NVA

NORVALINE

Created:	1999-07-08
Last modified:	2024-09-27

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8 entries where NVA is found as a standalone ligand3 entries where NVA is covalently linked to polymer or other heterogen groups 14 entries where NVA is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	19
Chiral Atom Count	1
Bond Count	18
Aromatic Bond Count	0

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Chemical Component Summary
Name	NORVALINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-aminopentanoic acid
Formula	C₅ H₁₁ N O₂
Molecular Weight	117.146
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CCC
SMILES	CACTVS	3.341	CCC[CH](N)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	CCCC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	CCC[C@H](N)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	CCC[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKey	InChI	1.03	SNDPXSYFESPGGJ-BYPYZUCNSA-N

Drug Info: DrugBank

DrugBank ID	DB04185
Name	Norvaline
Groups	experimental
Description	Norvaline is an isomer of the more common amino acid valine.
Synonyms	2-Aminopentanoic acid L-2-aminopentanoic acid 2-Aminovaleric acid L-Norvaline Norvaline (S)-2-Aminopentanoic acid L-2-Aminovaleric acid
Categories	Amino Acids Amino Acids, Branched-Chain Amino Acids, Peptides, and Proteins
CAS number	6600-40-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Glycine amidinotransferase, mitochondrial	MLRVRCLRGGSRGAEAVHYIGSRLGRTLTGWVQRTFQSTQAATASSRNSC...	unknown
Ornithine carbamoyltransferase, mitochondrial	MLFNLRILLNNAAFRNGHNFMVRNFRCGQPLQNKVQLKGRDLLTLKNFTG...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6950514, 65098
ChEMBL	CHEMBL55612
ChEBI	CHEBI:58441, CHEBI:18314
CCDC/CSD	BERQEU, FITJEX, BERNER, POVYIJ, UHEPOM, ZATMEQ, ZATMAM, ZATNOB, ZATMIU, ZATPOD, ZATPAP, ZATNAN