Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
Trinitroglycerol
Glycerol, nitric acid triester
Trinitrine
Nitroglycerol
1,2,3-propanetriyl nitrate
Glyceroli trinitratis
Nitroglycerin
Glycerin trinitrate
Glyceroltrinitrat
Nitroglycerine
Propane-1,2,3-triyl trinitrate
Trinitroglycerin
Glyceryl trinitrate
NG
1,2,3-propanetrioltrinitrate
Glycerol trinitrate
Nitromed
Nitroglicerina
Brand Names
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Mylan-nitro Patch 0.8
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Nitro-Time
Nitroglycerin Slocaps
Nitrostat
Trinipatch 0.6
Apo-nitroglycerin
Nitroglycerin Transdermal System
Nitrong SR Srt 2.6mg
Nitro-time
Nitro-dur 0.4
Nitroglycerin ER
Transderm-nitro 0.4
Nitro-bid
Minitran - Patch Trd 72mg/26.6 Sq Cm
Nitrolingual Spray 0.4mg/eam
Nitronal
Minitran
Gonitro
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Trinipatch 0.4
Nitrogard-SR Tab 1mg
Nitrolingual
Nitroglycerin
Transderm-nitro 0.6
Trinipatch 0.2
Tridil Injection 5mg/ml
Nitroglycerin Transdermal Infusion System
Nitroject Inj 1mg/ml
Transderm-nitro 0.8
Nitro-dur 0.6
Transderm Nitro
Mylan-nitro Sublingual Spray
Deluxe Dental Emergency Kit
Mylan-nitro Patch 0.2
Nitroglycerin in Dextrose
Nitrolingual Pumpspray
Nitroglycerin Injection USP
Mylan-nitro Patch 0.6
Basic Dental Emergency Kit
Nitroglycerin Lingual
Nitroglycerin Transdermal Delivery System
Rectiv
Nitro-dur 0.2
Nitrol
Transderm-nitro 0.2
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
NitroMist
Rho-nitro Pumpspray
Mylan-nitro Patch 0.4
Nitroject
Nitroglycerin SR
Nitro-dur
Nitroglycerin In Dextrose
Nitro-dur 0.8
Nitroglycerin Inj 5mg/ml
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
