PAR

PAROMOMYCIN

Created:	2000-08-25
Last modified:	2020-05-27

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100 entries where PAR is found as a standalone ligand6 entries where PAR is covalently linked to polymer or other heterogen groups

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Chemical Details
Formal Charge	0
Atom Count	87
Chiral Atom Count	19
Bond Count	90
Aromatic Bond Count	0

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Chemical Component Summary
Name	PAROMOMYCIN
Synonyms	PAROMOMYCIN I; AMMINOSIDIN; CATENULIN; CRESTOMYCIN; MONOMYCIN A; NEOMYCIN E
Systematic Name (OpenEye OEToolkits)	(2R,3S,4R,5R,6S)-5-amino-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol
Formula	C₂₃ H₄₅ N₅ O₁₄
Molecular Weight	615.628
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O(C2C(OC1OC(CO)C(O)C(O)C1N)C(N)CC(N)C2O)C4OC(C(OC3OC(CN)C(O)C(O)C3N)C4O)CO
SMILES	CACTVS	3.341	NC[CH]1O[CH](O[CH]2[CH](O)[CH](O[CH]2CO)O[CH]3[CH](O)[CH](N)C[CH](N)[CH]3O[CH]4O[CH](CO)[CH](O)[CH](O)[CH]4N)[CH](N)[CH](O)[CH]1O
SMILES	OpenEye OEToolkits	1.5.0	C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
Canonical SMILES	CACTVS	3.341	NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO)O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N)[C@H](N)[C@@H](O)[C@@H]1O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N
InChI	InChI	1.03	InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChIKey	InChI	1.03	UOZODPSAJZTQNH-LSWIJEOBSA-N

Drug Info: DrugBank

DrugBank ID	DB01421
Name	Paromomycin
Groups	approved investigational
Description	An oligosaccharide antibiotic produced by various streptomyces. [PubChem]
Synonyms	Neomycin E Hydroxymycin Paromomycin Paromomycine Monomycin A Aminosidine Catenulin Paromomycin sulfate Paromomicina Crestomycin Paucimycinum Zygomycin A1 (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside Paromomycinum Estomycin Paromomycin I Aminosidin Paucimycin
Brand Names	Paromomycin Sulfate Humatin
Indication	For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.
Categories	Agents that produce neuromuscular block (indirect) Alimentary Tract and Metabolism Amebicides Aminoglycoside Antibacterials Anti-Bacterial Agents Anti-Infective Agents Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents Antiparasitic Agents Antiprotozoals Carbohydrates Glycosides Intestinal Antiinfectives Nephrotoxic agents
ATC-Code	A07AA06
CAS number	7542-37-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
30S ribosomal protein S10	MPKIRIKLRGFDHKTLDASAQKIVEAARRSGAQVSGPIPLPTRVRRFTVI...	unknown	inhibitor
16S ribosomal RNA	-	unknown	inhibitor
40S ribosomal protein SA	MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIIN...	unknown	inhibitor
60S ribosomal protein L10-like	MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGG...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682