MGP

7-METHYL-GUANOSINE-5'-TRIPHOSPHATE

Created:	2001-05-16
Last modified:	2011-06-04

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34 entries where MGP is found as a standalone ligand

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Chemical Details
Formal Charge	1
Atom Count	52
Chiral Atom Count	6
Bond Count	54
Aromatic Bond Count	5

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Chemical Component Summary
Name	7-METHYL-GUANOSINE-5'-TRIPHOSPHATE
Systematic Name (OpenEye OEToolkits)	[(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-7-ium-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl (hydroxy-phosphonooxy-phosphoryl) hydrogen phosphate
Formula	C₁₁ H₁₉ N₅ O₁₄ P₃
Molecular Weight	538.215
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2c[n+](c1c2N=C(N)NC1=O)C)C(O)C3O
SMILES	CACTVS	3.341	C[n+]1cn([CH]2O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]2O)c3N=C(N)NC(=O)c13
SMILES	OpenEye OEToolkits	1.5.0	C[n+]1cn(c2c1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
Canonical SMILES	CACTVS	3.341	C[n+]1cn([C@@H]2O[C@H](CO[P@](O)(=O)O[P@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]2O)c3N=C(N)NC(=O)c13
Canonical SMILES	OpenEye OEToolkits	1.5.0	C[n+]1cn(c2c1C(=O)NC(=N2)N)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O)O
InChI	InChI	1.03	InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p+1/t4-,6-,7-,10-/m1/s1
InChIKey	InChI	1.03	DKVRNHPCAOHRSI-KQYNXXCUSA-O

Drug Info: DrugBank

DrugBank ID	DB02716
Name	7-methyl-guanosine-5'-triphosphate
Groups	experimental
Synonyms	7-methyl-guanosine-5'-triphosphate 7-methylguanosine 5'-(tetrahydrogen triphosphate) 7-methyl-GTP(1+)

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Eukaryotic translation initiation factor 4E	MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKN...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682