LYS

LYSINE

Created:	1999-07-08
Last modified:	2024-09-27

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187 entries where LYS is found as a standalone ligand67 entries where LYS is covalently linked to polymer or other heterogen groups 227,626 entries where LYS is found in a polymer sequence

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Chemical Details
Formal Charge	1
Atom Count	25
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	0

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Chemical Component Summary
Name	LYSINE
Systematic Name (OpenEye OEToolkits)	[(5S)-5-amino-6-hydroxy-6-oxo-hexyl]azanium
Formula	C₆ H₁₅ N₂ O₂
Molecular Weight	147.195
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CCCC[NH3+]
SMILES	CACTVS	3.341	N[CH](CCCC[NH3+])C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@@H](CCCC[NH3+])C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])C[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKey	InChI	1.03	KDXKERNSBIXSRK-YFKPBYRVSA-O

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00123
Name	Lysine
Groups	nutraceutical approved
Description	Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Synonyms	(S)-α,ε-diaminocaproic acid Lysine monohydrate (S)-2,6-diaminohexanoic acid Lysine acid L-Lysine Lysine acetate Lysine hydrochloride L-Lysin Lysinum Lysine dihydrate LYS (S)-lysine Lysina Lysine L-2,6-Diaminocaproic acid L-lys 6-ammonio-L-norleucine
Brand Names	ProcalAmine 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II Travasol Amino Acid Inj 5.5% Xyzmune Smofkabiven Extra Nitrogen Electrolyte Free Travasol Olimel 3.3% E Aminosyn-PF 10% Aminosyn II 7% M In 10% Dextrose(dual Chamber) Primene Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) HepatAmine 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Olimel 5.7% E 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn II 5% Inj Aminosyn 8.5% Injection With Electrolytes Aminosyn II 10% With Electrolytes Vamin N Clinimix Aminosyn-PF 7% 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Clinisol Olimel 7.6% Lysakare Nutrineal Pd4 Plenamine ProSol 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Premasol - sulfite-free (Amino Acid) Travasol Inj Without Electrolytes 5.5% Renamin (amino Acids) Injection 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Smofkabiven Peripheral 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn 10% W Electrolytes NephrAmine Olimel 4.4% Aminosyn 20% Prosol 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II with Electrolytes Travasol E 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Essepna Smofkabiven Aminosyn Sulfite Free Aminosyn-PF Travasol Amino Acid Inj 8.5% Aminosyn II and Dextrose Primene 10%-liq IV RenAmin 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Smofkabiven Electrolyte Free Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Primene 10% 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Aminosyn II with Electrolytes in Dextrose with Calcium Smofkabiven Extra Nitrogen 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Synthamin Aminosyn 7% Vamin 18 Electrolyte-free Aminosyn 5% 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Olimel 7.6% E Nephramine Liq IV Aminosyn II in Dextrose Aminosyn 3.5% M Perikabiven FreAmine III 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Effervescent Potassium Chloride Aminosyn HF Aminosyn II 8.5% With 50% Dextrose Aminosyn II In Dextrose Injection Travasol Inj Without Electrolytes 8.5% Olimel 4.4% E Novamine TrophAmine Aminosyn II 7% With 50% Dextrose Aminosyn RF Injection Clinimix E 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn II 7% With 10% Dextrose Imubolic 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. 8.5% Freamine III 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Hepatasol Olimel 5.7% Aminosyn II 8.5% Injection Aminosyn 8.5% FreAmine HBC Aminosyn RF Kabiven Periolimel 2.5% E 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Aminosyn II 7% Injection
Indication	Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Categories	Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Detoxifying Agents for Antineoplastic Treatment Dietary Supplements I.V. Solution Additives Lysine Proteinogenic Amino Acids Supplements
ATC-Code	V03AF11 B05XB03
CAS number	56-87-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
High affinity cationic amino acid transporter 1	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 4	MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGM...	unknown
Cationic amino acid transporter 3	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 2	MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGA...	unknown
Lysine--tRNA ligase	MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQ...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682