PHE

PHENYLALANINE

Find entries where: PHE

is present as a standalone ligand in 107 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 63 entries

is present in a polymer sequence 219,310 entries

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Chemical Component Summary
Name	PHENYLALANINE
Identifiers	(2S)-2-amino-3-phenyl-propanoic acid
Formula	C₉ H₁₁ N O₂
Molecular Weight	165.189
Type	L-PEPTIDE LINKING
Isomeric SMILES	c1ccc(cc1)C[C@@H](C(=O)O)N
InChI	InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
InChIKey	COLNVLDHVKWLRT-QMMMGPOBSA-N

Chemical Details
Formal Charge	0
Atom Count	23
Chiral Atom Count	1
Bond Count	23
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB00120
Name	Phenylalanine
Groups	nutraceutical approved investigational
Description	Phenylalanine is an essential aromatic amino acid that is a precursor of melanin, [dopamine], [noradrenalin] (norepinephrine), and [thyroxine].
Synonyms	(S)-alpha-Amino-beta-phenylpropionic acid Phenylalanine sodium (S)-2-Amino-3-phenylpropionic acid Fenilalanina beta-Phenyl-L-alanine Phenylalanine hydrochloride Phenylalanine β-phenyl-L-alanine Phenylalaninum Phe L-Phenylalanine 3-phenyl-L-alanine F
Brand Names	2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Aminosyn II with Electrolytes 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Kabiven 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Smofkabiven Extra Nitrogen Electrolyte Free 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Clinimix Aminosyn II in Dextrose Olimel 7.6% RenAmin 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Clinisol Novamine 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn 10% W Electrolytes Aminosyn-PF 7% Aminosyn II 8.5% Injection Aminosyn II 7% With 10% Dextrose Travasol Amino Acid Inj 5.5% Aminosyn II Aminosyn 20% Prosol Aminosyn RF Injection Nephramine Liq IV Smofkabiven Extra Nitrogen 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn 5% Olimel 4.4% E TrophAmine 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose NephrAmine Smofkabiven 2.75% Travas. Amino Acid InJ.W.elecw.25%dex 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II In Dextrose Injection Aminosyn II 8.5% With 50% Dextrose Aminosyn 8.5% Injection With Electrolytes Olimel 7.6% E ProcalAmine Aminosyn II 7% With 50% Dextrose Travasol Inj Without Electrolytes 8.5% Premasol - sulfite-free (Amino Acid) 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn 3.5% M Primene 10%-liq IV Aminosyn II and Dextrose 8.5% Freamine III Plenamine 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Vamin N Aminosyn-PF Olimel 5.7% Smofkabiven Peripheral Aminosyn II with Electrolytes in Dextrose with Calcium Travasol Inj Without Electrolytes 5.5% 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Smofkabiven Electrolyte Free Aminosyn II 7% Injection Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Perikabiven Essepna Periolimel 2.5% E Aminosyn II 7% M In 10% Dextrose(dual Chamber) Aminosyn 8.5% Primene 10% Synthamin Travasol Vamin 18 Electrolyte-free 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 4.4% Primene Clinimix E Aminosyn HF Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Aminosyn II 10% With Electrolytes 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn Sulfite Free Renamin (amino Acids) Injection Aminosyn 7% Hepatasol Aminosyn II 5% Inj Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec FreAmine III Travasol E 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn RF Travasol Amino Acid Inj 8.5% HepatAmine Aminosyn-PF 10% Olimel 5.7% E Olimel 3.3% E FreAmine HBC Nutrineal Pd4 ProSol
Indication	L-phenylalanine may be helpful in some with depression. It may also be useful in the treatment of vitiligo. There is some evidence that L-phenylalanine may exacerbate tardive dyskinesia in some schizophrenic patients and in some who have used neuroleptic drugs.
Categories	Amino Acids Amino Acids, Aromatic Amino Acids, Cyclic Amino Acids, Essential Amino Acids, Peptides, and Proteins Dietary Supplements Immunosuppressive Agents Myelosuppressive Agents Proteinogenic Amino Acids Supplements
CAS number	63-91-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Tyrosine aminotransferase	MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAK...	unknown
Large neutral amino acids transporter small subunit 2	MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIV...	unknown
Phenylalanine--tRNA ligase alpha subunit	MADGQVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEV...	unknown
Phenylalanine-4-hydroxylase	MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAK...	unknown
Phenylalanine--tRNA ligase, mitochondrial	MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSV...	unknown
Phenylalanine--tRNA ligase beta subunit	MPTVSVKRDLLFQALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQG...	unknown
Tyrosine 3-monooxygenase	MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTA...	unknown	binder
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6925665, 6140
ChEMBL	CHEMBL301523
ChEBI	CHEBI:17295, CHEBI:58095
CCDC/CSD	EDAXIQ02, EDAXIQ05, EDAXIQ06, QURQUP, EDAXIQ, NONZUL, EDAXIQ03, OJEPEY, BEZPAZ, IREKAR, PAXXUJ, RALRUS, GUQCAY, JOTKIM01, VAGVIJ, REPFUN, HUHSOS, JOTKIM, LAGDIG, CADLOK, FETNEY, CADLOK01, NALYEH, YAMVIS, MIFRIC, JAXZIS, IZAQUV, PHALNC01, EQUYEX
COD	2202945, 2200004, 4517356

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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PHE

PHENYLALANINE

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References