U10

UBIQUINONE-10

Created:	1999-07-08
Last modified:	2020-06-05

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202 entries where U10 is found as a standalone ligand5 entries where U10 is covalently linked to polymer or other heterogen groups

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Chemical Details
Formal Charge	0
Atom Count	153
Chiral Atom Count	0
Bond Count	153
Aromatic Bond Count	0

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Chemical Component Summary
Name	UBIQUINONE-10
Synonyms	Coenzyme Q10
Systematic Name (OpenEye OEToolkits)	2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione
Formula	C₅₉ H₉₀ O₄
Molecular Weight	863.343
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C1C(=C(C(=O)C(OC)=C1OC)C)C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)C
SMILES	CACTVS	3.341	COC1=C(OC)C(=O)C(=C(C)C1=O)CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
SMILES	OpenEye OEToolkits	1.5.0	CC1=C(C(=O)C(=C(C1=O)OC)OC)CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
Canonical SMILES	CACTVS	3.341	COC1=C(OC)C(=O)C(=C(C)C1=O)C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C
Canonical SMILES	OpenEye OEToolkits	1.5.0	CC1=C(C(=O)C(=C(C1=O)OC)OC)C\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
InChI	InChI	1.03	InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
InChIKey	InChI	1.03	ACTIUHUUMQJHFO-UPTCCGCDSA-N

Drug Info: DrugBank

DrugBank ID	DB09270
Name	Ubidecarenone
Groups	approved investigational nutraceutical
Description	Ubidecarenone, also called coenzyme Q10, is a 1,4-benzoquinone. From its name (Q10), the Q refers to the constitutive quinone group, and 10 is related to the number of isoprenyl subunits in its tail.[A7874] It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative phosphorylation.[A31413] The ubidecarenone is the coenzyme destined for mitochondrial enzyme complexes involved in oxidative phosphorylation in the production of ATP. It is fundamental for cells that have a high metabolic demand.[L1062] Ubidecarenone is sold as a dietary supplement and is not FDA approved as a drug - it is not meant to treat, cure or prevent any disease. FDA does not approve this dietary supplements before sold nor regulate the manufacturing process.[L1063]
Synonyms	Vitamin Q10 Coenzyme q10, (2z)- Coenzyme Q-10 Ubidecarenone CoQ10 Ubiquinone Coenzyme Q10
Brand Names	Coenzyme Q10 Isotonix Vitamin and Mineral Supplement Formula B Q-gel Coenzyme Q10 Co-enzyme Q-10 Capsules Daily Supplement Packs Co-enzyme Q10 30mg Capsules Coenzyme Q10 Tab 10mg Qmelt Coenzyme Q-10 - 30 mg Coq10 With E400 Iu Coenzyme Q10 60mg Cap Co-Q 10 Capsules 50 mg Medi-10 Co-Q-10 Capsules 30mg Coenzyme Q10 + Cellsparc 360 Folic-K Amladex Omnivex Tru-sorb Coq10 Coenzyme Q10 - 10mg (ubiquinone) Co-q10 30mg L.I.P. Complex tensioSAN Now Coq10 100 mg Coenzyme Q10 Coenzyme Q10 - 30mg (ubiquinone) Co-enzyme Q10 50mg Capsules Coquinone Coenzyme Q-10 Capsules Co-q10 M.R.B. 60mg Co-q10 - Cap 60mg Co-q10 and Vitamin E Vita-Rx Diabetic Vitamin Dayavite Coenzyme Q-10 60 mg Biomed Co Q 10 Coenzyme Q10 30 mg Mebolic PROTECT IRON Liquid Neutral C + Coenzyme Q10 Plus Vitamins & Minerals Coenzyme Q10 Cap 30mg Omniquin Corvite Free Xyzbac G Formula S.E. Coenzyme Q10 (60 Mg) Coenzyme Q10 60mg N.U.T. Complex Coq-10 Formula Statin Support Lexazin Xyzbac Nicadan ZX Q-gel Forte Coenzyme Q10 C.V. Formula Formula Dpr Co-enzyme Q10 60mg Capsules Coenzyme Q10 80mg Co-q10 60 Mg Capsules Super 7 Vitamin and Mineral Supplement Taliment Co-enzyme Q10 100mg Folica-V Co-enzyme Q10 Cap 30mg Co-enzyme-q10 Tab Coq10 B.E.T. Complex Coenzyme Q10 100mg Coen.q10w.vit.c and E Beta-car.se Cu Zn Mn Coenzyme Q10 Ubiquinone 60mg - Cap Zyvit Coenzyme Q10 60mg Capsules Co Q 10 - 50mg Cap N.E.U. Complex Coenzyme Q10 Cap 15mg Genicin Vita-Q Watkins Coq10 Co-q10 (ubiquinone) Acti-ubiquinone 50 Cap 50mg Methazel Co-enzyme Q10 60 mg Mebolex Ubiquinone Capsules 20mg Rocky Mountain Co Q 10 Cap 25mg Nutri-chem Coenzyme Q10 20mg Cell Tech Coenzyme Q10 - Cap 30mg Formula Cp Cap Coenzyme Q-10 Coenzyme Q10 30mg Coenzyme Q10 With Hawthorn Extract and Citrus Bioflavonoids Coenzyme Q10 100 mg Zavitrol Coenzyme Co Q10 Cap 10mg Extra 11 Fibrik Vitamin E and Coq10 PreQue 10 Coenzyme-q10 M.R.B. Nutra-Z CoQ10 200mg IQQU Acne Serum VitaXyme Usana Optimizer Coquinone Coenzyme Q-10 Capsules Folika-V Neutral C + Coenzyme Q10 - Cap Coenzyme Co Q10 Cap 30mg Dyzbac Coenzyme Q10 - Capsule 30 mg Protect Cardio AF Oveeza Co-q10 M.R.B. 100mg and Vitamin E Coenzyme Q10 50 mg Thera Q Plus Co-q10 Cap 30mg Co-enzyme Q-10 Co-q10 30mg (ubiquinone) Folica BE Biogard Ubiquinone Cap 30mg Biosculpt Coenzyme Q10 50mg Formula O.C. Q-10 Plus Protect Plus SO 60 Vitazyme Q-10 Extra -cap
Indication	The diet supplements containing ubidecarenone are indicated, as stated in the product label, to assist individuals with cardiovascular complaints including congestive heart failure and systolic hypertension. In the product, ubidecarenone is used to increase the cardiac input as well as for the prevention of several other diseases like Parkinson, fibromyalgia, migraine, periodontal disease and diabetes, based on preclinical studies.[L1064] It is important to highlight that these products are not FDA approved and it is recommended to use under discretion.
Categories	Agents Causing Muscle Toxicity Benzoquinones Cardiac Therapy Coenzymes Diet, Food, and Nutrition Electron Transport Chain Complex Proteins Enzymes and Coenzymes Food Hypoglycemia-Associated Agents Micronutrients Other Nutritional Agents P-glycoprotein substrates Physiological Phenomena Quinones Ubiquinone Vitamins
ATC-Code	C01EB09
CAS number	303-98-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSK...	unknown	cofactor
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDS...	unknown	cofactor
3-hydroxy-3-methylglutaryl-coenzyme A reductase	MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYEC...	unknown	substrate
Low-density lipoprotein receptor	MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSA...	unknown	substrate
Very low-density lipoprotein receptor	MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLW...	unknown	substrate
P-glycoprotein 1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682