IMP

INOSINIC ACID

Created:	1999-07-08
Last modified:	2024-09-27

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176 entries where IMP is found as a standalone ligand14 entries where IMP is covalently linked to polymer or other heterogen groups 1 entries where IMP is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	36
Chiral Atom Count	4
Bond Count	38
Aromatic Bond Count	5

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Chemical Component Summary
Name	INOSINIC ACID
Systematic Name (OpenEye OEToolkits)	[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
Formula	C₁₀ H₁₃ N₄ O₈ P
Molecular Weight	348.206
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C1c2ncn(c2N=CN1)C3OC(C(O)C3O)COP(=O)(O)O
SMILES	CACTVS	3.385	O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(O)=O)n2cnc3C(=O)NC=Nc23
SMILES	OpenEye OEToolkits	1.7.5	c1nc2c(n1C3C(C(C(O3)COP(=O)(O)O)O)O)N=CNC2=O
Canonical SMILES	CACTVS	3.385	O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(O)=O)n2cnc3C(=O)NC=Nc23
Canonical SMILES	OpenEye OEToolkits	1.7.5	c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)N=CNC2=O
InChI	InChI	1.03	InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKey	InChI	1.03	GRSZFWQUAKGDAV-KQYNXXCUSA-N

Drug Info: DrugBank

DrugBank ID	DB04566
Name	Inosinic Acid
Groups	experimental
Description	Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
Synonyms	Inosinic Acid Cytosine inosinate
Categories	Heterocyclic Compounds, Fused-Ring Inosine Nucleotides Nucleic Acids, Nucleotides, and Nucleosides Nucleotides Purine Nucleotides Purines Ribonucleotides
CAS number	131-99-7

Drug Targets

Name	Target Sequence	Pharmacological Action
Glycogen phosphorylase, muscle form	MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPR...	unknown
Adenylosuccinate synthetase	MGNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEK...	unknown
Inosine-5'-monophosphate dehydrogenase 2	MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVD...	unknown
Adenylosuccinate synthetase isozyme 1	MSGTRASNDRPPGAGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVV...	unknown
Adenylosuccinate synthetase	MGNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEK...	unknown
Inosine-5'-monophosphate dehydrogenase	MSNWDTKFLKKGYTFDDVLLIPAESHVLPNEVDLKTKLADNLTLNIPIIT...	unknown
Hypoxanthine phosphoribosyltransferase	MKHTVEVMIPEAEIKARIAELGRQITERYKDSGSDMVLVGLLRGSFMFMA...	unknown
Hypoxanthine-guanine phosphoribosyltransferase	MPREYEFAEKILFTEEEIRTRIMEVAKRIADDYKGKGLRPYVNPLVLISV...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682