formula Itch Stuff Hydrocortisone With Aloe Maximum Strength Cortaid 12-Hour Advanced Anti-Itch Avedana Hydrocortisone Cream with Aloe Hydrocortisone Butyrate Quality Choice Anti Itch with Aloe meijer Itch and Rash Relief Hydrocortisone with Aloe Maximum Strength Hydrocortisone Plus Moisturizing Aloe Aquanil HC Smart Sense Hydrocortisone Hydrocortisone 2.5% / Ketoconazole 2% Cortizone 10 Intensive Healing Feminine Itch Relief WinCo Maximum Strength Hydrocortisone Medi-First Plus Hydrocortisone Crane Safety Hydrocortisone Welly Excursion First Aid Kit FixMySkin Healing Balm Unflavored Proctozone-HC Hydrocortisone Iodoquinol Dr Lift Soothing Cream Neosporin Essentials Trial Pack Oto End 10 Shopko Maximum Strength Our Family Hydrocortisone with Aloe Live Better Hydrocortisone with Aloe Odan Proctomyxin HC ECOLAB Hydrocortisone Cream 999 Itch Relieving Loesch HC-10 ANTI-ITCH THERAPY HydroCortisone Intensive Healing Formula Eczema Skin Mushatts N9 Quality Choice Anti Itch HydrocortisoneLotion CVS Pharmacy Anti-itch TrueLipids Anti-Itch Barrier Barriere HC 1% Advanced Hydrocortisone Hydrocortisone Crm 1% Herb Street Anti-Itch Stick Texacort PS-2896 Hydrocortisone Cream 1%, 0.9g Meijer Maximum Strength Anti-itch Cream with Aloe HydroSkin Proctol Ointment Rugby Hydrocortisone With Aloe Piyanping antiitch Alkindi Sprinkle Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, CareOne Anti Itch Proctosedyl Suppositories TheraCare Maximum Strength 1% Hydrocortisone Hydrocortisone Regular Strength Cortizone 10 Anti-itch for Diabetics Skin Casporyn HC Quality Choice Maximum Strength Anti Itch Hydrocortisone, Iodoquinol Cipro FixMySkin Healing Balm Vanilla Fragrance Maximum-H Rite Aid Cortisone Soothe Rodan Fields Hydrocortisone Plus 12 Moisturizers Maximum Strength Anti Itch Cortisone 10 Overnight Creme Cortizone 10 for Psoriasis Hydrocortisone Anti-Itch TheraCare Hydrocortisone Cream Hydro Ear Selsun Blue Scalp Itch Treatment Hydrocortisone 1% with healing aloe Shopko Hydrocortisone Maximum Strength Maximum Strength Hydrocortisone Hydrocortisone Green Guard Maximum Strength Hydrocortisone FIRST Marys Mouthwash Compounding Thera plus Anti-itch with aloe Hydrocortisone BudPak Anti-Itch Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strength Anti itch Acetasol HC Family Wellness Max Strength 1 Hydrocortisone Cream Hydrocortisone Maximum Strength Cortisone maximum strength Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Scalpicin Scalp Itch Medication Maximum Strength NEOMYCIN and POLYMYXIN B SULFATES and HYDROCORTISONE Atopalm Maximum Strength Anti-Itch Quadrydern Ti-U-lac HC Lotion Cortate Crm 1% Up and Up Anti Itch Proctocream HC Monistat Complete Care Instant Itch Relief Good Neighbor Pharmacy Hydrocortisone Winco Maximum Strength Hydrocortisone Cortisone Hydrocortisone Plus 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Scarguard MD Physicians Formula Anti-Itch OLIVIA QUIDO FIRM and FADE I Petrocort Antipruritic Lip 21 Rite Aid anti-itch Cortizone 10 Water Resistant Preparation H Soothing Relief Anti-itch Hydrocortisone and Acetic Acid Up and Up Hydrocortisone Anti Itch Nizoral Scalp Itch Relief Caring Mills Hydrocortisone Shopko Hydrocortisone Freds Hydrocortisone Plus 12 Moisturizers Cipro HC Otic Suspension Pediaderm HC HydroSKIN Cortizone 10 Intensive Healing for Eczema Emo Cort Lotion 2.5% WinCo Foods Hydrocortisone Cream Intensive Healing Pediotic Theracort Rexall Hydrocortisone 1 Corti-Sav Meijer Anti Itch TopCare Hydrocortisone Plus 12 Moisturizers Healerz for Itches Emo Cort Cream 2.5% Hydrocortisone Continuous Texacort Solution 1% Rugby Hydroskin Cortizone 10 Feminine Itch Relief Duane Reade Premier Value Hydrocortisone Plus 12 Moisturizers Hydrocortisone anti-itch plus Cortizone 10 Itch Relief Massaging Rollerball Rexall Anti Itch Maximum Strength Relief Maximum Strength Cortisone Cream with Aloe Dermarest Dricort 0.5% Hydrocortisone Anti-itch Freds Hydrocortisone with Aloe Cortisone Plus Aloe Maximum Strength ATOPALM Moisturizing Hydrocortisone Itch and Bite Relief First Aid Kit Scalpicin Maximum Strength Basic Case Hydrocortisone Anti-Itch CVS Anti-Itch Hydrocortisone Itch and Rash Cream Hydrocortisone Crm 0.5% Meijer Anti Itch Cream Plus Rexall Hydrocortisone Plus Moisturizers FixMySkin Healing Balm Fragrance-Free Regular Strength Hydrocortisone Cream Shopko Hydrocortisone With Aloe Oticin HC Ear Drops Quatriderm Anti-itch Duane Reade hydrocortisone ShopRite Hydrocortisone Dg Health Hydrocortisone Hydrocortisone Ultra Strength KAISER PERMANENTE Hydrocortisone Hemorrodil Unguento Plus Hydrocortisone Cream Lucky SuperSoft MAXIMUM STRENGTH Cortisone 10 Sensitive Skin Creme Cortizone 10 Cooling Cream Anti-Itch Harris Teeter Anti-Itch Shopko Hydrocortisone Intensive Healing Formula Maximum Strength Cortizone 10 Quick Shot 360 Continuous SeaCalm Skin Itch Relief Instant Cooling 1% Hydrocortisone Dr H Stabilizer Dermasorb AF Complete Kit S-Oint HYDROCORTISONE 1% Cortizone 10 Cooling Health Mart Pharmacy Hydrocortisone Maximum Strength with Aloe Cortizone 10 Hydratensive Healing Anti Itch Intensive Healing Anti Itch Xerese Basic Care Hydrocortisone OLP Hydrocortisone 1% Fulton Street Market Anti itch Monistat Soothing Care Itch Relief Care One Hydrocortisone Maximum Strength Hydrocortisone Plus 12 Moisturizers Ana Cool Rapid Soothing Cooling Formula Bencort 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Kirkland Signature Hydrocortisone Plus Maximum Strength Hydrocortisone Intensive Healing Formula Post-Treatment Repair Cream Proctosedyl Ointment H-Releve Anti-Itch Anti-itch Feminine Care Procto-Pak Tecnu Corticool Hydrocortisone Cream 0.5% Proctosedyl Members Mark Hydrocortisone Equate Hydrocortisone Itch Relief Proactiv Solution Anti-Itch Scalp Dr. Throwers Hydrotet DG Health Hydrocortisone Maximum Strength Healing Tree Calming Anti-itch Care One hydrocortisone maximum strength Vanoxide HC Neomycin, Polymyxin B Sulfates and Hydrocortisone Assured Berkley and Jensen Anti Itch Hydrocortisone Maximum Strength with aloe FixMySkin Healing Balm Vanilla Flavor Anti-Itch Scherer Labs Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizers Hydrocortisone maximum strength Rodan and Fields Soothe Corticol-Aloe Proctosedyl Sup Cicatricure Ultra Moisturizing Up and Up Hydrocortisone One Per Cent Cortenema hydrocortisone Iodoquinol Welly Adventure First Aid Kit Sterex Lot Plus Hydrocortisone HC Sarna HC Quality Choice Hydrocortisone Maximum Strength Aquaphor Itch Relief Careone Anti Itch Family Care Hydrocortisone Refuge HC Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2% TopCare Hydrocortisone CeraVe Developed with Dermatologists Anti Itch Post peel Protectant Vitality Institute ProCure Hydrocortisone Cream Plus Medi-First OREAD GOLD Anti-Itch Foam Cortizone 10 Sensitive Skin Anti-itch Creme CVS Cools Itch Fast Triple Antibiotic HC 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Loesch Anti-Itch Therapy Aveeno Hydrocortisone Anti Itch Meijer Max. Strength Anti-Itch Cream Intensive Healing Formula Calmurid HC Crm Discount Drug Mart Anti-itch Welly Itch Fix Proctol Suppositories Hydrocortisone Cream 1% with Aloe Vera Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Hydrocortisone with aloe Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% Hydrocortisone 0.5% / Hydroquinone 6% Cortane-B Publix hydro plus Cortisone Maximum Strength Alacort ProCure Hydrocortisone Plus Calendula Dermazene Home PapKit Meijer Intense Healing Efmody Signature Care Hydrocortisone Apres Peel Soothing Balm Psoriasin Itch Control CVS Anti itch Welly First Aid Kit Rephresh Cooling Viniferamine Hydrocortisone Cream CVS Cortisone Cortaid Intensive Therapy Cooling Equate Hydrocortisone Topical Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension Cortizone-10 Soothing Aloe Creme UEC Medical Anti-Itch Neomycin and Polymyxin B Sulfates and Hydrocortisone meijer Hydrocortisone Cooling Itch Relief Well at Walgreens Equaline Anti Itch Maximum Strength NeilMed Anti-Itch Family Care Anti-Itch Berkley and Jensen Hydrocortisone Family Wellness Maximum Strength Hydrocortisone Itch relief Cream 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Auro-hydrocortisone TrueLipids 1% Hydrocortisone Barrier Cream SKIN A COOL Hydrocortisone Anti-Itch Maximum Strength Cortisone Dermaquest Skin Therapy Post-Skin Resurfacing Balm Good Neighbor Pharmacy Hydrocortisone with Aloe Poison Oak AVON HeXashield Anti Itch Cream with Healing Aloe Hydrocortisone Rectal Suspension (Retention) Medi-First Hydrocortisone SAFEWAY Hydrocortisone Plus 12 Moisturizers CVS Maximum Strength Feminine Anti-Itch Cream Anti-Itch with Aloe Duane Reade hydrocortisone plus 12 moisturizers Harris Teeter Anti-Itch Intensive Healing Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% Anti-Itch Scalp Relief Maximum Strength Exchange Select Hydrocortisone Hydro Skin Hycort Retention Enema 100mg/60ml Poison Oak and Ivy Aloe Cort Maximum Strength Hydrocortisone Cream with Aloe CliniCalm Instant Cooling Itch Relief CVS Meijer Anti-itch with Aloe Sarna Whipped Foam Up and Up Hydrocortisone Makesense Maximum Strength Cortizone 10 Poison Ivy Relief Pads Family Wellness Zims Advanced Hydrocortisone Continuous With Organic Arnica and Aloe Dr. Sheffield Hydrocortisone Anti itch Anti Itch Maximum Strength Plus Proctozone HC Aquacort Lotion 2.5% Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone Up and Up anti itch Smart sense Hydrocortisone Zims Advanced Crack Creme With Hydrocortisone meijer Hydrocortisone Plus 12 Moisturizers Insect Bite Relief Odan Proctomyxin HC Suppositories Leader Hydrocortisone Hydrocortisone Micro Pharmaskincare Acnecare Cream Equate Hydrocortisone Intensive Healing Formula Hydrocortisone Anti Itch Procto-Med HC FixMySkin HEALING LIP BALM unflavoured Cortaine -B Aqueous Publix Hydro Signature Care Anti Itch Shoprite Hydrocortisone DG health hydrocortisone sunmark Hydrocortisone Barmicil Anti-itch Hydrocortisone with Aloe Maximum Strength Meijer Maximum Strength Anti-itch Mycozyl HC Formu Care Anti Itch maximum strength Cortizone 10 Plus Alumier MD Post Procedure Kit with Hydrocortisone Cortizone 10 Ultra Soothing Creme Hydrocortisone Cream 1% Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Plenadren Cooling Itch Relief Rite Aid signature care Hydrocortisone NU-DERM Tolereen Anti-pruritic Anusol HC Intensive Healing Eczema Scarguard MD Hydrocortisone Ointment 1% Instant Cooling Itch Relief Aveeno Hydrocortisone ANTI-ITCH CVS Maximum Strength Anti-Itch Cream First Aid Only Hydrocortisone 1% Anti-Itch Pharmaskincare Brightening Dermarelief Cream Itch Fixer Preparation H Hydrocortisone Cortizone 10 Face Values Hydrocortisone With Aloe Blue-Emu Anti-Itch Cream Schein Hydrocortisone FixMySkin HEALING BODY BALM Fragrance-Free Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% CVS Health Maxium Strentgh Cortisone CeraVe Anti-Itch Cipro HC Yes To Coconut Eczema Relief Colocort Cortibalm Sunmark Hydrocortisone Plus Total Relief Caldecort Quatriderm Creme Nf Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2% H Plus Holdings Nourishing Cho-A Care Lot 1% Ala-Scalp Pharmaskincare Multi-Gly Skin Relief Cream Anti-Itch Regular Strength HEM-EASY RELIEF Herbal Anti-Itch MAXIMUM ITCH RELIEF Cooling Itch Relief Quality Choice Hydrocortisone Scalpicin Anti-Itch Maximum Strength Up and Up Intensive Healing Maximum Strength Anti-Itch Cortisone 10 Intensive Moisture Creme DG Health Hydrocortisone Cortaid Maximum Strength Thera Plus Vioform Hydrocortisone Mild Beard Medicated Cremo Antibiotic Ear (Neo/Polym/HC) Good Sense Anti Itch Maximum Strength Hydrocortisone Cream Healthy Accents Cortisone Maximum Strength Good Neighbor Pharmacy Hydrocortisone With Aloe for Sensitive Skin Western Family HydroCortisone Alcortin Avedana Hydrocortisone Maximum Strength Cortizone 10 Hydratensive Soothing Anti Itch Walgreens Hydrocortisone Plus 12 Moisturizers DermaCort Anti-itch Harris Teeter Maximum Strength Anti-Itch Sterex Crm Plus Cortizone 10 Intensive Healing Hydrocortisone Cream USP 0.5% Hydrocortisone Ointment 0.5% Cortizone 10 Cooling Relief Welly Superhero Supplies Kit Hydrocortisone Cream Intensive Healing Neo-poly-bac Hydro Xpect Hydrocortisone Cortate Ont 1% Up and Up anti itch maximum strength Ala Quin Dermarest Eczema Medicated Proctocort Alumier MD Intensive Recovery CVS Health Hydrocortisone Anti Itch Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizers Hytone Market Basket Anti-Itch Cream Plus Hydrocortisone Maximum Strength with Aloe Kera HC Weeks and Leo Anti-itch Cortizone 10 Easy Relief Aloe Cort Calming Cream Premier Value Hydrocortisone Vioform Hydrocortisone Meijer Maximum Strength Anti-itch Cream Ultra Moisturizing Formula 1oz TopCare Hydrocortisone 1% with Aloe Cortisporin Hydrocortisone 1 S-Cream HYDROCORTISONE 1% Medi-Cortisone with Aloe Cortisporin Ophthalmic FIRST Dukes Mouthwash Compounding Careone Hydrocortisone 1 Maximum Strength Audiologist Anti-itch Meijer Maximum Strength Anti-itch Cream wiith Aloe Neosporin Eczema Essentials Anti Itch OLIVIA QUIDO FIRM and FADE II Leader Hydrocortisone With Aloe Quality Choice Itch Relief Hydrocortisone 1 Plus 10 AFASSCO 1% Hydrocortisone Cortenema Sus 100mg/60ml
Indication	Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.[L16533]
Categories	11-Hydroxycorticosteroids 17-Hydroxycorticosteroids Adrenal Cortex Hormones Adrenals Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Alimentary Tract and Metabolism Anti-Inflammatory Agents Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents Corticosteroid Hormone Receptor Agonists Corticosteroids Corticosteroids Acting Locally Corticosteroids for Local Oral Treatment Corticosteroids for Systemic Use Corticosteroids for Systemic Use, Plain Corticosteroids, Dermatological Preparations Corticosteroids, Weak (Group I) Cytochrome P-450 CYP2A6 Inducers Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C8 Inducers Cytochrome P-450 CYP2C8 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Dermatologicals Fused-Ring Compounds Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hydrocortisone and derivatives Hydroxycorticosteroids Hyperglycemia-Associated Agents Immunosuppressive Agents Intestinal Antiinflammatory Agents Nasal Preparations OAT3/SLC22A8 Substrates Ophthalmological and Otological Preparations Ophthalmologicals Otologicals P-glycoprotein inducers P-glycoprotein substrates Pregnanes Pregnenediones Pregnenes Sensory Organs Steroids Stomatological Preparations Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins Vasoprotectives
ATC-Code	S01CB03 A01AC03 S01BA02 S01CA03 D07AA02 S01BB01 D07XA01 D07BA04 S02CA03 A07EA02 S02BA01 R01AD60 H02AB09 D07CA01 S03CA04 C05AA01
CAS number	50-23-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Glucocorticoid receptor	MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAV...	unknown	agonist
Annexin A1	MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAA...	unknown	agonist
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inducer
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	substrate
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	substrate
Cytochrome P450 11B1, mitochondrial	MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWL...	unknown	substrate
Cytochrome P450 11B2, mitochondrial	MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWL...	unknown	substrate
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inducer
3-oxo-5-beta-steroid 4-dehydrogenase	MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYR...	unknown	substrate
3-oxo-5-alpha-steroid 4-dehydrogenase 2	MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPAR...	unknown	substrate
Corticosteroid 11-beta-dehydrogenase isozyme 2	MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQR...	unknown	substrate
Corticosteroid 11-beta-dehydrogenase isozyme 1	MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREM...	unknown	substrate
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inducer
Cytochrome P450 1B1	MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSA...	unknown	inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inducer
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inducer
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	inducer
Sex hormone-binding globulin	MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNG...	unknown	binder
Corticosteroid-binding globulin	MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSL...	unknown	binder
P-glycoprotein 1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate,inducer
Solute carrier organic anion transporter family member 1A2	MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQ...	unknown	inhibitor
Solute carrier family 22 member 8	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL389621
PubChem	5754
ChEMBL	CHEMBL389621
ChEBI	CHEBI:17650
CCDC/CSD	ZZZPNG01, ZZZPNG03, GOGQEZ, CORTMS01, COWNEI, CORTMS, ZZZPNG02, CORTPY, SACWAY01, SACWAY, ZZZPNG04
COD	1559402